scholarly journals Effect of black chokeberry on skeletal muscle damage and neuronal cell death

2019 ◽  
Vol 23 (4) ◽  
pp. 26-31 ◽  
Author(s):  
Jisu Kim ◽  
Kang Pa Lee ◽  
Suji Beak ◽  
Hye Ra Kang ◽  
Yong Kyun Kim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Death ◽  
Muscle Damage ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Skeletal Muscle Damage ◽  
Black Chokeberry

Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning

2006 ◽  
Vol 290 (4) ◽  
pp. C1128-C1138 ◽  
Author(s):  
Elen H. Miyabara ◽  
Jody L. Martin ◽  
Tina M. Griffin ◽  
Anselmo S. Moriscot ◽  
Ruben Mestril
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Muscle Damage ◽  
Neuronal Cell ◽  
Protective Agent ◽  
Wild Type ◽  
Cross Sectional ◽  
Skeletal Muscle Damage ◽  
Neuronal Cell Adhesion Molecule

Heat shock protein expression is elevated upon exposure to a variety of stresses and limits the extent of stress-induced damage. To investigate the putative role of inducible 70-kDa heat shock protein (HSP70) in skeletal muscle damage and regeneration, soleus and tibialis anterior (TA) muscles from HSP70-overexpressing transgenic mice were subjected to cryolesioning and analyzed after 1, 10, and 21 days. Histological analysis showed that the muscles from both HSP70 and wild-type mice treated with radicicol (a HSP inducer) had decreased necrosis after cryolesioning compared with controls. The decrease in muscle fiber cross-sectional area in both soleus and TA muscles in 10 days postlesioning was attenuated in HSP70 mice compared with wild-type mice. Glutathione peroxidase activity was increased 1 day after cryolesioning in both HSP70 and control mice and remained elevated for up to 21 days. Immunodetection of neuronal cell adhesion molecule (a satellite cell marker) and developmental/neonatal MHC were significantly lower in cryolesioned HSP70-overexpressing mice than in cryolesioned controls. These results suggest that HSP70 protects skeletal muscle against injury and radicicol might be useful as a skeletal muscle protective agent.

Fructose-1,6-biphosphate prevents excitotoxic neuronal cell death in the neonatal mouse brain

2003 ◽  
Vol 140 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Marta Rogido ◽  
Isabelle Husson ◽  
Christine Bonnier ◽  
Marie-Christine Lallemand ◽  
Claude Mérienne ◽  
...  
Keyword(s):  
Cell Death ◽  
Mouse Brain ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Neonatal Mouse
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