scholarly journals Anti-oxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa multiflora Root Extracts

2017 ◽  
Vol 15 (2) ◽  
pp. 146-158 ◽  
Author(s):  
Hyeon Sook Hwang ◽  
Tae Hyun Hwang ◽  
Ae Ja Pyo ◽  
Eun Hwa Ju
Keyword(s):  
Growth Factors ◽  
Hair Follicle ◽  
Human Hair ◽  
Dermal Papilla ◽  
Rosa Multiflora ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Root Extracts ◽  
Anti Oxidant

scholarly journals Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

2020 ◽  
Vol 21 (21) ◽  
pp. 8054
Author(s):  
Soyoon Park ◽  
Wesuk Kang ◽  
Dabin Choi ◽  
Bomin Son ◽  
Taesun Park
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Hair Follicle ◽  
Human Hair ◽  
Cyclic Adenosine Monophosphate ◽  
Dermal Papilla ◽  
Adenosine Monophosphate ◽  
Dependent Manner ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells

Human hair follicle dermal papilla cells (DPCs) are a specialized population of cells located in the hair follicles and regulate hair growth and development, particularly by releasing numerous growth factors in response to various physiological conditions. In the present study, we aimed to test whether nonanal, a scent compound from plants, stimulated growth factors in DPCs and to delineate the underlying mechanisms involved. We found that nonanal promoted DPC proliferation in a dose-dependent manner. Meanwhile, it also increased the intracellular cyclic adenosine monophosphate (cAMP) levels and the expression of various growth factor genes such as vascular endothelial growth factor, keratinocyte growth factor, and insulin-like growth factor 1. Furthermore, nonanal treatment stimulated DPC migration. Notably, the benefits of nonanal use were abrogated by cAMP inhibition. Our results reveal the potential of nonanal in preventing hair loss and suggest that its effects are cAMP-mediated in DPCs.

scholarly journals Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells

2012 ◽  
Vol 132 (6) ◽  
pp. 1725-1727 ◽  
Author(s):  
Claire A. Higgins ◽  
Munenari Itoh ◽  
Keita Inoue ◽  
Gavin D. Richardson ◽  
Colin A.B. Jahoda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Hair Follicle ◽  
Pluripotent Stem Cells ◽  
Human Hair ◽  
Dermal Papilla ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Induced Pluripotent

Preservation of a specialized phenotype of dermal papilla cells of a human hair follicle under cultivation conditions

2017 ◽  
Vol 44 (4) ◽  
pp. 363-371
Author(s):  
E. P. Kalabusheva ◽  
E. S. Chermnykh ◽  
V. V. Terskikh ◽  
E. A. Vorotelyak
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Dermal Papilla ◽  
Cultivation Conditions ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells

scholarly journals Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9867
Author(s):  
Ke Sha ◽  
Mengting Chen ◽  
Fangfen Liu ◽  
San Xu ◽  
Ben Wang ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Follicle Growth ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Platelet Factor ◽  
Hair Follicle Growth

Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells in vitro and via hair follicle organ culture. Among the hair growth-promoting and DP-signature genes investigated, PF4 decreased the expression of Wnt5a, Wnt10b, LEF1, HEY1 and IGF-1, and increased DKK1 expression, but did not affect BMP2 and BMP4 expression. Collectively, Our data demonstrate that PF4 suppresses human hair follicle growth possibly via upregulating androgen receptor signaling and modulating hair growth-associated genes, which provides thought-provoking insights into the application and optimization of PRP in treating hair loss.

scholarly journals Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells

2021 ◽  
Vol 69 (5) ◽  
pp. 464-471
Author(s):  
Toshio Morikawa ◽  
Yoshiaki Manse ◽  
Fenglin Luo ◽  
Haruko Fukui ◽  
Yamato Inoue ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Proliferative Activity ◽  
Dermal Papilla ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells
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