scholarly journals Association of S100B Serum Levels with Metabolic Syndrome and its Components

2018 ◽  
Vol 31 (4) ◽  
pp. 201 ◽  
Author(s):  
Sorayya Kheirouri ◽  
Elham Ebrahimi ◽  
Mohammad Alizadeh
Keyword(s):  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Healthy Subjects ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Serum Levels ◽  
S100b Protein ◽  
Control Group ◽  
Cardiovascular Disorders

Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome.Materials and Methods: In this study, 44 patients with metabolic syndrome and 44 healthy subjects participated. The participants’ body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low and high density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood glucose, insulin, S100B protein were determined by enzymatic and ELISA methods.Results: The participants with metabolic syndrome had significantly higher levels of S100B than those in the control group (p < 0.0001). Serum levels of S100B protein were positively correlated with abdominal obesity (rho = 0.26; p = 0.01) and serum levels of triglyceride (rho = 0.26; p = 0.01). Moreover, serum levels of S100B were higher in subjects with abdominal obesity (p = 0.02), with higher serum triglyceride levels (p = 0.03) and with hypertension (p = 0.01).Conclusion: The findings indicate that there may be a link between S100B protein with abdominal obesity and serum levels of triglycerides. This warrants further research to elucidate whether increased S100B levels in patients with metabolic syndrome are involved in the pathogenesis of cardiovascular disorders.

Down-regulation of S100A1 protein in patients with metabolic syndrome and its association with zinc-α2-glycoprotein

2017 ◽  
Vol 62 (3) ◽  
pp. 88-95 ◽  
Author(s):  
Elham Ebrahimi ◽  
Sorayya Kheirouri ◽  
Mohammad Alizadeh
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Multiple Testing ◽  
Density Lipoprotein ◽  
Serum Zinc ◽  
Serum Levels ◽  
Control Group ◽  
Strong Positive Correlation ◽  
The Metabolic Syndrome ◽  
Equivalent Number

Objectives It has been proposed that zinc-α2-glycoprotein and S100A1 are possibly linked to the development of lipogenesis and obesity. We aimed to measure serum levels of S100A1 and zinc-α2-glycoprotein in patients with metabolic syndrome and investigate any associations of these two novel peptides with each other or components of metabolic syndrome. Methods Forty-four patients with metabolic syndrome and the equivalent number of healthy controls participated in this study. The participants’ body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low- and high-density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood sugar, insulin, zinc-α2-glycoprotein and S100A1 protein were determined. Results Higher levels of anthropometric and lipid indices, metabolic factors and also SBP and DBP were observed in the metabolic syndrome group. Serum S100A1 levels were significantly lower in the metabolic syndrome group than the control group ( P = 0.008). There was a strong positive correlation between serum zinc-α2-glycoprotein and S100A1 levels ( r = 0.80, P < 0.0001). Serum levels of both S100A1 ( P = 0.03) and zinc-α2-glycoprotein ( P = 0.02) were potentially higher in subjects with hypertension than those with normal blood pressure, though these were found as part of multiple testing. Conclusion The results indicate that changes in the circulating level of S100A1 protein occur in metabolic syndrome patients. The strong correlation between serum zinc-α2-glycoprotein and S100A1 might suggest that production or release of these two proteins could be related mechanistically.

scholarly journals Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters

2019 ◽  
Author(s):  
SELMA KORKMAZ ◽  
GÜLBEN SAYILAN ÖZGÜN
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Regulation ◽  
Psoriasis Vulgaris ◽  
Fasting Blood Glucose ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Metabolic Parameters ◽  
Lipoprotein Cholesterol ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group

Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS). Methods: Fifty-three patients and twenty-six healthy controls were included in this study. Serum adropin levels, fasting blood glucose, fasting plasma insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglyceride levels of all participants were analyzed. Enzyme-linked immunosorbent assay was used to measure serum adropin levels. Results: Serum adropin levels in psoriatic patients without MetS were 2.94±0.56 ng/ml, in psoriasis patients with MetS were 2.49±0.77 ng/ml and were 3.37±0.71 ng/ml in control group. Multivariate logistic regression analysis was used to evaluate adropin decreases in psoriasis patients as an independent predictor in terms of the presence of MetS. Conclusion: The serum levels of adropin in psoriasis patients were significantly lower in the presence of MetS, and this decrease was more prominent than in those without MetS. Adropin may be a responsible factor for metabolic disorders and the development of MetS in psoriasis patients. Key words: Psoriasis, metabolic syndrome, adropin

