scholarly journals Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

2021 ◽  
Author(s):  
Montserrat Estruch ◽  
Camilla Vittori ◽  
Teresa Muñoz Montesinos ◽  
Kristian Reckzeh ◽  
Kim Theilgaard-Mönch
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Therapeutic Strategy ◽  
Akt Signaling ◽  
Chemotherapy Response ◽  
Damage Response ◽  
Acute Myeloid ◽  
Novel Therapeutic

scholarly journals Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome

Oncogene ◽  
2009 ◽  
Vol 28 (22) ◽  
pp. 2205-2218 ◽  
Author(s):  
S Boehrer ◽  
L Adès ◽  
N Tajeddine ◽  
W K Hofmann ◽  
S Kriener ◽  
...  
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Damage Response ◽  
Acute Myeloid

scholarly journals Peptide microarray of pediatric acute myeloid leukemia is related to relapse and reveals involvement of DNA damage response and repair

Oncotarget ◽  
2019 ◽  
Vol 10 (45) ◽  
pp. 4679-4690
Author(s):  
Hasan Mahmud ◽  
Arja ter Elst ◽  
Frank J.G. Scherpen ◽  
Tiny Meeuwsen-de Boer ◽  
Kim R. Kampen ◽  
...  
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Peptide Microarray ◽  
Pediatric Acute Myeloid Leukemia ◽  
Damage Response ◽  
Acute Myeloid

P068 Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome

2009 ◽  
Vol 33 ◽  
pp. S98-S99
Author(s):  
S. Boehrer ◽  
L. Ades ◽  
C. Gardin ◽  
W.K. Hofmann ◽  
P. Fenaux ◽  
...  
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Damage Response ◽  
Acute Myeloid

Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth through inhibiting SETD1A/AKT-mediated DNA damage response

2020 ◽  
Author(s):  
Jinzhu Chen ◽  
Juan Feng ◽  
Zhihong Fang ◽  
Jing Ye ◽  
Qinwei Chen ◽  
...  
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Kinase Inhibitor ◽  
Leukemia Cell ◽  
Xenograft Model ◽  
Gene Set Enrichment Analysis ◽  
Damage Response ◽  
Acute Myeloid

Abstract Background: Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL) are highly prevalent in hematological malignancy. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rearranged (MLL-r) leukemias emphasize an urgent need for improved knowledge and novel therapeutic approaches for these malignancies. In this study, we investigated the potential effectiveness and mechanism of Anlotinib, a novel receptor tyrosine kinase inhibitor, in MLL-r acute myeloid leukemia(AML). Methods: MLL-r AML cell lines were treated with different concentration of Anlotinib, then cell viability, apoptosis and cell cycle were analyzed. Next, the anti-leukemia effect of Anlotinib was further evaluated in vivo in a xenograft model of AML-carrying MLL-rearrangement. Finally, we performed RNA-seq analysis, Gene Set Enrichment Analysis (GSEA) and western bolting to explore the underlying mechanism of the anti-leukemia effect of Anlotinib. Results: Our findings revealed that Anlotinib significantly suppresses the growth, promotes robust apoptosis and induces G2/M arrest in MLL-r AML cells. Moreover, Anlotinib effectively inhibited the growth of MLL-r AML cells in a xenograft murine model. In mechanism, we find that the inhibitive role of Anlotinib in MLL-r AML could be largely attributed to the dysfunction of DNA damage and repair. Furthermore, we confirmed that Anlotinib impaired DNA damage response via inhibiting SETD1A and AKT.

scholarly journals Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia?

IUBMB Life ◽  
2018 ◽  
Vol 70 (11) ◽  
pp. 1057-1066
Author(s):  
Rosa Pennisi ◽  
Jacopo Albanesi ◽  
Paolo Ascenzi ◽  
Clara Nervi ◽  
Alessandra di Masi
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Dna Damage Response ◽  
Myeloid Leukemia ◽  
Damage Response ◽  
Acute Myeloid
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