scholarly journals Traitements multiples par l'acéturate de diminazène chez les bovins : effets sur l'infectivité d'une souche chimiorésistante de Trypanosoma congolense et sur sa transmissibilité par Glossina morsitans centralis

1998 ◽  
Vol 51 (3) ◽  
pp. 211-218
Author(s):  
A. Diack ◽  
S.K. Moloo ◽  
A.S. Peregrine
Keyword(s):  
Trypanosoma Congolense ◽  
Glossina Morsitans ◽  
Poids Corporel ◽  
Glossina Morsitans Centralis

Six bovins de race Boran ont été infectés par la souche chimiorésistante IL 3338 de Trypanosoma congolense. Au premier pic de parasitémie, 200 Glossina morsitans centralis ténérales organisées en plusieurs groupes ont été nourries sur chaque animal, juste avant leur traitement à l'acéturate de diminazène à la dose de 3,5 mg/kg de poids corporel (p.c.). Les animaux ont ensuite étaient suivis par prélèvement sanguin trois fois par semaine et ont été traitées comme précédemment chaque fois que l'hématocrite baissait dans trois prélèvements consécutifs, pour au moins un des animaux. Après huit traitements à approximativement deux semaines d'intervalle, la longueur moyenne de la période prépatente après chaque traitement n'a pas augmenté, restant à 7,8 +- 1,1 jours. La valeur moyenne de l'hématocrite est descendue de 33,2 +- 0,6 % lors du premier traitement, à 23,7 +- 2,6 % entre les huitième et neuvième traitements. En conséquence, à la suite du huitième traitement, l'acéturate de diminazène a été administré comme précédemment, mais à la dose de 7,0 mg/kg p.c. Résultant de l'augmentation de la dose, la valeur moyenne de l'hématocrite entre deux traitements est montée de 25,4 +- 2,4 % sitôt après le premier traitement à 32,9 +- 1,7 pour les deux mois qui ont suivi le cinquième traitement.

Susceptibility of African buffalo and Boran cattle to Trypanosoma congolense transmitted by Glossina morsitans centralis

1990 ◽  
Vol 35 (3) ◽  
pp. 219-231 ◽  
Author(s):  
J.G. Grootenhuis ◽  
R.H. Dwinger ◽  
R.B. Dolan ◽  
S.K. Moloo ◽  
Max Murray
Keyword(s):  
Trypanosoma Congolense ◽  
African Buffalo ◽  
Glossina Morsitans ◽  
Glossina Morsitans Centralis

scholarly journals Trypanosoma congolense in the Microvasculature of the Pituitary Gland of Experimentally Infected Boran Cattle (Bos indicus)

1993 ◽  
Vol 30 (5) ◽  
pp. 401-409 ◽  
Author(s):  
G. Abebe ◽  
M. K. Shaw ◽  
R. M. Eley
Keyword(s):  
Electron Microscopy ◽  
Extracellular Matrix ◽  
Structural Changes ◽  
Bos Indicus ◽  
Light And Electron Microscopy ◽  
Trypanosoma Congolense ◽  
Glossina Morsitans ◽  
Glossina Morsitans Centralis ◽  
Pituitary Glands ◽  
Female Control

The pituitary glands of seven Boran cattle ( Bos indicus), five infected with a clone of Trypanosoma congolense IL 1180 (ILNat 3.1) transmitted by Glossina morsitans centralis and two uninfected controls, were examined by light and electron microscopy 43 (experiment 2) or 56 (experiment 1) days after fly challenge. The three cattle used in the first experiment included a 15-month-old female (No. 1), a 24–month-old female (No. 2), and a 21–month-old male (No. 3) as a control. In the second experiment, four cattle were used: two females (Nos. 4, 5) and one male (No. 6), all between 15 and 24 months of age, and one female control (No. 7) of similar age. In all the infected animals, dilation of both the sinusoids and microvasculature was apparent, as was an increase in the thickness of the extracellular matrix between the pituitary lobules. Trypanosomes were found in the microvasculature of the adenohypophysis and neurohypophysis in all the infected animals. Focal degenerative changes were seen in the adenohypophyseal section of glands from the infected animals euthanatized 56 days post-infection. These degenerative structural changes were confined to the somatotrophs cells. The possible role that trypanosomes in the microvasculature may play in inducing pituitary damage and dysfunction is discussed.

Comparative study on Rickettsia-like organisms in the midgut epithelial cells of differentGlossinaspecies

Parasitology ◽  
1991 ◽  
Vol 102 (2) ◽  
pp. 193-199 ◽  
Author(s):  
M. K. Shaw ◽  
S. K. Moloo
Keyword(s):  
Electron Microscopy ◽  
Epithelial Cells ◽  
Comparative Study ◽  
Trypanosoma Congolense ◽  
Infection Rates ◽  
Cell Cytoplasm ◽  
Glossina Morsitans ◽  
Host Cell Cytoplasm ◽  
Glossina Morsitans Centralis ◽  
Micro Organisms

SUMMARYThe midgut epithelium ofGlossina morsitans centralis, G. austeni, G. pallidipes, G. palpalis palpalis, G. p. gambiensis, G. fuscipes fuscipes, G. tachinoidesandG. brevipalpisfrom ILRAD-bred colonies was examined, by electron microscopy, for the presence and distribution of Rickettsia-like organisms (RLOs). RLOs were present in the midgut epithelial cells of all non-teneral tsetse. InG. m. centralis, G. pallidipesand, to a much lesser extent,G. brevipalpis, RLOs were numerous and were present in all the specimens examined. RLOs were present in fewer numbers in the epithelial cells of tenerals of these three tsetse species. In contrast, RLOs occurred in very much lower numbers within the midgut cells of nonteneralG. austeni, G. p. palpalis, G. p. gambiensis, G. f. fuscipesandG. tachinoides; were not seen in every specimen, and were rarely observed in the midgut cells of teneral tsetse. The RLOs were typical rod-shaped bacteria with an inner and outer membrane, which occurred free within the host cell cytoplasm and appeared to cause no obvious pathology. The micro-organisms divided by binary fission and at least two distinct morphological forms plus a range of intermediate forms were seen in the midgut cells. A comparison of the presence and numbers of RLOs within the midgut cells and the midgut infection rates of bothTrypanosoma congolenseandT. b. brucei, both betweenGlossinaspecies and also within the same stock of tsetse, clearly indicates that the ability of trypanosomes to establish and develop to mature infections is unlikely to be correlated solely with the presence of RLOs within the tsetse midgut.

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