Effect and Mechanism of Virechana Karma (Therapeutic Purgation) Over Fructose-Induced Metabolic Syndrome

2015 ◽  
Vol 21 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Ashutosh Chaturvedi ◽  
Prasanna N. Rao ◽  
M. Ashvini Kumar ◽  
B. Ravishankar ◽  
Niranjan Rao ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Animal Experiments ◽  
Serum Triglyceride ◽  
Positive Control ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
The Metabolic Syndrome ◽  
Obesity And Diabetes

Background. Panchakarma (biopurification methods) is one of the modes of ayurveda to treat disorders of the body. Virechana karma (therapeutic purgation), one among the Panchakarma, is a purification process that is commonly used to treat metabolic disorders like obesity and diabetes mellitus. Hence this study was planned to provide evidence through animal experiments. Methods. Albino rats were subject to Virechana karma (therapeutic purgation) to evaluate the influence of therapy and its mechanism over fructose-induced metabolic syndrome. Results. Results show that Virechana is effective in the management of the metabolic syndrome with decrease in the fecal fat content, fasting blood glucose, serum triglyceride, and reduced fatty changes in liver, heart, and kidney in comparison with the positive control group. Conclusion. Experimental evaluation showed decrease in fatty acid in the storage like liver, kidney, heart, and muscle adipose tissue can indirectly increase the insulin sensitivity in insulin receptor present at skeletal muscles.

scholarly journals Association of VEGF +405 C > G (rs2010963) polymorphism with susceptibility of metabolic syndrome: Cardio-metabolic risk factors and serum Matrix Metaloproteinase-3 concentrations

2021 ◽  
Vol 19 (3) ◽  
pp. 263-271
Author(s):  
Leila Nikniaz ◽  
Mahdieh Abbasalizad-Farhangi
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Gene Polymorphism ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Control Group ◽  
Vegf Gene ◽  
Pcr Rflp ◽  
Elisa Technique ◽  
Vegf Gene Polymorphism

BACKGROUND: In the present study we investigated the role of +405 VEGF gene polymorphism in the pathogenesis of metabolic syndrome and to explore its association with several biochemical risk factors. MATERIALS AND METHODS: VEGF +405 single nucleotide polymorphism were genotyped in 150 patients with metabolic syndrome and 50 healthy individuals using the PCR-RFLP method. Serum levels of biochemical variables were assessed by commercial ELISA technique. RESULTS: GC genotype was more prevalent among patients with metabolic syndrome. In GC genotype, patients with metabolic syndrome had higher waist to hip ratio, WHR, triglyceride, and lower high density lipoprotein and alanine aminotransferase concentrations compared with the control group. CONCLUSIONS: The current study demonstrated that +405 VEGF gene polymorphism was a potent predictor of metabolic abnormalities in patients with metabolic syndrome. Further studies with larger sample size are needed to clarify these associations properly.

scholarly journals What is the role of profibrogenic and proinflammatory factors in developing atrial fibrillation associated with metabolic syndrome components?

2021 ◽  
Vol 26 (11) ◽  
pp. 4752
Author(s):  
V. A. Ionin ◽  
E. I. Barashkova ◽  
V. A. Pavlova ◽  
G. I. Borisov ◽  
K. A. Averchenko ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Healthy Subjects ◽  
Metabolic Diseases ◽  
Inflammatory Biomarkers ◽  
Control Group ◽  
Galectin 3 ◽  
Laboratory Investigations

