scholarly journals Cardiovascular therapy, diagnostic procedures, and control of risk factors in patients with diabetes or coronary artery disease in Poland: the Kardia‑Pol registry

2012 ◽  
Vol 122 (9) ◽  
pp. 413-421
Author(s):  
Grzegorz Opolski ◽  
Krzysztof Strojek ◽  
Michał Kurzelewski ◽  
Maciej Ostrowski ◽  
Daniel Rabczenko
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diagnostic Procedures ◽  
Cardiovascular Therapy ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
And Control

scholarly journals Clinical manifestations and risk factors of coronary artery disease in patients with diabetes mellitus in western Siberia

2010 ◽  
Vol 69 (3) ◽  
pp. 278-284
Author(s):  
Vadim A. Kuznetsov ◽  
Elena I. Yaroslavskaya ◽  
Marina I. Bessonova ◽  
Ivan S. Bessonov ◽  
Igor P. Zyrianov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Western Siberia ◽  
Clinical Manifestations ◽  
Patients With Diabetes ◽  
Artery Disease

Risk factors for lack of statin therapy in patients with diabetes and coronary artery disease

2016 ◽  
Vol 10 (6) ◽  
pp. 1406-1413 ◽  
Author(s):  
Huabing Zhang ◽  
Jorge Plutzky ◽  
Maria Shubina ◽  
Alexander Turchin
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Statin Therapy ◽  
Patients With Diabetes ◽  
Artery Disease

scholarly journals Coronary Artery Disease Risk Factors among Employees of Shahid Gangalal National Heart Centre, Kathmandu, Nepal

2015 ◽  
Vol 12 (2) ◽  
pp. 79-81
Author(s):  
Sunita Pokhrel ◽  
Pushpa Neupane
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Risk ◽  
Individual Risk ◽  
Targeted Interventions ◽  
National Heart ◽  
Single Centre Study ◽  
Artery Disease ◽  
And Control

Background and Aims: As employees spent most part of their time at the worksite, it provides a venue to address multiple individual risk factors and promote health. We aim to assess the prevalence of risk factors for coronary artery disease among the employees of Shahid Gangalal National Heart Centre, Kathmandu, Nepal.Methods: It was a prospective, single centre study conducted among randomly selected 129 (35.15%) out of 367 employees of our centre. All selected employees were subjected to detailed blood pressure, anthropometric and metabolic parameters measurement to identify risk factors. Results: Among the 129 participant 85(65.9%) were female and 44(34.1%) were male. Mean age was 25.8 years. Most of the patients 93(72%) were below the age of 40 years. Based upon BMI, 64(49.6%) were overweight, 20 (15.5%) were Obese, normal BMI was found in 38(29.9 %) where as underweight was found in 7(5.4%) employee. Based upon Central waist circumference Central waist obesity was common in female than male. Only 10(7.8%) of the employee were found to be hypertensive. Nineteen (14.7%) employee had RBS of ?125mg/dl.Conclusions: The high prevalence of risk factors of coronary artery disease is alarming. There should be the urgent and targeted interventions to prevent, treat and control non communicable diseases and their risk factors.Nepalese Heart Journal 2015;12(2):79-81

Association between periodontal disease and coronary artery disease

Open Medicine ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. 308-314
Author(s):  
Mohammad Zibaeenezhad
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Periodontal Disease ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Dental Infection ◽  
Male And Female ◽  
Artery Disease ◽  
And Control

AbstractThe etiology of coronary artery disease (CAD) is multifunctional. There is increasing evidence that dental infections could play a role in the initiation and development of CAD. In a case control double blind study, one hundred male and female (mean age 51 ± 9.4) angiographically documented CAD, compared with one hundred male and female patients (mean age 50.6 ± 9) with angiographically negative coronary artery. All the patients (cases and control) underwent dental examination for the presence and severity of periodontitis by a dentist who was oblivious the result of the angiography performed. The association between periodontal disease status and CAD was significant (P=0.011); periodontitis was apparently more frequent in CAD positive patients than in control (86% versus 61%). Adjustment of coronary risk factors (smoking, DM, hypertension and hyperlipidemia) in both cases and control groups suggests that the association between periodontitis and CAD in our study was independent of coronary risk factors. There is increasing evidence that dental infection, especially aerobic organisms which have capability of aggregation of platelets, is the most important cause. Dental infection would be an independent risk factor for CAD.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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