scholarly journals Sterol biosynthesis: 2,3-oxidosqualene analogues

2021 ◽  
Author(s):  
Hisashi Yamamoto
Keyword(s):  
Sterol Biosynthesis

scholarly journals Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

1979 ◽  
Vol 20 (8) ◽  
pp. 994-998
Author(s):  
G J Schroepfer ◽  
E J Parish ◽  
M Tsuda ◽  
D L Raulston ◽  
A A Kandutsch
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

scholarly journals Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.

1980 ◽  
Vol 21 (5) ◽  
pp. 571-584
Author(s):  
G J Schroepfer ◽  
E J Parish ◽  
R A Pascal ◽  
A A Kandutsch
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

scholarly journals Membrane Sterol Composition in Arabidopsis thaliana Affects Root Elongation via Auxin Biosynthesis

2021 ◽  
Vol 22 (1) ◽  
pp. 437
Author(s):  
Meng Wang ◽  
Panpan Li ◽  
Yao Ma ◽  
Xiang Nie ◽  
Markus Grebe ◽  
...  
Keyword(s):  
Root Elongation ◽  
Auxin Transport ◽  
Sterol Composition ◽  
Polar Auxin Transport ◽  
Sterol Biosynthesis ◽  
Auxin Biosynthesis ◽  
Root Tip ◽  
Auxin Signaling ◽  
Auxin Response ◽  
Short Root

Plant membrane sterol composition has been reported to affect growth and gravitropism via polar auxin transport and auxin signaling. However, as to whether sterols influence auxin biosynthesis has received little attention. Here, by using the sterol biosynthesis mutant cyclopropylsterol isomerase1-1 (cpi1-1) and sterol application, we reveal that cycloeucalenol, a CPI1 substrate, and sitosterol, an end-product of sterol biosynthesis, antagonistically affect auxin biosynthesis. The short root phenotype of cpi1-1 was associated with a markedly enhanced auxin response in the root tip. Both were neither suppressed by mutations in polar auxin transport (PAT) proteins nor by treatment with a PAT inhibitor and responded to an auxin signaling inhibitor. However, expression of several auxin biosynthesis genes TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1 (TAA1) was upregulated in cpi1-1. Functionally, TAA1 mutation reduced the auxin response in cpi1-1 and partially rescued its short root phenotype. In support of this genetic evidence, application of cycloeucalenol upregulated expression of the auxin responsive reporter DR5:GUS (β-glucuronidase) and of several auxin biosynthesis genes, while sitosterol repressed their expression. Hence, our combined genetic, pharmacological, and sterol application studies reveal a hitherto unexplored sterol-dependent modulation of auxin biosynthesis during Arabidopsis root elongation.

Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis

2021 ◽  
Author(s):  
Patrick O. Sakyi ◽  
Richard K. Amewu ◽  
Robert N. O. A. Devine ◽  
Alfred K. Bienibuor ◽  
Whelton A. Miller ◽  
...  
Keyword(s):  
Drug Design ◽  
Sterol Biosynthesis

scholarly journals Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.

1977 ◽  
Vol 252 (24) ◽  
pp. 8975-8980 ◽  
Author(s):  
G.J. Schroepfer ◽  
E.J. Parish ◽  
H.W. Chen ◽  
A.A. Kandutsch
Keyword(s):  
Mouse Liver ◽  
Liver Cells ◽  
Sterol Biosynthesis ◽  
L Cells

scholarly journals Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis.

1982 ◽  
Vol 35 (2) ◽  
pp. 230-234 ◽  
Author(s):  
AKINORI MASUDA ◽  
SHIN-ICHI AKIYAMA ◽  
MICHIHIKO KUWANO ◽  
NOBUO IKEKAWA
Keyword(s):  
Amphotericin B ◽  
Sterol Biosynthesis ◽  
Antifungal Effect
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