Aim. To determine the concentration of blood fibrotic and inflammatory biomarkers in patients with atrial fibrillation (AF) associated with metabolic syndrome (MS) components.Material and methods. The study included 646 patients aged 35-65 years: patients with AF and MS (n=142), those with AF and without MS (n=113), those with MS and without AF (n=175) and the control group consisted of healthy subjects without cardiovascular and metabolic diseases (n=107). All participants underwent anthropometric and laboratory investigations. Profibrogenic (aldosterone, galectin-3, TGF-beta1, CTGF) and proinflammatory (CT-1, IL-6) factors were determined in serum and plasma by ELISA. Statistical analysis was performed using IBM SPSS Statistics software (version 22.0).Results. The highest concentrations of fibrotic and inflammatory biomarkers were found in patients with AF in combination with MS. In MS patients without AF, the concentration of aldosterone, galectin-3, TGF-beta1, CTGF, CT-1, and IL-6 was also higher than in healthy subjects. The levels of aldosterone, CT-1 and IL-6 in patients with AF were higher in the presence of three or more MS components, while the highest values of these parameters were found in patients with five MS components. The lowest concentrations of galectin-3, CTGF, and CT-1 in patients with AF were found in patients without MS components, and in the presence of even 1 MS component, they were significantly higher. Correlation analysis made it possible to establish a stronger relationship between aldosterone and TGF-betal with systolic blood pressure (p=0,493, p<O,O001 and p=0,530, p<O,O001), and CT-1, CTGF and IL-6 in a greater degree correlated with waist circumference (p=0,563, p<0,0001; p=0,626, p<0,0001; p=0,480, p<O,O001). The concentrations of galectin-3 and CTGF were more positively correlated with an increase in the number of MS components. In patients with AF and hypertension (HTN), but without abdominal obesity (AO), higher values of aldosterone (108,1±70,3 pg/ml and 89,3±32,2 pg/ml, p=0,003) and TGF-beta1 (3680,1±1863,3 pg/ml and 1968,1±1611,5 pg/ml, p=0,015) in serum than in AF patients without HTN and without AO. In the group of patients with AF and AO, but without HTN, higher concentrations of IL-6 (2,9±0,7 pg/ml and 1,9±0,6 pg/ml, p=0,001) and CTGF (162,9±92,2 pg/ml and 116,3±63,4 pg/ml, p=0,0001).Conclusion. It can be assumed that hypertension through the aldosterone system and TGF-beta1, as well as abdominal obesity through the cytokine system CT-1 and IL-6 activate various mechanisms and pathways for myocardial remodeling. Integral molecules galectin-3 and CTGF mediate their interactions, in particular in patients with a combination of several MS components and contribute to a higher AF risk.

scholarly journals Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study

2020 ◽  
Vol 8 (3) ◽  
pp. 38
Author(s):  
Ariunbold Chuluun-Erdene ◽  
Orgil Sengeragchaa ◽  
Tsend-Ayush Altangerel ◽  
Purevjal Sanjmyatav ◽  
Batnaran Dagdan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Control Group ◽  
Case Group ◽  
Individual Snps ◽  
Increased Risk

Metabolic syndrome (MetS) is complex and determined by the interaction between genetic and environmental factors and their influence on obesity, insulin resistance, and related traits associated with diabetes and cardiovascular disease risk. Some dynamic markers, including adiponectin (ADIPOQ), brain-derived neurotrophic factor (BDNF), and lipoprotein lipase (LPL), are implicated in MetS; however, the influence of their genetic variants on MetS susceptibility varies in racial and ethnic groups. We investigated the association of single nucleotide polymorphism (SNP)-SNP interactions among nine SNPs in six genes with MetS’s genetic predisposition in Mongolian subjects. A total of 160 patients with MetS for the case group and 144 healthy individuals for the control group were selected to participate in this study. Regression analysis of individual SNPs showed that the ADIPOQ + 45GG (odds ratio (OR) = 2.09, p = 0.011) and P+P+ of LPL PvuII (OR = 2.10, p = 0.038) carriers had an increased risk of MetS. Conversely, G allele of LPL S447X (OR = 0.45, p = 0.036) and PGC-1α 482Ser (OR = 0.26, p = 0.001) allele were estimated as protective factors, respectively. Moreover, a haplotype containing the G-P+-G combination was related to MetS. Significant loci were also related to body mass index (BMI), systolic blood pressure (SBP), serum high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and fasting blood glucose (FBG), adipokines, and insulin as well as insulin resistance (p < 0.05). Our results confirm that ADIPOQ + 45T > G, LPL PvII, and PGC-1α Gly482Ser loci are associated with MetS in Mongolian subjects.

scholarly journals Hubungan pola makan dengan sindroma metabolik pada karyawan PT.Unocal oil company di offshore Balikpapan Propinsi Kalimantan Timur

