Beneficial effects of melatonin and alpha lipoic acid on lopinavir/ritonavir-induced alterations in lipid and glucose levels in male albino rats

2016 ◽  
Vol 85 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Elias Adikwu
Keyword(s):  
Lipoic Acid ◽  
Albino Rats ◽  
Alpha Lipoic Acid ◽  
Beneficial Effects ◽  
Glucose Levels

scholarly journals Melatonin and alpha lipoic acid attenuate methotrexate/ cisplatin-induced kidney toxicity in albino rats

2019 ◽  
Vol 9 (2) ◽  
pp. e17-e17
Author(s):  
Elias Adikwu ◽  
Nelson Clement Ebinyo ◽  
Bonsome Bokolo
Keyword(s):  
Anticancer Drug ◽  
Lipoic Acid ◽  
Malignant Tumors ◽  
Genetic Alterations ◽  
Albino Rats ◽  
Protective Effects ◽  
Alpha Lipoic Acid ◽  
Serum Samples ◽  
Kidney Toxicity ◽  
Beneficial Effects

Introduction: Most anticancer therapies are seldom effective by single anticancer drug due to biologic heterogeneity and multiple genetic alterations stimulating the use of anticancer drug combinations. Methotrexate/cisplatin (MTX/CPT) has shown beneficial effects in the treatment of metastatic and malignant tumors, but its use may perturb kidney function. Objectives: The present study assessed the protective effects of melatonin (MT) and alpha-lipoic acid (ALA) against kidney toxicity induced by MTX/CPT in albino rats. Materials and Methods: Forty-eight adult male albino rats were randomized into groups and pretreated with MT (10 mg/kg), ALA (10 mg/kg) and MT+ALA daily for five days before treatment with 20 mg/kg of MTX and 5 mg/kg of CPT intraperitoneally on the fifth day. After overnight fast, rats were sacrificed, serum samples were centrifuged from blood samples and assessed for renal function parameters and electrolytes. Kidneys were assessed for oxidative stress (OS) markers and pathology. Results: Significant (P<0.001) increases in serum creatinine, urea, and uric acid levels with significant (P<0.001) decreases in total protein, albumin, potassium, sodium, chloride, and bicarbonate levels were obtained in MTX/CPT-intoxicated rats when compared to control. Furthermore, kidney malondialdehyde levels were significantly (P<0.001) increased whereas catalase, superoxide dismutase, glutathione and glutathione peroxidase levels were significantly (P<0.001) decreased in MTX/CPT-intoxicated rats when compared to control. Pathologic changes marked by atrophic glomeruli were detected in the kidneys of MTX/CPT-treated rats. However, nephrotoxicity observed in MTX/CPT-treated rats was significantly reversed in MT (P<0.01), ALA (P<0.05) and MT+ALA (P<0.001) pretreated rats when compared to MTX/CPT -treated rats. Conclusion: MT and ALA supplementations attenuate nephrotoxicity caused by MTX/CPT.

Triple Blood Balance Reviews-[ 100% Netural ] - Amazing Blood Sugar Formula! v1

2021 ◽  
Author(s):  
triplebloodbalance not provided
Keyword(s):  
Cancer Prevention ◽  
Lipoic Acid ◽  
The Body ◽  
Blood Cholesterol ◽  
Medical Services ◽  
Gymnema Sylvestre ◽  
Alpha Lipoic Acid ◽  
Glucose Levels ◽  
White Mulberry ◽  
General Wellbeing

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This can be advantageous in directing your circulatory strain and keeping your heart sound. It even keeps your blood cholesterol kept up with and forestalls cardiovascular issues. This may likewise permit you to have more prominent energy holds and keep you lively. It works with the progression of blood to the mind and the body and advances in general wellbeing. It can reinforce your resistant framework and make you more grounded from within. Normal Ingredients Incorporated to Make Triple Blood Balance Triple Blood Balance is an altogether natural enhancement that just includes the utilization of normal fixings. Here is a finished rundown of the normal fixings fused to make this enhancement A few Vitamins and Minerals: This enhancement includes a mix of supplements like Vitamin C, Vitamin E, Biotin, Magnesium, Manganese, Chromium, and Zinc too. L-Taurine: It is an astounding amino corrosive that aides in dealing with your glucose levels normally. 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scholarly journals Melatonin and alpha lipoic acid attenuate lopinavir/ritonavir - induced testicular toxicity in albino rats

