scholarly journals Nefrocalcinose e Necrose Gorda do Tecido Celular Subcutâneo

2014 ◽  
Vol 28 (1) ◽  
pp. 119 ◽  
Author(s):  
Cláudia Gomes ◽  
Luísa Lobo ◽  
António Siborro Azevedo ◽  
Carla Simão
Keyword(s):  
Chronic Kidney Disease ◽  
Subcutaneous Fat ◽  
Skin Lesions ◽  
Urinary Calcium ◽  
Self Healing ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Prompt Treatment ◽  
Infant Newborn ◽  
Serial Serum

<p>Subcutaneous fat necrosis of the newborn is an uncommon, transient and self-healing panniculits. This entity generally follows an uncomplicated course, however there are rare and important complications. The authors present a case of a newborn with subcutaneous fat necrosis complicated by hypercalcemia and nephrocalcinosis. The pathogenesis of hypercalcemia is not fully understood and the nephrocalcinosis can evolve to chronic kidney disease. Clinicians should be aware of subcutaneous fat necrosis as a possible risk<br />factor for hypercalcemia and patients should have serial serum and urinary calcium determinations for up to 6 months after the appearance of the skin lesions. The early diagnosis and prompt treatment of hypercalcemia are essential to prevent severe complications.<br /><strong>Keywords:</strong> Hypercalcemia; Fat Necrosis; Infant, Newborn; Nephrocalcinosis; Subcutaneous Fat. </p>

scholarly journals Subcutaneous fat necrosis of the newborn

2019 ◽  
Vol 12 (12) ◽  
pp. e231458 ◽  
Author(s):  
Niamh O' Brien ◽  
Breda Hayes
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Hand Preference ◽  
Skin Lesions ◽  
Term Infant ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Motor Delay ◽  
Full Resolution ◽  
Outcome Information

A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. At 13 months, she remains on low calcium formula, and has gross motor delay, central hypotonia and early hand preference. Review of 102 articles yielded 119 SFNN cases. Asphyxia was reported in 78%. Twenty-one per cent had hypoglycaemia. Twenty per cent underwent therapeutic hypothermia. Median onset of skin lesions was day 6 (range: 1–70), with a median duration of 62 days (range: 14–390). Hypercalcaemia developed in 53% (median onset day 28, range: 1–210). Fifty-two per cent of hypercalcaemia was asymptomatic. Outcome information was provided in 106/119 cases; 87% reported a full resolution. Persistent calcinosis was present in 6%. Babies treated with therapeutic hypothermia should be closely monitored for SFNN, and development of hypercalcaemia.

Repeated Occurrence of Skin Necrosis Twice Following Coumarin Intake and Subsequently During Decrease of Vitamin K Dependent Coagulation Factors Associated with Cholestasis

1982 ◽  
Vol 48 (03) ◽  
pp. 245-246 ◽  
Author(s):  
V Hofmann ◽  
P G Frick
Keyword(s):  
Skin Necrosis ◽  
Oral Anticoagulants ◽  
Subcutaneous Fat ◽  
Coagulation Factors ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Skin Changes ◽  
Factors Associated ◽  
Therapeutic Anticoagulation ◽  
Coumarin Necrosis

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.

Subcutaneous Fat Necrosis of the Newborn and Hyperferritinemia

2007 ◽  
Vol 24 (1) ◽  
pp. 93-93 ◽  
Author(s):  
LARISSA L. ZAULYANOV ◽  
SHARON E. JACOB ◽  
GEORGE W. ELGART ◽  
LAWRENCE SCHACHNER
Keyword(s):  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis
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