scholarly journals Macular Cystoid Edema Induced by Nab-Paclitaxel

2021 ◽  
Vol 34 (13) ◽  
Author(s):  
Sara Alves Pereira ◽  
Carolina Vale ◽  
Jorge Moreira ◽  
Filipa Sampaio
Keyword(s):  
Adverse Effect ◽  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Side Effect ◽  
Clinical Suspicion ◽  
Drug Discontinuation ◽  
Metastatic Pancreatic Adenocarcinoma ◽  
Rare Side Effect ◽  
The Right

A 61-year old male was referred to the Ophthalmology department because of decreased bilateral visual acuity. The patient had metastatic pancreatic adenocarcinoma and was being treated with gemcitabine+nab-paclitaxel. On examination, the patient presented best corrected visual acuities of 4/20 and 2/20 in the right and left eye, respectively. The optical coherence tomography revealed bilateral severe macular edema. Macular edema was considered secondary to nab-paclitaxel and the drug was discontinued. Three months after drug discontinuation, the patient presented best corrected visual acuities of 20/20 and 16/20 in the right and left eye, respectively, and normal fundoscopy. Macular edema is a very rare side effect of taxanes, and the etiopathology is still unknown. Edema is usually reversible upon discontinuation of the offending agent. Clinicians should be aware of this adverse effect of taxanes, and a high index of clinical suspicion is essential for diagnosis.

scholarly journals Type 3 Neovascularization Associated with Retinitis Pigmentosa

2017 ◽  
Vol 8 (1) ◽  
pp. 245-249 ◽  
Author(s):  
Jihene Sayadi ◽  
Alexandra Miere ◽  
Eric H. Souied ◽  
Salomon Y. Cohen
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Retinitis Pigmentosa ◽  
Macular Edema ◽  
Pigment Epithelium ◽  
High Flow ◽  
Type 3 Neovascularization ◽  
Capillary Plexus ◽  
The Right ◽  
Type 3

Purpose: To report a case of type 3 neovascular lesion in a patient with retinitis pigmentosa (RP) complicated by macular edema. Case Report: A 78-year-old man with a long follow-up for RP was referred for painless visual acuity decrease in the right eye. Best-corrected visual acuity was 20/125 in the right eye and 20/40 in the left. Fundus examination showed typical RP and macular edema in both eyes. In the right eye, spectral domain optical coherence tomography revealed a marked cystic macular edema associated with disruption of the Bruch membrane/retinal pigment epithelium complex overlying a pigmentary epithelium detachment, with a vascular structure which appeared to originate from the deep capillary plexus and to be connected with the subretinal pigment epithelium space. Optical coherence tomography angiography showed a high-flow vessel infiltrating the outer retinal layers in the deep capillary plexus segmentation, and a tuft-shaped, bright, high-flow network that seemed to be connected with the subretinal pigment epithelium space in the outer retinal layer segmentation. This presentation was consistent with an early type 3 neovascular lesion in the right eye. Conclusion: Type 3 neovascularization may be considered a possible complication of RP.

scholarly journals OPTICAL COHERENCE TOMOGRAPHY (OCT);

2014 ◽  
Vol 21 (06) ◽  
pp. 1264-1271
Author(s):  
Qamar Qamar Mehboob ◽  
M.H Qazi ◽  
Muhammad Arif
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Correlation Coefficient ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Research Centre ◽  
Optical Coherence ◽  
Department Of Ophthalmology ◽  
The Right

Objectives: To see the consequences of diabetic macular edema as assessed by optical coherence tomography (OCT) and visual acuity (V/A). Design: A prospective observational study. Patients were selected by simple random technique. Duration: Jan 2012 - Dec 2013. Material and Methods: A total of one hundred patients (200 eyes) of ages forty two to sixty three years with an average age of 51.04 ± 6.26 years of either sex were included. All these patients were examined in the outpatient department and were diagnosed as diabetic with macular edema and no opacity in refractive media. Their V/A was checked. OCT was performed in the Diagnostic & Research Centre, Department of Ophthalmology, Allied Hospital, Faisalabad. Results: Out of 200 eyes on OCT our findings were Diffuse Retinal Thickening in 199 eyes (99.5%), Cystoid Macular Edema in 119 eyes (59.5%), Subretinal Fluid in 48 eyes (24%), Epiretinal Membrane in 15 eyes(7.5%), Vitreomacular Traction in 11 eyes (5.5%) and Taut Posterior Hyaloid Membrane in 4 eyes(2%). The visual acuity on the right side was 0.29±0.19 and on left side it was 0.38±0.11. The macular thickness was 437.10±82.57 microns on the right side and 414.01±69.35 microns on the left side. The best-corrected visual acuity was significantly correlated with central foveal thickness. Our results showed, on the right side, a significant negative correlation (correlation coefficient: -0.355, p<0.01) between them. On the left side, a significant negative correlation (correlation coefficient: -0.362, p<0.01) was recorded.

