Protective Effects of Organic Acids against Xanthine/Xanthine Oxidase-Induced Cell Death by Reducing the Intracellular Level of Hydrogen Peroxide

2019 ◽  
Author(s):  
Hung-Yu Chou ◽  
Marie Takahashi ◽  
Aoi Hozono ◽  
Tatsushiro Umehara ◽  
Takashi Nomiya ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Organic Acids ◽  
Xanthine Oxidase ◽  
Protective Effects ◽  
Intracellular Level

scholarly journals Effect of Chitosan Nanoparticle-Loaded Thymus serpyllum on Hydrogen Peroxide-Induced Bone Marrow Stromal Cell Damage

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Salma Baig ◽  
Ainnul Hamidah Syahadah Azizan ◽  
Hanumantha Rao Balaji Raghavendran ◽  
Elango Natarajan ◽  
Sangeetha Naveen ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Cell Damage ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Potential Candidate ◽  
Protective Effects ◽  
Active Components ◽  
Thymus Serpyllum

We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography–mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extracts, the hexane extract showed significant free radical scavenging activity. Treatment of MSCs with H2O2 (hydrogen peroxide) significantly increased intracellular cell death; however, pretreatment with TS extract and nanoparticle-loaded TS (200 μg/ml) suppressed H2O2-induced elevation of Cyt-c and MMP13 and increased the survival rates of MSCs. H2O2-induced (0.1 mM) changes in cytokines were attenuated in the extract and nanoparticles by pretreatment and cotreatment at two time points (p<0.05). H2O2 increased cell apoptosis. In contrast, treatment with nanoparticle-loaded TS suppressed the percentage of apoptosis considerably (p<0.05). Therefore, TS may be considered as a potential candidate for enhancing the effectiveness of MSC transplantation in cell therapy.

Protective Effects of a Diarylheptanoid from Curcuma comosa Against Hydrogen Peroxide-Induced Astroglial Cell Death

Planta Medica ◽  
2016 ◽  
Vol 82 (17) ◽  
pp. 1456-1462 ◽  
Author(s):  
Jaturavit Vattanarongkup ◽  
Pawinee Piyachaturawat ◽  
Patoomratana Tuchinda ◽  
Pimtip Sanvarinda ◽  
Yupin Sanvarinda ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Protective Effects ◽  
Astroglial Cell ◽  
Curcuma Comosa

Protective Effects of the Essential Oil of Salvia fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death

2009 ◽  
Vol 57 (15) ◽  
pp. 6636-6641 ◽  
Author(s):  
Anat Elmann ◽  
Sharon Mordechay ◽  
Miriam Rindner ◽  
Olga Larkov ◽  
Meital Elkabetz ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Essential Oil ◽  
Protective Effects ◽  
Salvia Fruticosa

Protective effects of vacuolar H+-ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells

2007 ◽  
Vol 425 (3) ◽  
pp. 183-187 ◽  
Author(s):  
Yu Jeong Byun ◽  
Seong-Beom Lee ◽  
Dong Jin Kim ◽  
Hwa Ok Lee ◽  
Min Jeong Son ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Protective Effects

Antidepressant Effects of Vaccinium bracteatum via Protection Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis

2018 ◽  
Vol 46 (07) ◽  
pp. 1499-1518 ◽  
Author(s):  
Dool-Ri Oh ◽  
Yujin Kim ◽  
Eun-Jin Choi ◽  
Ara Jo ◽  
Jawon Shin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Damage ◽  
In Vitro Models ◽  
Monoamine Oxidase A ◽  
Protective Effects ◽  
Mao A ◽  
Anti Oxidant

The present study evaluates the anti-oxidative stress activity of Vaccinium bracteatum Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using in vitro models of hydrogen peroxide (H2O[Formula: see text]-induced neuronal damage. The results showed that VBFW treatment (200[Formula: see text]mg/kg) significantly reduced MDA, SERT, and MAO-A levels in the prefrontal cortex of CRS mice. Furthermore, VBFW (30[Formula: see text][Formula: see text]g/mL) exhibited protective effects against H2O2-induced cell death via inhibition of the H2O2-induced increase in Bax and decrease in Bcl-2 levels within the mitochondria of SH-SY5Y cells. Furthermore, VBFW (10 and 30[Formula: see text][Formula: see text]g/mL) exerted protective effects against H2O2-induced cell death through inhibition of key mitochondria-associated apoptotic proteins such as cytochrome c, caspase-3 and PARP. Additionally, VBFW (10 and 30[Formula: see text][Formula: see text]g/mL) could improve the activity of anti-oxidant enzymes (such as SOD and catalase) in H2O2-treated SH-SY5Y cells. These results suggest that the antidepressant and anti-oxidant effects of VBFW might be mediated by the regulation of SERT and MAO-A, and possibly associated with regulation of oxidative stress-induced apoptosis.

The protective effects of oxyresveratrol imine derivative against hydrogen peroxide-induced cell death in PC12 cells

2013 ◽  
Vol 47 (3) ◽  
pp. 212-218 ◽  
Author(s):  
J. Hur ◽  
S. Kim ◽  
P. Lee ◽  
Y. M. Lee ◽  
S. Y. Choi
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Pc12 Cells ◽  
Protective Effects

The role of reactive oxygen metabolites in lymphocyte-mediated cytolysis

1987 ◽  
Vol 87 (3) ◽  
pp. 473-481
Author(s):  
C.J. Bishop ◽  
C.M. Rzepczyk ◽  
D. Stenzel ◽  
K. Anderson
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Xanthine Oxidase ◽  
Natural Killer ◽  
Reactive Oxygen ◽  
Tumour Cells ◽  
Reactive Oxygen Metabolites ◽  
Oxygen Metabolites

To examine the possible role of reactive oxygen metabolites in lymphocyte-mediated cytolysis, the morphology of cell death following the exposure of cells to reactive oxygen metabolites in vitro was compared with the morphology of cell-mediated killing in vitro of tumour cells by natural killer (NK) cells. Ultrastructural examination of human tumour cells that were dying following incubation for 60 min with the oxygen metabolite generating systems, xanthine-xanthine oxidase or t-butylhydroperoxide, showed that cell death in both instances was exclusively by necrosis. It was unclear which oxygen metabolites were involved in killing. Cell death was not decreased by the addition of superoxide dismutase, a scavenger of the superoxide anion, to the xanthine-xanthine oxidase mixture. Although the cells were not killed by incubation with 1 mM-hydrogen peroxide, the addition of catalase, a scavenger of hydrogen peroxide, to the xanthine-xanthine oxidase mixture significantly reduced cell death. The addition of scavengers for the hydroxyl radical to either the xanthine-xanthine oxidase mixture or t-butylhydroperoxide gave inconsistent protection. In contrast, tumour cell killing mediated by natural killer cells was by apoptosis, a morphologically distinct mode of cell death with a different basic mechanism, indicating that reactive oxygen metabolites are not directly involved in lymphocyte-mediated cytolysis.

scholarly journals Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide

2018 ◽  
Vol 12 (2) ◽  
pp. 93 ◽  
Author(s):  
Ah Young Lee ◽  
Ji Myung Choi ◽  
Myoung Hee Lee ◽  
Jaemin Lee ◽  
Sanghyun Lee ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Linolenic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Protective Effects ◽  
Alpha Linolenic Acid ◽  
Perilla Oil
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