2007 ◽  
Vol 4 (2) ◽  
pp. 63
Author(s):  
Sri Sudarminingsih ◽  
Wiryatun Lestariana ◽  
Susetyowati Susetyowati
Keyword(s):  
Metabolic Syndrome ◽  
Energy Intake ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Food Habit ◽  
Case Control ◽  
Control Group ◽  
Total Carbohydrate ◽  
Logistic Regressions ◽  
Oil Company

Background: Prevalence of metabolic syndrome has significantly increased in both developed and developing countries. Criteria of metabolic syndrome includes: body mass index of > 27, and male waist circumference of > 102 cm which could be followed by fasting blood glucose level of >110 mg/dl. Other symptoms are blood pressure and triglyceride (of > 130/85 mm Hg and > 150 mg/dl respectively) and decrease in high density lipoprotein to < 40 mg/dl.Objective: This research was aimed to explore the extent to which food habit relates with metabolic syndrome among offshore workers employed by Unocal Oil Company Ltd. Located in Balikpapan.Method: The study which was an observational-analytical was then carried out using case-control design, with comparison 1:1 (matched case control). Nutrients intake measured using the 3 x 24 hours recall method. Chi squares, t- test, odd ratios, and logistic regressions were performed to determine statistical significant among variables.Result: The study showed that energy intake > 110% recommended daily allowance (RDA) between case and control group was significantly different (OR= 7.7; 95% CI= 3.1-18.8). This was also true for the case of total carbohydrate > 60%, (OR= 3.98, 95% CI= 1.6-9.8), refined carbohydrate > 5% (OR= 7.4; 95% CI= 2.9-18.7), total protein > 20% (OR= 3.2; 95% CI= 1.2-8.4), and fat > 20% (OR= 5.04; 95% CI= 1.578-16.1). Logistic regressions were performed to determine statistical significant among variables candidate and the result showed it was significant for refined carbohydrate, energy intake and old work in offshore (p<0.05).Conclusion: This study indicate that nutrient intake was higher than of RDA, it was closely related to the incidence of metabolic syndrome: refined carbohydrate, energy intake and old offshore workers employed (p < 0.05).

scholarly journals Evaluation of serum asprosin levels in women with metabolic syndrome in Duhok City-Kurdistan Region/Iraq

2021 ◽  
Vol 9 (8) ◽  
pp. 2240
Author(s):  
Dhia M. Sulaiman
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Demographic Data ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Control Group ◽  
Fasting Insulin ◽  
Kurdistan Region ◽  
Cross Sectional ◽  
Significant Difference

Background: Serum asprosin, a recently discovered hormone as a new adipocytokine, which has been associated with the regulation of both glucose and lipid metabolism, and insulin resistance. Metabolic syndrome considered as a disorder of lipid and glucose metabolism, with impairment in insulin function, which might be associated with serum asprosin, therefore, new researches focused on the role of asprosin in the pathogenesis of metabolic syndrome to clarify such relationship. This study aimed to evaluate serum asprosin levels in women with metabolic syndrome and compared with a woman without metabolic syndrome.Methods: This study was performed at Obstetrics and Gynecology Hospital, and Mazi medical clinics in Duhok, Kurdistan Region-Iraq, the study was established from June, 2020 to January, 2021. In this cross-sectional study, serum asprosin concertation in 40 women with metabolic syndrome were compared with a 131 women without metabolic syndrome. The demographic data were collected, serum asprosin levels, lipid profile, fasting blood glucose, fasting insulin were biochemically analyzed by using the autoanalyzer machine COBASS series 6000 and ELISA technique.Results: The mean age of women with metabolic syndrome was (24.36±3.23) and women without metabolic syndrome was (23.18±3.87), serum aspersion in women with metabolic syndrome was (18.34±5.4) ng/ml, while in women without metabolic syndrome was (7.48±5.82) with significant difference (p<0.001). In study population, there was a positive correlation between asprosin and body mass index, waist circumference, triglyceride, total cholesterol, fasting blood glucose, fasting insulin, and HOMA-IR (p<0.0001), while serum asprosin was negatively correlated with high density lipoprotein- cholesterol (p<0.01).Conclusions: The study confirms that serum asprosin in women with metabolic syndrome was higher than in the control group.  