Cystoid Macular Edema Secondary to Paclitaxel Therapy

2019 ◽  
Vol 2 ◽  
pp. 1 ◽  
Author(s):  
Anibal Martin Folgar ◽  
Jorge Oscar Zarate
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Fluorescein Angiography ◽  
Macular Edema ◽  
Cystoid Macular Edema ◽  
Metastatic Breast ◽  
Breast Adenocarcinoma ◽  
Optical Coherence ◽  
Ophthalmoscopic Examination

We present a 57-year-old referred reduced visual acuity who was in treatment with paclitaxel for developing metastatic breast adenocarcinoma. Ophthalmoscopic examination, optical coherence tomography, and autofluorescence show the cystoid macular edema, but fluorescein angiography is normal, without leakage of dye in the late times. The patient responds well 8 weeks after stopping antineoplastic. Paclitaxel can cause cystoid macular edema and lifting a recovery both anatomical and functional of the macula.

scholarly journals Foveal Exudative Macroaneurysm Treated with Intravitreal Ranibizumab

2015 ◽  
Vol 6 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Carlos Menezes ◽  
Rui Carvalho ◽  
Carla Teixeira ◽  
José Alberto Lemos ◽  
Rita Gonçalves ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Morphological Data ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Intravitreal Ranibizumab ◽  
Corrected Visual Acuity ◽  
Retinal Macroaneurysm ◽  
Best Corrected Visual Acuity

Purpose: We report a case of a foveal macroaneurysm with long-standing macular edema in a rare location, successfully treated with intravitreal ranibizumab. Methods: We report the case of a 52-year-old man with left eye long-term visual loss due to macular edema caused by a retinal macroaneurysm, localized about 400 μm from the center of the fovea, and its response to 6 monthly ranibizumab intravitreal injections. His best-corrected visual acuity and morphological data evaluated by optical coherence tomography and fluorescein angiography are presented. Results: His best-corrected visual acuity improved from 1/10 to 3/10 after the 3rd injection, and from 1/10 to 4/10 after the 6th one. The central retinal thickness was evaluated by optical coherence tomography and improved from 310 to 233 μm, with the resolution of both the associated serous detachments and the cystoid macular edema; an almost complete reabsorption of the hard exudates at the end of the treatment was also observed. The macroaneurysm lumen almost obliterated after the 3rd injection and completely collapsed at the end of treatment. Conclusions: Intravitreal ranibizumab may be effective in the treatment of long-standing macular edema associated with foveal macroaneurysms. To the best of our knowledge, this is the first report of a retinal macroaneurysm located so close to the foveal avascular zone.

scholarly journals ASSOCIATION OF THE EXTENT OF DIABETIC MACULAR EDEMA AS ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY WITH VISUAL ACUITY AND RETINAL OUTCOME VARIABLES

Retina ◽  
2009 ◽  
Vol 29 (3) ◽  
pp. 300-305 ◽  
Author(s):  
DAVID J. BROWNING ◽  
RAJENDRA S. APTE ◽  
SUSAN B. BRESSLER ◽  
KAKARLA V. CHALAM ◽  
RONALD P. DANIS ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence

scholarly journals Multifocal electroretinogram in diabetic macular edema; Correlation with visual acuity and optical coherence tomography

2015 ◽  
Vol 10 (2) ◽  
pp. 165 ◽  
Author(s):  
Hamid Riazi-Esfahani ◽  
Ebrahim Jafarzadehpur ◽  
Ali Mirzajani ◽  
Hossein Talebi ◽  
Abdulrahim Amini ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Multifocal Electroretinogram ◽  
Optical Coherence

scholarly journals Different Types of Maculopathy in Eyes after a High-Voltage Electrical Shock Injury

