Platelet‑rich plasma as a method of treatment of androgenetic alopecia in men — a case report

2020 ◽  
Vol 3 (1) ◽  
pp. 27-33
Author(s):  
Patrycja Przybylska ◽  
Teresa Matthews‑Brzozowska
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Nutritional Supplementation ◽  
Androgenetic Alopecia ◽  
Common Condition ◽  
Minimal Invasiveness ◽  
Photographic Documentation ◽  
Hair Transplant

Androgenetic alopecia is a common condition, accounting for about 95% of all male hair loss. Standard therapeutic solutions recommend the use of minoxidil, finasteride, spironolactone, nutritional supplementation, phototherapy and hair transplant surgery. An increasingly popular alternative method that has been used in the case report is platelet rich plasma (PRP) mesotherapy characterized by autologous character, minimal invasiveness and no serious side effects. A series of 3 treatments was performed at 3-week intervals. The effects of using medical photographic documentation after completing a series of treatments.

scholarly journals Skin care physicians insight on epidemiological patterns, diagnosis and treatment modalities for female pattern hair loss

2020 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Krishna Rajesh Kilaru ◽  
Suhasini Attada ◽  
Pooja Munnangi ◽  
Manogna Chowdary Kilaru
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Treatment Guidelines ◽  
Age Of Onset ◽  
Platelet Rich Plasma ◽  
Diagnosis And Treatment ◽  
Treatment Modalities ◽  
Common Side Effect ◽  
Medication Cost ◽  
Female Pattern Hair Loss

<p class="abstract"><strong>Background:</strong> Female pattern hair loss (FPHL) is a common cause of hair loss in women characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. The underlying pathophysiology is multifactorial. There are no universally agreed treatment guidelines available. The objective of the study was to understand the diagnosis and treatment pattern of female pattern hair loss and the role of minoxidil topical formulation and its combination in the management of FPHL.</p><p class="abstract"><strong>Methods: </strong>Predesigned questionnaire on FPHL was prepared based on review of literature and was filled by 80 consultant dermatologists. Recorded data was statistically analyzed.</p><p class="abstract"><strong>Results: </strong>Common age of onset of FPHL was between 20 to 30 years. Majority (96.25%) have reported FPHL in association with psychological morbidity. The most preferred treatment in mild and severe FPHL was minoxidil 5% and platelet rich plasma (PRP) plus minoxidil respectively. Most dermatologists (47.5%) treated with minoxidil for over 6 months. Majority (27.5%) reported flaking as the most common side effect with minoxidil followed by dryness, scalp irritation and itching. Majority (27.5%) observed that long treatment duration was contributing to non-compliance followed by medication cost and side effects. Majority of the dermatologists (90%) felt the need for treatment guidelines in the current Indian scenario.</p><p class="abstract"><strong>Conclusions: </strong>Minoxidil was the most common preferred treatment for mild and severe FPHL. PRP is the most common choice of combination therapy with minoxidil. Minimizing side effects, patient education and universal treatment guidelines can help manage FPHL better.  </p>

scholarly journals Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 311
Author(s):  
Santo Raffaele Mercuri ◽  
Giovanni Paolino ◽  
Matteo Riccardo Di Nicola ◽  
Laura Vollono
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Cochrane Central Register ◽  
Review Of The Literature ◽  
Psychosocial Burden ◽  
Female Pattern Hair Loss ◽  
Central Register ◽  
Topical Minoxidil

Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments.

Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahira Hamdy El Sayed ◽  
Marwa Yassin Soltan ◽  
Ahmed Sadek ◽  
Mohamed Abo Shabana Hussein Mohamed
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Early Onset ◽  
University Hospital ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
Terminal Hair ◽  
Reactive Oxygen Species Scavenger ◽  
Male Pattern

Abstract Background Androgenetic alopecia (AGA), the most common form of hair loss in men, involves the progressive loss of visible pigmented terminal hair on the scalp in response to circulating androgens. AGA is an autosomal disorder which begins in puberty in genetically predisposed individuals. Aim of the Work To study the effectiveness and safety of the reactive oxygen species scavenger Nacetyl-cysteine (NAC) as a single therapy and in combination with the topically applied minoxidil for treatment of the early-onset androgenetic alopecia in men. Patients and Methods The present study included 100 patients with male pattern hair loss whose age ranged from 18 to 30 years old, recruited from dermatology clinics in Ain Shams University Hospital and Kafr El Sheik University Hospital. Results Overall, all treatments could improve significantly some of the trichoscopic parameters as compared to the control group who did not receive any treatment. The number of terminal hair count increased and the vellus hair count decreased in response to either of treatments; minoxidil, NAC, or both as compared to control. These changes were noticed at both the vertex and frontotemporal sites. The treatment was generally tolerable and the side effects encountered did not necessitate stoppage of the treatment course. Conclusion On the basis of the findings of current study we can conclude that, the role of trichoscopy in increasing the accuracy for diagnosing hair disorders as well as to detect response or failure to treatment, N-acetylcysteine (NAC) improved significantly most of the trichoscopic features of AGA and it was was generally tolerable and the side effects encountered did not necessitate stoppage of the treatment course.

