scholarly journals High prevalence of non-alcoholic fatty liver disease in patients with inflammatory bowel disease receiving anti-tumor necrosis factor therapy

2019 ◽  
Author(s):  
Alisa Likhitsup
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Tumor Necrosis ◽  
Alcoholic Fatty Liver ◽  
High Prevalence ◽  
Factor Therapy ◽  
Inflammatory Bowel ◽  
Alcoholic Fatty Liver Disease ◽  
Necrosis Factor

scholarly journals Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Juliana Silva ◽  
Beatriz S. Brito ◽  
Isaac Neri de N. Silva ◽  
Viviane G. Nóbrega ◽  
Maria Carolina S. M. da Silva ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Hepatitis B ◽  
Alcoholic Liver Disease ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Reference Center ◽  
Inflammatory Bowel ◽  
Alcoholic Fatty Liver Disease

Background. In inflammatory bowel disease (IBD) patients there are reports of the occurrence of hepatobiliary manifestations, so the aim of this study was to evaluate the hepatobiliary manifestations in patients with Crohn’s disease (CD) and ulcerative colitis (UC) from an IBD reference center. Methods. Cross-sectional study in an IBD reference center, with interviews and review of medical charts, between July 2015 and August 2016. A questionnaire addressing epidemiological and clinical characteristics was used. Results. We interviewed 306 patients, and the majority had UC (53.9%) and were female (61.8%). Hepatobiliary manifestations were observed in 60 (19.6%) patients with IBD. In the greater part of the patients (56.7%) hepatobiliary disorders were detected after the diagnosis of IBD. In UC (18.2%) patients, the hepatobiliary disorders identified were 11 (6.7%) non-alcoholic fatty liver disease, 9 (5.5%) cholelithiasis, 6 (3.6%) primary sclerosing cholangitis (PSC), 3 (1.8%) hepatotoxicity associated with azathioprine, 1 (0.6%) hepatitis B, and 1 (0.6%) hepatic fibrosis. In CD (21.3%) patients, 11 (7.8%) had cholelithiasis, 11 (7.8%) non-alcoholic fatty liver disease, 4 (2.8%) PSC, 3 (2.1%) hepatotoxicity, 1 (0.7%) hepatitis B, (0.7%) hepatitis C, 1 (0.7%) alcoholic liver disease, and 1 (0.7%) autoimmune hepatitis (AIH). There was one case of PSC/AIH overlap syndrome. Conclusion. The frequency of hepatobiliary disorders was similar in both forms of IBD in patients evaluated. The most common nonspecific hepatobiliary manifestations in IBD patients were non-alcoholic liver disease and cholelithiasis. The most common specific hepatobiliary disorder was PSC in patients with extensive UC or ileocolonic CD involvement; this was seen more frequently in male patients.

scholarly journals P786 Non-alcoholic fatty liver disease among patients with inflammatory bowel disease in Qatar: Prevalence and risk factors

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S621-S621
Author(s):  
M Almohannadi ◽  
P Chandra ◽  
B Varughese ◽  
A Darweesh ◽  
A Hamid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Increased Risk ◽  
Inflammatory Bowel ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) has been progressively identified in patients with inflammatory bowel disease (IBD) in Qatar. We aim to characterise NAFLD in IBD patients in Qatar and to determine predictors for its severity. Methods A retrospective observational study was conducted on 913 IBD patients in Hamad hospital between January 2008 and December 2017. The prevalence of NAFLD among IBD cases was estimated and associations between two or more qualitative variables were assessed using χ2-test. Quantitative data between two independent groups were analysed using unpaired t-test. Univariate and multivariate logistic regression analysis were applied to determine the predictive values of each predictor for NAFLD among IBD patients. Results Among 913 IBD patients with a mean age of 36.9 ± 13.2 years and BMI 26.9 ± 6.1; 550 were males (60.2%), 383(41.9%) with Crohn’s disease and 530 (58.1%) with Ulcerative colitis. 24 (22.2%) patients had severe steatosis. The overall prevalence of NAFLD was 11.8% (95% CI 9.9, 14.1) and does not differ significantly between CD and UC patients (11.7% vs. 11.9%; p = 0.949). Patients who developed NAFLD were older at baseline, higher BMI and had a higher prevalence of diabetes and hypertension. Age >50 years (OR 3.34; 95% CI 1.82, 6.14; p = 0.001), BMI >30kg/m2 (OR 2.87; 95% CI 1.71, 4.84; p = 0.001), the presence of hypertension (OR 1.98; 95% CI 1.16, 3.38; p = 0.01) and diabetes mellitus (OR 3.05; 95% CI 1.87, 4.95; p = 0.001), were all positive and significantly associated with an increased risk whereas gender female associated with significantly decreased risk for NAFLD (OR 0.63; 95% CI 0.41, 0.98; p = 0.04). Multivariate analysis showed age >40 to 50 years (adjusted OR 2.98; 95% CI 1.62, 5.48; p = 0.001), age >50 years (adjusted OR 2.03; 95% CI 1.03, 4.0; p = 0.04), BMI>30 kg/m2 (adjusted OR 2.24; 95% CI 1.28, 3.91; p = 0.01) and diabetes mellitus (adjusted OR 1.98; 95% CI 1.15, 3.4; p = 0.02) significantly associated with an increased risk of NAFLD whereas gender female showed protective effect and have decreased risk (adjusted OR 0.58; 95% CI 0.36, 0.93; p=0.02). The treatment with biologic does not increase the risk of steatosis and the predicted cut-off NAFLD score of ≥ -1.67 had good predictive ability for significant steatosis. Conclusion The prevalence of NAFLD in IBD patients was 11.8% in Qatar. We did not find an association between the medications used and the progression to NAFLD in IBD patients. Older age, high BMI and diabetes mellitus increase its risk. Non-invasive screening using NAFLD Score could help early diagnosis and initiation of interventions in such patients.

Risk Factors of Non-alcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease

2012 ◽  
Vol 107 ◽  
pp. S155
Author(s):  
Achuthan Sourianarayanane ◽  
Gaurav Garg ◽  
Thomas Smith ◽  
Mujtaba Butt ◽  
Arthur McCullough ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Inflammatory Bowel ◽  
Alcoholic Fatty Liver Disease

scholarly journals Co-existence of non-alcoholic fatty liver disease and inflammatory bowel disease: A review article

2016 ◽  
Vol 22 (34) ◽  
pp. 7727 ◽  
Author(s):  
Che-Yung Chao ◽  
Robert Battat ◽  
Alex Al Khoury ◽  
Sophie Restellini ◽  
Giada Sebastiani ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Review Article ◽  
Alcoholic Fatty Liver ◽  
Inflammatory Bowel ◽  
Alcoholic Fatty Liver Disease
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