scholarly journals Myocardial infarction and angina pectoris in the history of Polish medicine. Part 1. Discovery and understanding of the disease

2008 ◽  
Vol 118 (4) ◽  
pp. 243-247
Author(s):  
Janusz H. Skalski
Keyword(s):  
Myocardial Infarction ◽  
Angina Pectoris ◽  
History Of

PRIMARY XANTHOMA TUBEROSUM IN CHILDREN

PEDIATRICS ◽  
1959 ◽  
Vol 23 (1) ◽  
pp. 67-75
Author(s):  
Jack E. McCleary ◽  
Louis A. Brunsting ◽  
Roger L. J. Kennedy
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Angina Pectoris ◽  
Cardiac Disease ◽  
Blood Lipids ◽  
Close Relative ◽  
History Of ◽  
Coronary Blood Vessels ◽  
The One

A brief classification of xanthomatoses is presented. In an attempt to remove some of the confusion contributed by the several different meanings for the term "hyperlipemia," the term "hyperneutralipemia" is introduced to indicate an elevation of the concentrations of neutral fat in the serum. The term "hyperlipemia" is retained to mean an elevation of values for any of the blood lipids. The term "primary xanthoma tuberosum" designates the classic idiopathic form of xanthoma tuberosum associated with hypercholesteremia and without hyperneutralipemia. The primary purpose of this paper is to review the outcome of 11 cases of primary xanthoma tuberosum in children seen at the Mayo Clinic. Five of the eleven are known to be dead from cardiovascular disease, and one other is presumed to be dead. In five of the six patients angina pectoris developed before death. Two patients who are still living have angina pectoris, one having suffered myocardial infarction. Necropsy of four patients showed atheromatous involvement of the coronary blood vessels to be a prominent finding. Three of the patients died before they reached the age of 15 years. Two of the patients were brother and sister. Of the remaining nine patients, four gave a family history of cardiac disease occurring in a close relative early in life and five patients had relatives with cutaneous xanthomas. In the one family studied, all five members had hypercholestenemia.

Prothrombin Activation Fragment 1 + 2 and Thrombin Antithrombin III Complexes in Patients with Angina Pectoris: Relation to the Presence and Severity of Coronary Atherosclerosis

1993 ◽  
Vol 70 (04) ◽  
pp. 550-553 ◽  
Author(s):  
J Kienast ◽  
S G Thompson ◽  
C Raskino ◽  
H Pelzer ◽  
C Fechtrup ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Angina Pectoris ◽  
Coronary Atherosclerosis ◽  
Antithrombin Iii ◽  
Past History ◽  
Oral Anticoagulant Therapy ◽  
Oral Anticoagulants ◽  
Positive Association ◽  
History Of ◽  
Prothrombin Activation

SummaryPlasma levels of the prothrombin activation fragment 1 + 2 (F 1 + 2) and of thrombin antithrombin III complexes (TAT) were determined in 225 patients with angina pectoris undergoing coronary angiography. Oral anticoagulant therapy was associated with a marked reduction in mean Fl + 2 (0.63 vs 1.62 nmol/l, p <0.0001) and TAT levels (1.65 vs 2.23 μg/1, p <0.0001). Omitting patients on oral anticoagulants, TAT values showed a positive association with patients’ age (r = 0.18; p = 0.01) and were slightly higher in patients with a history of myocardial infarction than in those without (2.47 vs 2.11 <g/l; p = 0.06). Both Fl + 2 and TAT levels were increased in patients with angiographically verified coronary atherosclerosis as compared to patients with angina and angiographically normal coronaries (Fl + 2: 1.76 vs 1.36 nmol/1, TAT: 2.35 vs 2.00 μg/1; p-values after adjusting for age, sex and past history of myocardial infarction 0.06 and 0.11 respectively). However, no graded relationship between Fl + 2 or TAT values and severity of atherosclerosis was observed. This study provides suggestive evidence that a procoagulant state exists in patients with angina pectoris and coronary atherosclerosis. Its relevance in predicting coronary ischaemic events needs to be studied prospectively.

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