scholarly journals The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial

10.19082/2602 ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 2602-2606 ◽  
Author(s):  
Mohammad Hossein Jarahzadeh ◽  
Sina Taghizadeh Harati ◽  
Hamideh Babaeizadeh ◽  
Elahe Yasaei ◽  
Farshid Rahimi Bashar
Keyword(s):  
Clinical Trial ◽  
General Anesthesia ◽  
Magnesium Sulfate ◽  
Randomized Clinical Trial ◽  
Abdominal Hysterectomy ◽  
Double Blind ◽  
Intravenous Magnesium ◽  
Reduction Of Pain

scholarly journals The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

2021 ◽  
Vol 31 (2) ◽  
Author(s):  
Fatemeh Jahanian ◽  
Iraj Goli Khatir ◽  
Hamed Amini Ahidashti ◽  
Sepideh Amirifard
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Magnesium Sulfate ◽  
Magnesium Sulphate ◽  
Intervention Group ◽  
Control Group ◽  
Double Blind ◽  
Intravenous Magnesium ◽  
Acute Exacerbations ◽  
And Control

BACKGROUND፡ Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are serious complications that often require immediate intervention in an emergency department (ED). The aim of this study was to investigate the effect of intravenous magnesium sulphate as an adjuvant in the treatment of AECOPD in the ED.METHODS: In a double-blind, randomized clinical trial, a total of 60 patients with AECOPD presenting to the ED of Imam Khomeini Hospital in Sari, Iran, were included. The study was conducted between September 2016 and February 2018. Eligible patients were randomly allocated into two groups of intervention and control. Patients in the intervention and control groups received intravenous infusion of magnesium sulfate (2 gr) or normal saline over 30 minutes, respectively. For all patients, Borgdyspnea score, forced expiratory volume in one second (FEV1) result and clinical variables of interest were evaluated before the beginning of the intervention, and also 45 minutes and 6 hours after the commencement of intervention.RESULTS: Regardless of time of evaluation, pulse rate (PR), respiratory rate (RR) and Borg score in intervention group was lower than control group. Also, FEV1 and SPO2 were greater in intervention group compared to control group. However, these differences were not statistically significant (between-subject differences or group effect) (p<0.001). The trends of FEV1, SPO2, PR, RR and Borg score were similar between two groups of study (no interaction effect; P>0.05).CONCLUSION: According to the results of this study, it seems that using intravenous magnesium sulfate has no significant effect on SPO2, FEV1, RR, and PR of patients with AECOPD who presented to ED.

scholarly journals Effects of Single Low Dose of Dexamethasone before Noncardiac and Nonneurologic Surgery and General Anesthesia on Postoperative Cognitive Dysfunction—A Phase III Double Blind, Randomized Clinical Trial

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0152308 ◽  
Author(s):  
Livia Stocco Sanches Valentin ◽  
Valeria Fontenelle Angelim Pereira ◽  
Ricardo S. Pietrobon ◽  
Andre P. Schmidt ◽  
Jean P. Oses ◽  
...  
Keyword(s):  
Clinical Trial ◽  
General Anesthesia ◽  
Randomized Clinical Trial ◽  
Cognitive Dysfunction ◽  
Low Dose ◽  
Postoperative Cognitive Dysfunction ◽  
Phase Iii ◽  
Double Blind

scholarly journals PERBANDINGAN EFEKTIFITAS DEXAMETHASON DAN LIDOKAIN DALAM MENCEGAH NYERI TENGGOROKAN SETELAH INTUBASI ENDOTRAKEAL PADA ANESTESI UMUM

2019 ◽  
Vol 1 (2) ◽  
pp. 22-30
Author(s):  
John Frans Sitepu
Keyword(s):  
Clinical Trial ◽  
General Anesthesia ◽  
Randomized Clinical Trial ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Elective Surgery ◽  
Double Blind ◽  
Lidocaine Group ◽  
Throat Pain ◽  
Surgical Pain

Throat pain is a complication that is often found in patients with general anesthesia who use endotracheal intubation that is difficult to control even though surgical pain is well controlled using systemic analgesia. The purpose of this study was to see a comparison of the effectiveness of treatment in the prevention of throat pain in general anesthesia. This study used a double blind randomized clinical trial method conducted at three sites. The sample of this study was all patients who underwent elective surgery with general anesthesia endotracheal intubation. Statistically it was shown that there was no difference in effectiveness between Dexamethason 0.2 mg / kg and Lidocaine 1.5 mg / kgBB, but clinically the incidence of sore throat was higher in the Lidocaine group 1.5 mg / kgBB. Whereas at the 6th hour, Dexamethason 0.2 mg / kgBB statistically is more effective than Lidocaine 1.5 mg / kg in terms of reducing the incidence of sore throat after surgery.

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