scholarly journals Neural Stem Cells and Induced Neurons for Nerve Injury Repair

2015 ◽  
Vol 01 (01) ◽  
Author(s):  
Yi Chao Hsu ◽  
Su Liang Chen ◽  
Tai Yu Hsu ◽  
Ing Ming Chiu
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Nerve Injury ◽  
Injury Repair ◽  
Induced Neurons

scholarly journals MiR-7 inhibited peripheral nerve injury repair by affecting neural stem cells migration and proliferation through cdc42

2018 ◽  
Vol 14 ◽  
pp. 174480691876679 ◽  
Author(s):  
Nan Zhou ◽  
Shuang Hao ◽  
Zongqiang Huang ◽  
Weiwei Wang ◽  
Penghui Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Neural Stem Cells ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Injury Repair

Neural Stem Cells Enhance Nerve Regeneration after Sciatic Nerve Injury in Rats

2012 ◽  
Vol 46 (2) ◽  
pp. 265-274 ◽  
Author(s):  
Lin Xu ◽  
Shuai Zhou ◽  
Guo-Ying Feng ◽  
Lu-Ping Zhang ◽  
Dong-Mei Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Sciatic Nerve ◽  
Neural Stem Cells ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Sciatic Nerve Injury

Direct neuronal differentiation of neural stem cells for spinal cord injury repair

Stem Cells ◽  
2021 ◽  
Vol 39 (8) ◽  
pp. 1025-1032 ◽  
Author(s):  
Weiwei Xue ◽  
Caixia Fan ◽  
Bing Chen ◽  
Yannan Zhao ◽  
Zhifeng Xiao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Injury Repair ◽  
Cord Injury

Training Neural Stem Cells on Functional Collagen Scaffolds for Severe Spinal Cord Injury Repair

2016 ◽  
Vol 26 (32) ◽  
pp. 5835-5847 ◽  
Author(s):  
Xing Li ◽  
Sumei Liu ◽  
Yannan Zhao ◽  
Jiayin Li ◽  
Wenyong Ding ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Collagen Scaffolds ◽  
Injury Repair ◽  
Cord Injury

Compound K induces neurogenesis of neural stem cells in thrombin induced nerve injury through LXRα signaling in mice

2020 ◽  
Vol 729 ◽  
pp. 135007 ◽  
Author(s):  
Li Zhou ◽  
Fan Yang ◽  
Jie-wen Yin ◽  
Xi Gu ◽  
Yue Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Nerve Injury ◽  
Compound K

Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair

2018 ◽  
Vol 6 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Xing Li ◽  
Jianwu Dai
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Collagen Scaffolds ◽  
Neural Repair ◽  
Injury Repair ◽  
Cord Injury ◽  
Cell Source ◽  
Endogenous Neural Stem Cells

Severe spinal cord injury (SCI) induces massive proliferation of spinal cord neural stem cells (NSCs), which are considered a promising cell source for therapeutic neural repair.

scholarly journals Transplantation of Wnt4-Modified Neural Stem Cells Mediate M2 Polarization to Promote Spinal Cord Injury Repair

2021 ◽  
Author(s):  
Xiang Li ◽  
Lingli Long ◽  
Yue Hu ◽  
Wenwu Zhang ◽  
Fangling Zhong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Signal Pathway ◽  
Inflammatory Microenvironment ◽  
Injury Repair ◽  
M2 Polarization ◽  
M1 Polarization ◽  
Cord Injury

Abstract Background: Neural stem cells (NSCs) transplantation has been considered as a potential strategy to reconnect the neural circuit after spinal cord injury (SCI) but the therapeutic effect was still unsatisfied because of the poor inflammatory microenvironment. Previous study reported that neuroprotection and inflammatory immunomodulation were considered to be most important mechanism of NSCs transplantation. In addition, Wnt4 has been considered to be neurogenesis and anti-inflammatory so that it would be an essential assistant agent for NSCs transplantation.Results: We report the first piece of evidence to confirm the interaction between Wnt4-modified NSCs and macrophages using NSCs- macrophages co-cultured system. Wnt4-modified NSCs induce M2 polarization and inhibit M1 polarization of macrophages through suppress TLR4/NF-κB signal pathway; furthermore, M2 cells promote neuronal differentiation of NSCs through MAPK/JNK signal pathway. In vivo, transplantation of Wnt4-modified NSCs improve inflammatory microenvironment through induce M2 polarization and inhibit M1 polarization of macrophages to promote axonal regeneration and tissue repair.Conclusion: The current study indicated that transplantation of Wnt4-modified NSCs mediate M2 polarization of macrophages to promote spinal cord injury repair. Our novel findings would provide more insight of SCI and help with identification of novel treatment strategy.

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