scholarly journals Evaluation of using stromal vascular fraction and platelet rich plasma in the treatment of androgenetic alopecia

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A B Osama ◽  
Elfeky K Ahdallah ◽  
E K M Ali ◽  
N A Mamdouh
Keyword(s):  
Side Effects ◽  
Clinical Improvement ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Androgenetic Alopecia ◽  
Serious Adverse Events ◽  
Terminal Hair ◽  
Significant Difference ◽  
Potential Therapeutic Application ◽  
Fraction Versus

Abstract Background Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment through injection of stromal vascular fraction were recently introduced as an alternative potential therapeutic application for hair growth. Purpose This study aims to compare the efficacy, safety and adverse effects of using lipo-aspirate stromal vascular fraction versus Platelet Rich Plasma injection in the treatment of Androgenetic Alopecia (AGA). Patients And Methods Forty randomized patients were treated by PRP, and SVF. Each patient was evaluated. And each lesion was treated by those modalities, patients received three sessions with one month interval for 3 months, follow up after 3 months. Results A highly significant improvement &lt;0.001 in terminal hair count of SVF group evaluated by videodermoscopy assessment of AGA. That were confirmed by highly significant improvement in inter-mediate hair count and mean caliber (&lt;0.001) associated with high incidence of side effects especially headache and erythema. In contrast. PRP group showed significant improvement 0.048 in terminal hair count and non-significant improvement in inter-mediate hair count and of mean caliber with minimum side effects. SVF group showed a significant improvement in terminal hair count than PRP and a highly significant improvement in Inter-mediate hair count. Regard the clinical improvement and photographic assessment, SVF evoked upper hand of clinical improvement than PRP without statistically difference. Also, side effects of SVF showed highly significant pain, headache and erythema but no serious adverse events. Our study suggests that was significant improvement in AGA after PRP and highly significant after SVF therapy, with significant difference of SVF in terminal hair count and highly significant in vellus hair. Both modalities could effectively and safely he used to treat AGA. Conclusion our study suggested that there was significant improvement in AGA after both PRP and highly significant after SVF therapy. The results indicated a significant difference between PRP and SVF regarding terminal hair count and highly significant for vellus hair count, but non-significant difference in hair diameter. Both modalities could effectively and safely be used to treat AGA and there was statistically improvement in AGA after both PRP and SVF therapies.

scholarly journals Androgenetic alopecia in women. Trichoscopy as a diagnostic method to simplify the proper diagnosis — case report

2019 ◽  
Vol 2 (2) ◽  
pp. 111-117
Author(s):  
Dominik Mikiel
Keyword(s):  
Case Report ◽  
Hair Loss ◽  
Laboratory Tests ◽  
Diagnostic Method ◽  
Androgenetic Alopecia ◽  
Diagnostic Process ◽  
Frequent Type ◽  
Proper Diagnosis ◽  
The Right ◽  
Scalp Biopsy

Hair loss is a common problem seen in dermatology. Both women and men are affected. Androgenetic alopecia is one of the most frequent type of hair loss observed in women. The diagnostic process is complex and includes different noninvasive procedures, laboratory tests and sometimes requires scalp biopsy. Trichoscopy is fairly new and useful diagnostic method that enables making the right diagnosis. Treatment of hair loss is often complicated and long‑lasting but in some cases it may be helpful to follow recommendations of various scientific boards. Here, we present a case of a woman with diffuse hair loss whose trichoscopic examination allowed to diagnose androgenetic alopecia.

scholarly journals A six-year old girl presenting with alopecia areata incognita: a case report

2017 ◽  
Vol 3 (1) ◽  
pp. 158
Author(s):  
Ashish Dalal ◽  
Ajay Kumar ◽  
Ritambhara Lohan ◽  
Muskaan Ahlawat
Keyword(s):  
Case Report ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Androgenetic Alopecia ◽  
Sudden Increase ◽  
Middle Aged ◽  
Pull Test

<p class="abstract">A proportion of cases of diffuse hair loss over the scalp mimicking telogen effluvium or androgenetic alopecia are found to have alopecia areata incognita (AAI) on dermascopic examination and histopathology. AAI has commonly been reported in middle aged women who present with a sudden increase in hair shedding with diffuse alopecia developing after several months. Though the typical glabrous patches of hair loss observed in classical alopecia areata are absent, the abrupt and intense hair loss with a positive hair pull test is suggestive of AAI. There are few reports of AAI occurring in children. We are reporting a case of AAI in a 6-year old child. </p>

The Therapeutic Response of Platelet Rich Plasma (PRP) for Androgenetic Alopecia Showed No Correlation with Growth Factors and Platelet Number

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2637-2637 ◽  
Author(s):  
Bruno Lima Rodrigues ◽  
Silmara Aparecida De Lima Montalvão ◽  
Joyce Annichinno-Bizzacchi ◽  
Rebeca Cancela ◽  
Francesca Silva ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Hair Loss ◽  
Hair Growth ◽  
Therapeutic Response ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Autologous Serum ◽  
Platelet Number ◽  
The Mean

