scholarly journals Effects of Fenton Reaction on Human Serum Albumin: An In Vitro Study

10.19082/2970 ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2970-2976 ◽  
Author(s):  
Meysam Khosravifarsani ◽  
Ali Shabestani Monfared ◽  
Mahdi Pouramir ◽  
Ebrahim Zabihi
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fenton Reaction ◽  
In Vitro Study ◽  
Vitro Study

In vitro study on the interaction of methoxyflurane with human serum albumin: Phenotypic characterization

2013 ◽  
Vol 153 ◽  
pp. 107-113 ◽  
Author(s):  
Aning Xing ◽  
Bin Jia ◽  
Xuan Li ◽  
Zhaodi Zhang ◽  
Guangying Gu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Vitro Study ◽  
Vitro Study ◽  
Phenotypic Characterization

ChemInform Abstract: SYNTHESIS AND IN VITRO STUDY OF THYMIDINE AND HYPOXANTHINE CONJUGATES WITH MICROAGGREGATES OF HUMAN SERUM ALBUMIN

1980 ◽  
Vol 11 (39) ◽  
Author(s):  
N. A. BRUSENTSOV ◽  
V. M. BUKHMAN ◽  
G. A. BELITSKII ◽  
E. G. SLAVINA ◽  
I. L. LEIPUNSKAYA ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Vitro Study ◽  
Vitro Study

In vitro study on the interaction between thiophanate methyl and human serum albumin

2009 ◽  
Vol 94 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Jinhua Li ◽  
Xiaoyan Liu ◽  
Cuiling Ren ◽  
Jiazhong Li ◽  
Fenling Sheng ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Vitro Study ◽  
Vitro Study ◽  
Thiophanate Methyl

scholarly journals Impact of high glucose concentration on aspirin-induced acetylation of human serum albumin: An in vitro study

2014 ◽  
Vol 3 ◽  
pp. 100-113 ◽  
Author(s):  
Francesco Finamore ◽  
Feliciano Priego-Capote ◽  
Florent Gluck ◽  
Anne Zufferey ◽  
Pierre Fontana ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
High Glucose ◽  
Glucose Concentration ◽  
In Vitro Study ◽  
Vitro Study ◽  
High Glucose Concentration

In vitro study on the interaction of Mn(II)-DiAmsar with human serum albumin (HSA) and bovine serum albumin (BSA) by spectroscopic and molecular docking methods

2014 ◽  
Vol 12 (4) ◽  
pp. 715-725 ◽  
Author(s):  
Zari Hooshyar ◽  
Ghasem Rezanejade Bardajee ◽  
Pegah Shafagh ◽  
Samira Ghiasvand ◽  
Mohaddeseh Khanjari ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Human Serum Albumin ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Bovine Serum ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Physicochemical characterization of carbamylated human serum albumin: an in vitro study

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 36508-36516
Author(s):  
Asim Badar ◽  
Zarina Arif ◽  
Shireen Naaz Islam ◽  
Khursheed Alam
Keyword(s):  
Amino Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Physicochemical Characterization ◽  
In Vitro Study ◽  
Terminal Amino ◽  
Carbamyl Amino Acids

Carbamylation is an ubiquitous process in which cyanate (OCN−) reacts with the N-terminal amino or ε-amino moiety and generates α-carbamyl amino acids and ε-carbamyl-lysine (homocitrulline).

scholarly journals Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 409 ◽  
Author(s):  
Violetta Mohos ◽  
Eszter Fliszár-Nyúl ◽  
Beáta Lemli ◽  
Balázs Zoltán Zsidó ◽  
Csaba Hetényi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Vitro Study ◽  
Limited Information ◽  
Cytochrome P450 Enzymes ◽  
Flavonoid Aglycones ◽  
Pharmacokinetic Interactions

Flavonoids are abundant polyphenols in nature. They are extensively biotransformed in enterocytes and hepatocytes, where conjugated (methyl, sulfate, and glucuronide) metabolites are formed. However, bacterial microflora in the human intestines also metabolize flavonoids, resulting in the production of smaller phenolic fragments (e.g., hydroxybenzoic, hydroxyacetic and hydroxycinnamic acids, and hydroxybenzenes). Despite the fact that several colonic metabolites appear in the circulation at high concentrations, we have only limited information regarding their pharmacodynamic effects and pharmacokinetic interactions. Therefore, in this in vitro study, we investigated the interactions of 24 microbial flavonoid metabolites with human serum albumin and cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes. Our results demonstrated that some metabolites (e.g., 2,4-dihydroxyacetophenone, pyrogallol, O-desmethylangolensin, and 2-hydroxy-4-methoxybenzoic acid) form stable complexes with albumin. However, the compounds tested did not considerably displace Site I and II marker drugs from albumin. All CYP isoforms examined were significantly inhibited by O-desmethylangolensin; nevertheless, only its effect on CYP2C9 seems to be relevant. Furthermore, resorcinol and phloroglucinol showed strong inhibitory effects on CYP3A4. Our results demonstrate that, besides flavonoid aglycones and their conjugated derivatives, some colonic metabolites are also able to interact with proteins involved in the pharmacokinetics of drugs.

Nof2206Probing the interaction of memantine, an important Alzheimer's drug, with human serum albumin: In silico and In vitro approach

2021 ◽  
pp. 116888
Author(s):  
Fahad A. Alhumaydhi ◽  
Mohammad Abdullah Aljasir ◽  
Abdullah S.M. Aljohani ◽  
Suliman A. Alsagaby ◽  
Ameen S.S. Alwashmi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Silico
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