scholarly journals Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma

2020 ◽  
Author(s):  
Aubrey L. Miller ◽  
Patrick L. Garcia ◽  
Tracy L. Gamblin ◽  
Rebecca B. Vance ◽  
Karina J. Yoon
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Patient Derived Xenograft ◽  
Resistant Patient ◽  
Xenograft Models

scholarly journals The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models

Oncogene ◽  
2015 ◽  
Vol 35 (7) ◽  
pp. 833-845 ◽  
Author(s):  
P L Garcia ◽  
A L Miller ◽  
K M Kreitzburg ◽  
L N Council ◽  
T L Gamblin ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Patient Derived Xenograft ◽  
Xenograft Models

An innovative patient-derived xenograft model of pancreatic ductal adenocarcinoma for drug and biomarker discovery

Pancreatology ◽  
2019 ◽  
Vol 19 ◽  
pp. S158-S159
Author(s):  
Arthur Chevallier ◽  
Clélia Costechareyre ◽  
Loraine Jarrosson ◽  
Philippe Chalabreysse ◽  
Raphaël Bourdariat ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Biomarker Discovery ◽  
Xenograft Model ◽  
Ductal Adenocarcinoma ◽  
Patient Derived Xenograft

Establishment of patient-derived tumor xenograft (PDX) model as artificially-created liver metastasis using cryopreserved pancreatic ductal adenocarcinoma.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 729-729
Author(s):  
Kenjiro Kimura ◽  
Ryota Tanaka ◽  
Ryosuke Amano ◽  
Shoji Kubo ◽  
Hiroaki Tanaka ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Liver Transplant ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Tumor Xenograft ◽  
Ductal Adenocarcinoma ◽  
Ki 67 ◽  
Nsg Mice ◽  
Patient Derived Xenograft ◽  
Pdx Model ◽  
Successful Establishment

729 Background: Translational research using patient-derived tumor xenograft (PDX) model is progressing rapidly, and is also becoming widespread in pancreatic cancer research. The purpose of this study was to establish the liver transplant PDX model as artificially-created liver metastasis with cryopreserved primary pancreatic ductal adenocarcinoma(PDAC). Methods: The primary PDAC from 10 patients were cryopreserved and transplanted into NSG mice using liver pocket method. For engraftment and similarity evaluation, H&E staining and immunohistochemical staining such as Ki-67, p53, SMAD4, and MUC1 were performed. Results: Patient-derived xenograft was succeeded in 6 cases (60%), 10 mice (33.3%). Ki-67 index of primary PDAC and the interval of cryopreservation were significantly related to successful engraftment, respectively (p = 0.003, p = 0.007). Conclusions: In this study, we succeeded in establishing a liver transplant PDX mouse model as a preclinical platform. The factors such as Ki-67 index and the interval of cryopreservation would affect the successful establishment.

scholarly journals Personalized Preclinical Trials in BRAF Inhibitor–Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies

2015 ◽  
Vol 22 (7) ◽  
pp. 1592-1602 ◽  
Author(s):  
Clemens Krepler ◽  
Min Xiao ◽  
Katrin Sproesser ◽  
Patricia A. Brafford ◽  
Batool Shannan ◽  
...  
Keyword(s):  
Braf Inhibitor ◽  
Second Line ◽  
Combination Therapies ◽  
Patient Derived Xenograft ◽  
Preclinical Trials ◽  
Resistant Patient ◽  
Xenograft Models
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