scholarly journals Impact of Dietetic Intervention on Metabolic Syndrome Patients Attending Diet Therapy Clinic: A prospective, Single-Arm Intervention Study

2021 ◽  
Vol 13 (7) ◽  
pp. 89
Author(s):  
Prince Kwabena Osei ◽  
Collins Appiah ◽  
Alex Kojo Anderson
Keyword(s):  
Metabolic Syndrome ◽  
Intervention Study ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Diet Therapy ◽  
Team Approach ◽  
The Impact ◽  
Therapy Clinic ◽  
Dietetic Intervention

INTRODUCTION: The prevalence of metabolic syndrome (MetS) is rising globally. Dietetic intervention, as part of a multidisciplinary team approach, is increasingly being recommended for the effective management of patients with MetS. This study was designed to assess the impact of a dietetic intervention on MetS characteristics of patients attending the Diet Therapy Clinic at Tema General Hospital, Ghana. METHODOLOGY: A prospective pre-post single-arm intervention study was conducted among 168 participants who had been diagnosed with MetS and were referred to the Diet Therapy Clinic for dietetic intervention. Data on body mass index (BMI), waist circumference (WC), fasting blood glucose (FBG), high-density lipoprotein (HDL), serum triglyceride (TG), and blood pressure (BP) were collected at baseline and after three months of receiving a dietetic intervention. RESULTS: The MetS measures (BMI, WC, FBG, HDL and TG) of the patients improved at the end of the three months period (32.9 kg/m2 vs 31.7 kg/m2, p = 0.001; 101.2 cm vs 98.9 cm, p = 0.001; 11.0 mmol/L vs 7.7 mmol/L, p = 0.001; 1.1 mmol/L vs 1.2 mmol/L, p = 0.001; 2.0 mmol/L vs 1.9 mmol/L, p = 0.001 respectively). There were improvements in the mean systolic and diastolic BP values recorded after the three months (153 mmHg vs 131 mmHg, p = 0.001 and 98 mmHg vs 85 mmHg, p = 0.001 respectively). CONCLUSION: Dietetic intervention was found to have improved the MetS characteristics of patients.

scholarly journals Vascular wall status and its link with perivascular adipose tissue and other fat depots in young patients with abdominal obesity

2019 ◽  
Vol 16 (4) ◽  
pp. 80-86
Author(s):  
Ekaterina A Zheleznova ◽  
Juliya V Zhernakova ◽  
Olga A Pogorelova ◽  
Mariia I Tripoten ◽  
Nataliia V Blinova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Additional Risk Factor ◽  
Perivascular Adipose Tissue ◽  
Fat Depots ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To evaluate the common carotid artery (CCA) intima-media complex thickness (IMT) and the presence of atherosclerotic plaques (ASP) in young people with abdominal obesity who don’t have metabolic syndrome and those who have it, as well as a link between fat depots (perivascular, visceral, subcutaneous, epicardial) and CCA IMT. Materials and methods. The study included 145 people aged 18-45 years. They were divided into 3 groups: group 1 (n=18) - healthy volunteers (control group), group 2 (n=48) - patients with abdominal obesity and no more than one additional risk factor (metabolically healthy) and group 3 (n=79) - patients with metabolic syndrome. In persons included in the study the following parameters were measured: the height, weight, body mass index, waist circumference, fasting blood glucose, glucose tolerance, uric acid, lipid profile, insulin and the insulin resistance index (HOMA-IR). They also were given a 24-hour blood pressure monitoring, and an evaluation of CCA IMT, a presence of ASP in the carotid arteries and a maximum degree of internal carotid stenosis was performed using the duplex scan of brachiocephalic arteries. Computed tomography (Aquilion One Vision Edition, Toshiba, Japan) with determining subcutaneous, visceral, perivascular, epicardial fat was performed, and the ratio of subcutaneous to visceral fat was calculated. Results. Significant differences in mean CCA IMT were revealed only between persons of group 1 and group 3 (p=0.025), while the median of IMT were within normal ranges (group 1: 0.49 [0.46; 0.56]; group 2: 0.53 [0.49; 0.59]; group 3: 0.56 [0.52; 0.62]). Significant differences in a distribution of individuals with increased IMT between groups were also not revealed. However, the proportion of individuals with ASP was significantly higher in group 2 compared with group 1 (p

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