2016 ◽  
Vol 62 (2) ◽  
pp. 17-24
Author(s):  
Elias Adikwu ◽  
Brambaifa Nelson ◽  
Wolfe Atuboyedia Obianime
Keyword(s):  
Lipoic Acid ◽  
Serum Testosterone ◽  
Sperm Parameters ◽  
Oral Exposure ◽  
Albino Rats ◽  
Sperm Cells ◽  
Testicular Toxicity ◽  
Alpha Lipoic Acid ◽  
Testosterone Levels ◽  
Oral Doses

The use of lopinavir/ritonavir (LPV/r) could be associated with testicular toxicity as a limiting factor. The present study evaluated the effects of melatonin (MT) and alpha lipoic (ALA) acid on LPV/r–induced testicular toxicity in male albino rats. Eighty five male albino rats used for this study were randomized into 6 groups (A-F). Rats in groups A1 and A2 served as placebo and solvent control and were orally exposed to water and 1% ethanol, respectively. Rats in group B were exposed to oral doses of MT (10 mg kg-1/day), ALA (10 mg kg-1/day) and combined doses of MT and ALA, respectively. Rats in group C were exposed to oral doses of LPV/r (22.9/5.71 - 91.4/22.9 mg kg-1/ day), respectively. Rats in group D-F were exposed to oral doses of MT (10 mg kg-1/day), ALA (10 mg kg-1/day) and combined doses of MT and ALA prior to oral exposure to LPV/r (22.9/5.71 - 91.4/22.9 mg kg-1/day), respectively. At the end of 60 days of exposure to drugs, rats were sacrificed; blood was collected and serum extracted and evaluated for testosterone. Testes were collected and evaluated for sperm parameters. LPV/r-treated rats showed significant (P<0.05) and dose-dependent decreases in sperm count, sperm motility, sperm viability and serum testosterone levels with increases in abnormal sperm cells, debris, and primordial sperm cells when compared to placebo control. However, LPV/r-induced changes in sperm parameters and serum testosterone levels were attenuated in rats pretreated with MT and ALA. The best effects were observed in rats pretreated with combined doses of MT and ALA. Melatonin and alpha lipoic acid have potential to reduce testicular toxicity associated with lopinavir/ritonavir treatment.

scholarly journals The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Liu ◽  
Lian-jie Shi ◽  
Sheng-guang Li
Keyword(s):  
Autoimmune Diseases ◽  
Lipoic Acid ◽  
Human Body ◽  
Innate Immune ◽  
Immunomodulatory Effect ◽  
Alpha Lipoic Acid ◽  
Immunomodulatory Effects ◽  
Immune Systems ◽  
Beneficial Effects ◽  
Naturally Occurring

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

scholarly journals Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes

2015 ◽  
Vol 93 (12) ◽  
pp. 1021-1027 ◽  
Author(s):  
Luc Rochette ◽  
Steliana Ghibu ◽  
Adriana Muresan ◽  
Catherine Vergely
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Vascular Diseases ◽  
Alpha Lipoic Acid ◽  
Insulin Mimetic ◽  
Beneficial Effects ◽  
Intracellular Compartments ◽  
Endothelial Nitric Oxide

Diabetes is a chronic metabolic disease with a high prevalence worldwide. Diabetes and insulin resistance are associated with the development of cardiovascular and nervous diseases. The development of these disorders reflects complex pathological processes in which the oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) plays a pivotal role. It is widely accepted that diabetes impairs endothelial nitric oxide synthase (eNOS) activity and increases the production of ROS, thus resulting in diminished NO bioavailability and increased oxidative stress. Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and in the treatment of diabetes. LA is a potent antioxidant with insulin-mimetic and anti-inflammatory activity. LA in the diet is quickly absorbed, transported to the intracellular compartments, and reduced to dihydrolipoic acid (DHLA) under the action of enzymes. LA, which plays an essential role in mitochondrial bioenergetic reactions, has drawn considerable attention as an antioxidant for use in managing diabetic complications such as retinopathy, neuropathy and other vascular diseases.

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