2019 ◽  
Vol 10 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Hye Rim Choe ◽  
Un Chul Park
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
High Voltage ◽  
Electrical Current ◽  
Final Visit ◽  
Electrical Injury ◽  
Electrical Shock ◽  
Retinal Atrophy ◽  
Different Types ◽  
The Right

Background: We report a case of different types of maculopathy in eyes after a high-voltage electrical shock injury. Case Report: A 43-year-old male suffered high-voltage electrical injury through his left arm. He underwent cataract surgery in both eyes 3 months after the injury, but there was no vision improvement. Ocular examination, including spectral domain optical coherence tomography, revealed diffuse retinal atrophy in the left eye which did not change until the final visit. In the right eye, an impending macular hole was observed but regressed spontaneously 9 months after the injury, and the visual acuity improved to 20/32 at the final visit. Conclusion: Two different types of maculopathy can occur in each eye after high-voltage electrical shock injury, and this might be due to asymmetric pathogenesis of the eyes according to the proximity to the route of electrical current.

scholarly journals Absent Foveal Pit, Also Known as Fovea Plana, in a Child without Associated Ocular or Systemic Findings

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Laura Hernandez-Moreno ◽  
Natacha Moreno Perdomo ◽  
Tomas S. Aleman ◽  
Karthikeyan Baskaran ◽  
Antonio Filipe Macedo
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Caucasian Male ◽  
Corrected Visual Acuity ◽  
Abnormal Structure ◽  
Ophthalmologic Examination ◽  
Foveal Hypoplasia ◽  
Systemic Manifestations ◽  
The Right ◽  
Best Corrected Visual Acuity

The purpose of this report is to describe a case of bilateral foveal hypoplasia in the absence of other ophthalmological or systemic manifestations. We characterize the case of a 9-year-old Caucasian male who underwent full ophthalmologic examination, including functional measures of vision and structural measurements of the eye. Best corrected visual acuity was 0.50 logMAR in the right eye and 0.40 logMAR in the left eye. Ophthalmoscopy revealed a lack of foveal reflex that was further investigated. Optical coherence tomography (OCT) confirmed the absence of foveal depression (pit). OCT images demonstrated the abnormal structure of retina in a region in which we expected a fovea; these findings were decisive to determine the cause of reduced acuity in the child.

Large choroidal excavation in pachychoroid disease: A case report

2019 ◽  
pp. 112067211989242 ◽  
Author(s):  
Pierluigi Iacono ◽  
Maurizio Battaglia Parodi ◽  
Sandro Saviano ◽  
Mariacristina Parravano ◽  
Monica Varano
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Indocyanine Green ◽  
Choroidal Neovascularization ◽  
Indocyanine Green Angiography ◽  
Fundus Examination ◽  
Corrected Visual Acuity ◽  
Focal Choroidal Excavation ◽  
The Right ◽  
Best Corrected Visual Acuity

Purpose: To report the morphological and clinical features of a case of pachychoroid disease with focal choroidal excavation and large choroidal excavation complicated by choroidal neovascularization. Methods: The patient underwent a complete ophthalmologic examination including best-corrected visual acuity assessment, anterior segment and dilated fundus examination, fluorescein and indocyanine green angiography, and spectral-domain optical coherence tomography. Results: During the previous follow-up, the 57-year-old man received a diagnosis of central serous chorioretinopathy in the right eye with a late appearance of a choroidal neovascularization. The best-corrected visual acuity was 20/125 and 20/20 in the right and left eye, respectively. Dilated fundus examination, fluorescein angiography, and indocyanine green angiography confirmed a large subretinal fibrosis corresponding to the evolution of the choroidal neovascularization in the right eye. Spectral-domain optical coherence tomography clearly demonstrated in the right eye a large choroidal excavation below the fibrotic neovascular lesion with multiple hyperreflective foci inside the cavity, and in the left eye, a conforming focal choroidal excavation, bowl-shape type, associated with increased choroidal thickness with pachyvessels. Conclusion: Large choroidal excavation has been rarely reported. Although the pathogenetic mechanisms leading to the formation of large choroidal excavation are still only hypotheses, a combination of primary degenerative inflammatory factors sustaining the focal choroidal excavation formation and disruptive process of the choroidal neovascularization could be retained responsible for the large choroidal excavation.

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