scholarly journals Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

2019 ◽  
Vol 32 (11) ◽  
pp. 714
Author(s):  
Joana Cosme ◽  
Amélia Spínola ◽  
Manuel Branco Ferreira ◽  
Manuel Pereira Barbosa
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Hereditary Angioedema ◽  
Enzyme Inhibitor ◽  
Incidental Finding ◽  
Admission Rate ◽  
Converting Enzyme ◽  
Drug Induced ◽  
Converting Enzyme Inhibitor ◽  
The Mean

Introduction: Hospitalizations due to angioedema are important especially in debilitating or life-threatening situations. The aim of this study was to evaluate the frequency and etiology of angioedema without urticaria in hospital admissions.Material and Methods: The admissions between 2009 and 2013 in Centro Hospitalar Lisboa Norte with a diagnosis grouped under the ICD9 codes of angioedema were retrospectively analysed. The episodes of angioedema with urticaria were excluded. The admissions were categorized into 2 groups: A — hospitalizations motivated by the angioedema; B — hospitalizations in which the angioedema was an incidental finding.Results: There were 169 hospitalizations (52% females, 96% adults, mean age 52 ± 20.8 years), distributed by 23 hospital departments, 51% in the Immunoallergology department. The mean annual angioedema admission rate was 72/100 000. In 68% of the cases, angioedema was the cause for the admission; in 32% an incidental finding. In 38% there was upper airway involvement. The etiologies were: hereditary angioedema in 24%, angiotensin converting enzyme inhibitor induced angioedema in 31%, idiopathic angioedema in 21%, thrombolysis induced angioedema in 13%, nonsteroidal anti-inflammatory drug-induced angioedema in 5%.Discussion: The main etiology was angiotensin converting enzyme inhibitor angioedema, followed by hereditary angioedema and thrombolysis induced angioedema, and these findings concur with the international literature.Conclusion: The mean annual angioedema admission rate was 72/100 000 and there was airway involvement in 38% of hospitalizations.

Does Angiotensin-Converting Enzyme Inhibitor Use Exacerbate Hereditary Angioedema?

2013 ◽  
Vol 45 (4) ◽  
pp. 602-608
Author(s):  
Getaw Worku Hassen ◽  
Ting Jia Tu ◽  
Daniel Hsiang Wei ◽  
Albert Hwang ◽  
Romus Lamothe ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Hereditary Angioedema ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor

scholarly journals Angiotensin-converting Enzyme Inhibitor-induced Angioedema and Hereditary Angioedema: A Comparison Study of Attack Severity

2015 ◽  
Vol 54 (20) ◽  
pp. 2583-2588 ◽  
Author(s):  
Nicolas Javaud ◽  
Stéphane Charpentier ◽  
Frédéric Lapostolle ◽  
Hakim Lekouara ◽  
Marouane Boubaya ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Hereditary Angioedema ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Comparison Study ◽  
Converting Enzyme Inhibitor

scholarly journals PENGARUH DEGRADASI ENZIM PROTEOLITIK TERHADAP AKTIVITAS ANGIOTENSIN CONVERTING ENZYME INHIBITOR BEKASAM DENGAN Lactobacillus plantarum B1765 (The Effect of Degradation of Proteolitic Enzyme on Angiotensin Converting Enzyme Inhibitor Activity of Bekasam with Lactobacillus plantarum B1765)

2016 ◽  
Vol 36 (02) ◽  
pp. 170 ◽  
Author(s):  
Prima Retno Wikandari ◽  
Lenny Yuanita
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Lactobacillus Plantarum ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor ◽  
Enzyme Degradation ◽  
Before And After ◽  
The Mean ◽  
The Stability

This research studied the effect of digestive enzyme degradation on the Angiotensin Converting Enzyme Inhibitor (ACEI) activity and the stability of bekasam peptide and ACEI activity. Water extract of bekasam was subjected to pepsin and trypsin. The stability of peptide was measured from the changes of peptide concentration before and after treatment by those enzymes. The stability of ACEI activity was measured by hypuric acid liberated from Hip-His-Leu as ACE substrate and determined by spectrophotometer. The results showed that proteolytic enzyme degradation did not affect the concentration of peptide (p>0,05) and the mean concentration 36.72. It was closely related with the ACEI activity that did not change significantly before and after digestion by pepsin and trypsin (p>0,05) and the mean ACEI activity was 70.73. It showed that ACEI activity of bekasam did not change by the degradation of digestive enzyme.Keywords: bekasam, fermented fish, peptides, ACEI activityABSTRAKPenelitian ini bertujuan untuk mengkaji pengaruh degradasi enzim pencernaan proteolitik terhadap stabilitas peptida dan aktivitas Angiotensin Converting Enzyme Inhibitor (ACEI) bekasam yang difermentasi dengan kultur starter Lactobacillus plantarum B1765. Terhadap ekstrak bekasam diberi perlakuan enzim proteolitik pepsin dan tripsin. Pengujian stabilitas peptida diukur dengan ada tidaknya perubahan jumlah peptida setelah perlakuan enzim menggunakan metode formol, sedangkan aktivitas ACEI dilakukan dengan mengetahui jumlah asam hipurat dari substrat Hip-His-Leu yang dibebaskan oleh ACE diukur dengan spektrofotometer. Hasil pengujian menunjukkan perlakuan enzim proteolitik tidak berpengaruh pada konsentrasi peptida dengan p>0,05 dengan nilai rata-rata konsentrasi peptida sebesar 36,72. Hal ini berkorelasi dengan aktivitas ACEI yang juga menunjukkan tidak ada pengaruh antara perlakuan sebelum dan setelah degradasi enzim (p>0,05) dengan rata-rata aktivitas ACEI sebesar 70,73. Hasil penelitian ini menunjukkan bahwa aktivitas ACEI bekasam tidak berubah jika mengalami degradasi enzim pencernaan.Kata kunci: Bekasam, fermentasi ikan, peptida, ACE inhibitor

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