Abstract Background: Androgenetic alopecia (AGA) is characterized by a pattern hair loss. Currently, treatment with platelet-rich plasma (PRP) has shown promising results due to the growth factors (GFs) released by the platelets. However, the analysis of therapeutic response according to GFs levels and platelet number in PRP has not been established. Objective: Investigate the therapeutic response to treatment of AGA using a standard method of PRP preparation, and the relation with GFs levels and platelet number. Methods: Inclusion criteria comprised diagnosis of AGA-III-vertex profile according to the Norwood-Hamilton scale, age between 18 and 50 years. Exclusion criteria comprised female gender, previous hair transplantation, any disease related to hair loss such as thyroid disease and/or iron deficiency, neoplasia present or past, kidney, liver, infectious, hematologic or rheumatoid disease, use of antiplatelet and/or anti-inflammatory drugs. All patients provided written informed consent approved by the ethic committee from the Faculty of Medical Sciences of the State University of Campinas (UNICAMP). The protocol comprised 20 subcutaneous injections of 100 µL in the scalp totaling 4 applications every fifteen days, with evaluation performed pretreatment (t0), 45 (t1) and 150 (t2) days after the start of the protocol. The endpoints for therapeutic response were hair growth and increase of percentage of anagen hairs evaluated by TrichoScan. For each patient 40 mL of peripheral blood were collected in ACD tubes. L-PRP (PRP with leukocytes) was performed, with double centrifugation (300 g for 5 minutes, and 700 g for 17 minutes). The platelets were counted in the baseline and in the PRP samples. PRP was activated with autologous serum. The platelet-derived growth factors (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) were measured by Luminex technique (Millipore®, USA), in two different PRP samples from each patient. Results: During the period of August to December of 2014, 15 male patients were included in the study. The median of platelets in PRP was increased by 5 folds in all four PRP preparations with a minimum of 728.9 and maximum 1.901,90 x 106 cel/uL, and median values of 1.082 x 106 cel/uL (range 608 - 2.023). The baseline number of platelets and PRP preparation showed a significant correlation (r = 0.839, p < 0.0001). The variability of platelet numbers from each individual during the four applications was 19.7% with a minimum of 0.50% and a maximum 56.3%. GF quantification of two different PRP preparations showed a similar intra-individual variation, with a mean of variability coefficient of 18.4% for VEGF, 20.9% for PDGF, and 21.6% for EGF (Table 1). EGF and PDGF concentrations showed a significant correlation to PRP platelets number (r = 0.8287 and P < 0.0001, and r = 0.6925 and P=0.0014, respectively) (Figure 1). Our results showed a significant increase in hair count (P = 0.0018) and anagen hairs (P = 0.0070) in 86.6% and 53.3% of patients, respectively. However, no correlation was found between platelet counts and GFs levels with therapeutic response. The patients who presented high levels of GFs did not show better results for hair growth or anagen hair than who presented lower levels. Conclusion: Our results corroborate previous studies that showed PRP as a quite promising therapeutic option for AGA, up to 3 months after the injections. However, there was a lack of correlation between the therapeutic responses and platelet numbers or GFs levels. Although, the GFs were not considered biomarker for PRP, it may play an important role in the PRP therapeutic effect. In addition, our results suggest that the PRP effects depend on an orchestration between many mechanisms involved in the increase of number of hairs and its growth. Furthermore, local receptors might present a central role in this response. Graphs of correlation between the platelet mean in PRP and the mean of the growth factor concentrations Graphs of correlation between the platelet mean in PRP and the mean of the growth factor concentrations Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Platelet-Rich Plasma (PRP) Effect on Androgenetic Alopecia and Female Pattern Hair Loss

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Elham Behrangi ◽  
Abbas Zamanian ◽  
Gholamhossein Ghaffarpour ◽  
Maryam Hashemi Orimi ◽  
Amir Heydarian ◽  
...  
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Female Pattern Hair Loss

Doxycycline-Induced Cutaneous Inflammation with Systemic Symptoms in a Patient with Acne Vulgaris

2013 ◽  
Vol 17 (4) ◽  
pp. 283-286 ◽  
Author(s):  
Miriam Weinstein ◽  
Ronald Laxer ◽  
Joanna Debosz ◽  
Gino Somers
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Acne Vulgaris ◽  
Side Effect Profile ◽  
Common Condition ◽  
Cutaneous Inflammation ◽  
Mood Changes ◽  
The Face ◽  
Systemic Symptoms ◽  
Hands And Feet

Background: Doxycycline is a commonly prescribed antibiotic for the treatment of acne vulgaris. Often preferred to other tetracyclines due to a safer and milder side-effect profile, doxycycline is more frequently prescribed as a treatment of this common condition. Objective: To present a case report of a young patient who developed skin eruptions over the extremities; myalgias; fatigue; swelling involving the face, hands, and feet; headache; and mood changes after 2 years of using doxycycline. She promptly developed similar symptoms after a rechallenge with doxycycline 1 year later. Results/Conclusion: This important finding will make practitioners more vigilant to the side effects of this medication despite its current safety profile and regardless of the time that a patient is using it.

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