scholarly journals Herbal Medicines for the Management of Irritable Bowel Syndrome: A Systematic Review

10.19082/2719 ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 2719-2725 ◽  
Author(s):  
Hamid Reza Bahrami ◽  
Shokouhsadat Hamedi ◽  
Roshanak Salari ◽  
Mohammadreza Noras
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Herbal Medicines ◽  
Irritable Bowel

Western Herbal Medicines in the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

2019 ◽  
Vol 6 ◽  
pp. S104 ◽  
Author(s):  
Jason Hawrelak ◽  
Hans Wohlmuth ◽  
Martina Pattinson ◽  
Stephen Myers ◽  
Joshua Goldenberg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Herbal Medicines ◽  
Irritable Bowel

Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis

2020 ◽  
Vol 48 ◽  
pp. 102233 ◽  
Author(s):  
Jason A. Hawrelak ◽  
Hans Wohlmuth ◽  
Martina Pattinson ◽  
Stephen P. Myers ◽  
Joshua Z. Goldenberg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Herbal Medicines ◽  
Irritable Bowel

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

Sign in / Sign up

Export Citation Format

Share Document