scholarly journals Effect of alpha-lipoic acid on asymmetric dimethylarginine and disability in multiple sclerosis patients: A randomized clinical trial

10.19082/4899 ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 4899-4905 ◽  
Author(s):  
Mohammad Khalili ◽  
Madjid Soltani ◽  
Shirin Amiri Moghadam ◽  
Parvin Dehghan ◽  
Amirreza Azimi ◽  
...  
2018 ◽  
Vol 33 (6) ◽  
pp. 1255-1262 ◽  
Author(s):  
Natália Guimarães Barbosa ◽  
Amanda Katarinny Goes Gonzaga ◽  
Luzia Leiros de Sena Fernandes ◽  
Aldilane Gonçalves da Fonseca ◽  
Salomão Israel Monteiro Lourenço Queiroz ◽  
...  

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Shima Mehrabadi ◽  
Elham Zahedi

Context: Numerous studies have indicated that vitamin D can modulate the immune system and plays an important role in regulating immune cells’ functions. Some clinical studies have assessed the effect of vitamin D supplementation on cytokine markers in multiple sclerosis (MS) as a disease in which the immune system’s function is disrupted. Evidence Acquisition: This study was designed to assess randomized clinical trial studies evaluating the overall effect of vitamin D on the levels of IL-10, IL-17, and IFN-γ in MS patients. Methods: We searched PubMed and Scopus online databases up to November 2020 for relevant randomized clinical trial studies by using certain keywords. Eight studies from 273 articles, with a total sample of 443 participants, were considered Results: The meta-analysis indicated that vitamin D consumption did not significantly change the levels of IL-10 (WMD : -174.56, 95% CI: -373.10 to 23.98), IL-17 (WMD : -0.11, 95% CI: -0.54.10 to 0.33), or IFN-γ (WMD : 61.47, 95% CI: 43.96 to 78.98) in MS patients. Conclusions: Further clinical trials are warranted to evaluate the effects of vitamin D supplement on IL-10 and IL-17, and INFγ levels in MS patients.


2015 ◽  
Vol 19 (3) ◽  
pp. 138-143 ◽  
Author(s):  
Meisam Sanoobar ◽  
Parvin Dehghan ◽  
Mohammad Khalili ◽  
Amirreza Azimi ◽  
Fatemeh Seifar

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