scholarly journals Metformin added to intensive insulin therapy reduces plasma levels of glycated but not oxidized low‑density lipoprotein in young patients with type 1 diabetes and obesity in comparison with insulin alone: a pilot study

2013 ◽  
Vol 123 (10) ◽  
pp. 526-532 ◽  
Author(s):  
Paweł Burchardt ◽  
Agnieszka Zawada ◽  
Piotr Tabaczewski ◽  
Dariusz Naskręt ◽  
Jolanta Kaczmarek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pilot Study ◽  
Intensive Insulin Therapy ◽  
Low Density Lipoprotein ◽  
Young Patients ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Diabetes And Obesity

Vitamin D levels are associated with low-density lipoprotein cholesterol in Chinese children with type 1 diabetes

2021 ◽  
Author(s):  
Jianbo Shu ◽  
Xinhui Wang ◽  
Mingying Zhang ◽  
Xiufang Zhi ◽  
Jun Guan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Nonlinear Relationship ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Vitamin D Levels

Abstract Objective There is an increased level of low-density lipoprotein cholesterol (LDL-C)in children with type 1 diabetes mellitus(T1DM). In addition, the Vitamin D level in T1DM patients is usually below the normal reference range. The aim of this study was to explore the relationship between Vitamin D levels and LDL-C in Chinese children with T1DM. Methods A retrospective cross-sectional study was conducted in the Endocrine inpatient wards of Tianjin Children’s Hospital, 143 children with T1DM were included. The related clinical and laboratory examinations, including anthropometric parameters, lipid profiles, and Vitamin D levels, were collected in all subjects. Results The univariate analysis results did not show a significant correlation between Vitamin D levels and LDL-C (P=0.634). Furthermore, a nonlinear relationship was observed between Vitamin D levels and LDL-C by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant negative association between LDL-C and Vitamin D levels when LDL-C was greater than 3.1 mmol/L(β -2.9, 95% CI -5.4,-0.5; P=0.022). However, we did not observe a significant relationship between LDL-C and Vitamin D levels when LDL-C was lower than 3.1 mmol/L(β 2.4, 95% CI -0.2,5.1; P=0.076).Conclusions This study identified a nonlinear relationship between Vitamin D levels and LDL-C independent of other potential confounding factors, suggesting that the deficiency or insufficiency of Vitamin D in T1DM children with high LDL-C levels should be considered, especially LDL-C is higher than 3.1 mmol/L, which provides evidence of the timing about Vitamin D supplementation in T1DM children.

scholarly journals Lipoprotein-associated phospholipase A2 activity and low-density lipoprotein subfractions after a 2-year treatment with atorvastatin in adolescents with type 1 diabetes

2016 ◽  
Vol 29 (10) ◽  
Author(s):  
Andreas Krebs ◽  
Juergen Doerfer ◽  
Alexandra Krause ◽  
Juergen Grulich-Henn ◽  
Martin Holder ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Pla2 Activity ◽  
Apo B ◽  
Small Dense Ldl ◽  
Long Term Treatment

AbstractBackground:The objective of the study was to assess the effect of atorvastatin on inflammation markers and low-density lipoprotein (LDL) subfractions.Methods:In a prospective, randomized, double-blind pilot study involving 28 adolescents with type 1 diabetes (T1D), lipoprotein-associated phospholipase AResults:For the atorvastatin group, we found posttreatment reductions of Lp-PLA2 activity (p<0.001), LDL cholesterol (p=0.001), non-small dense LDL cholesterol (p<0.001), total cholesterol (p<0.001), and apolipoprotein B (apo B) (p<0.001), whereas small dense LDL cholesterol and hsCRP did not change significantly.Conclusions:In adolescents with T1D, long-term treatment with atorvastatin is safe and may reduce cardiovascular risk by significant decreases of Lp-PLA2 activity and LDL cholesterol.

Reply to “Bioinformatics analysis in type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta”

2017 ◽  
Vol 263 ◽  
pp. 428-429
Author(s):  
Mette K. Hagensen ◽  
Martin Bødtker Mortensen ◽  
Mads Kjolby ◽  
Ninna L. Stillits ◽  
Lasse B. Steffensen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bioinformatics Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Prone Area

scholarly journals Plasma Oxidized Low-Density Lipoprotein Is an Independent Risk Factor in Young Patients with Coronary Artery Disease

2011 ◽  
Vol 31 (5) ◽  
pp. 295-301 ◽  
Author(s):  
Yuli Huang ◽  
Yunzhao Hu ◽  
Weiyi Mai ◽  
Xiaoyan Cai ◽  
Yuanbin Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Independent Risk Factor ◽  
Low Density Lipoprotein ◽  
Young Patients ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Male Sex ◽  
Artery Disease ◽  
Conventional Risk Factors

Objectives:Oxidized low-density lipoprotein (ox-LDL) is considered to be a key factor of initiating and accelerating atherosclerosis. The objective of this study was to investigate the role of ox-LDL in young patients with coronary artery disease (CAD).Methods:128 consecutive angiographically proven young CAD patients (aged ≤ 55 years) were enrolled, and 132 age-matched non-CAD individuals (coronary angiography normal or negative finding by coronary ultrafast CT) were set as control group. Conventional risk factors (hypertension, dyslipidemia, diabetes mellitus, obesity, smoking) were evaluated in the two groups. Ox-LDL was measured by competitive ELISA. Framingham risk score (FRS) and absolute 10-year CAD events risk were calculated for each individual.Results:Male sex was more prevalent in group CAD than in control (87.5% vs. 62.1%;P< 0.01). There were significant differences in smoking history (P< 0.01) and triglyeride (TG) and ratio of apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) (bothP< 0.05) but no remarkable difference in other conventional risk factors (allP> 0.05) between group CAD and control. Level of ox-LDL was significantly higher in group CAD than in control (P < 0.01). Multivariate logistic regression showed that male sex (OR, 4.54; 95%CI, 1.76–9.77), smoking quantity (OR, 2.78; 95%CI, 1.34–4.25), TG (OR, 1.42; 95%CI, 1.18–2.83), ApoB/ApoA1 (OR, 1.73; 95%CI, 1.32–4.23), and ox-LDL (OR, 2.15; 95%CI, 1.37–6.95) were independently correlated with CAD in young patients. Area under the curve (AUC) of receiver operating characteristic (ROC) curve of TG, ApoB/ApoA1, and ox-LDL was 0.831, 0.866, and 0.935, respectively (P< 0.001).Conclusions:Ox-LDL is an important independent risk factor for CAD in young patients after adjusting other risk factors such as smoking, TG, and ApoB/ApoA1.

In vivo glycated low-density lipoprotein is not more susceptible to oxidation than nonglycated low-density lipoprotein in type 1 diabetes

Metabolism ◽  
2004 ◽  
Vol 53 (8) ◽  
pp. 969-976 ◽  
Author(s):  
Alicia J Jenkins ◽  
Suzanne R Thorpe ◽  
Nathan L Alderson ◽  
Kathie L Hermayer ◽  
Timothy J Lyons ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density
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