scholarly journals Enhanced plasticity of mature granule cells reduces survival of newborn neurons in the adult mouse hippocampus

2016 ◽  
Author(s):  
Felix Kleine Borgmann ◽  
Johannes Gräff ◽  
Isabelle Mansuy ◽  
Nicolas Toni ◽  
Sebastian Jessberger
Keyword(s):  
Adult Mouse ◽  
Granule Cells ◽  
Mouse Hippocampus ◽  
Newborn Neurons

scholarly journals Live imaging of neurogenesis in the adult mouse hippocampus

Science ◽  
2018 ◽  
Vol 359 (6376) ◽  
pp. 658-662 ◽  
Author(s):  
Gregor-Alexander Pilz ◽  
Sara Bottes ◽  
Marion Betizeau ◽  
David J. Jörg ◽  
Stefano Carta ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Hippocampal Neurogenesis ◽  
Cell Fates ◽  
Comprehensive Description ◽  
Mouse Hippocampus ◽  
Asymmetric Divisions ◽  
Stem And Progenitor Cells ◽  
Newborn Neurons ◽  
Insight Into

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis.

scholarly journals Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus

2016 ◽  
Vol 36 (28) ◽  
pp. 7407-7414 ◽  
Author(s):  
G.-A. Pilz ◽  
S. Carta ◽  
A. Stauble ◽  
A. Ayaz ◽  
S. Jessberger ◽  
...  
Keyword(s):  
Functional Imaging ◽  
Adult Mouse ◽  
Granule Cells ◽  
Dentate Granule Cells ◽  
Mouse Hippocampus

Morphological analysis of axons of newly generated granule cells in adult mouse hippocampus

2007 ◽  
Vol 58 ◽  
pp. S209
Author(s):  
Yoko Ide ◽  
Fumino Fujiyama ◽  
Keiko Furuta ◽  
Nobuaki Tamamaki ◽  
Takeshi Kaneko ◽  
...  
Keyword(s):  
Morphological Analysis ◽  
Adult Mouse ◽  
Granule Cells ◽  
Mouse Hippocampus

Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus

2017 ◽  
Vol 31 (7) ◽  
pp. 2839-2853 ◽  
Author(s):  
Sandeep Kumar Agnihotri ◽  
Ruifang Shen ◽  
Jihong Li ◽  
Xu Gao ◽  
Hansruedi Büeler
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
Mouse Hippocampus ◽  
Newborn Neurons
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