Progression of Periodontitis in a Sample of Regular and Irregular Compliers Under Maintenance Therapy: A 3-Year Follow-Up Study

2011 ◽  
Vol 82 (9) ◽  
pp. 1279-1287 ◽  
Author(s):  
Fernando Oliveira Costa ◽  
Luís Otávio Miranda Cota ◽  
Eugênio José Pereira Lages ◽  
Telma Campos Medeiros Lorentz ◽  
Alcione Maria Soares Dutra Oliveira ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Follow Up Study

PAROXYSMAL TACHYCARDIA IN INFANCY: FOLLOW-UP STUDY OF 47 SUBJECTS RANGING IN AGE FROM 10 TO 26 YEARS

PEDIATRICS ◽  
1973 ◽  
Vol 51 (1) ◽  
pp. 26-35
Author(s):  
Åke Lundberg
Keyword(s):  
Physical Education ◽  
Maintenance Therapy ◽  
Physical Working Capacity ◽  
Working Capacity ◽  
Paroxysmal Tachycardia ◽  
Follow Up Study ◽  
The Past ◽  
Triggering Factor

A follow-up study of 47 individuals with paroxysmal tachycardia in infancy is reported. The incidence of recurrence decreases from 55% during infancy to 17% up to 10 years of age; a slight increase to 23% is then observed in adolescence. There is a higher incidence of paroxysm in cases with preexcitation in the ECG. Physical overexertion may be a triggering factor in recurrences, but exemption from school physical education and sports should only be granted exceptionally. No signs of reduced physical working capacity were found in this group. The results of maintenance therapy do not appear to have improved in the past decade.

The Expectation of Outcome from Maintenance Therapy in Chronic Schizophrenic Patients

1976 ◽  
Vol 128 (3) ◽  
pp. 246-250 ◽  
Author(s):  
D. A. W. Johnson
Keyword(s):  
Maintenance Therapy ◽  
Patient Population ◽  
Significant Proportion ◽  
Community Services ◽  
Neuroleptic Drugs ◽  
Follow Up Study ◽  
High Incidence ◽  
Schizophrenic Patients ◽  
Long Acting

SummaryThe results from a prospective follow-up study of a group of schizophrenic patients suggest that a significant proportion (41 per cent) are likely to relapse during a two-year period despite the prescription of long-acting injectable neuroleptic drugs. Some will relapse because of a failure of the regime, but others (32–37 per cent) because the pharmacological protection of these drugs would appear to be less effective in certain patients. Even with the major advantages of the long-acting injectable neuroleptics over oral medication, the schizophrenic patient population remains a group with a high incidence of psychiatric and social morbidity which continues to require the full resources of both the hospital and community services.

Progression of Periodontitis and Tooth Loss Associated with Glycemic Control in Individuals Undergoing Periodontal Maintenance Therapy: A 5-Year Follow-Up Study

2013 ◽  
Vol 84 (5) ◽  
pp. 595-605 ◽  
Author(s):  
Fernando Oliveira Costa ◽  
Luís Otávio Miranda Cota ◽  
Eugênio José Pereira Lages ◽  
Alcione Maria Soares Dutra Oliveira ◽  
Peterson Antônio Dutra Oliveira ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Maintenance Therapy ◽  
Tooth Loss ◽  
Follow Up Study ◽  
Periodontal Maintenance

Intraarterial 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) and Systemic Chemotherapy for Malignant Gliomas: A Follow-up Study

Neurosurgery ◽  
1983 ◽  
Vol 13 (4) ◽  
pp. 420-426 ◽  
Author(s):  
Charles R. West ◽  
Anthony M. Avellanosa ◽  
Nilou R. Barua ◽  
Arun Patel ◽  
Chung I. Hong
Keyword(s):  
Maintenance Therapy ◽  
Respiratory Infections ◽  
Malignant Gliomas ◽  
Pulmonary Emboli ◽  
Induction Periods ◽  
Vein Thrombosis ◽  
Follow Up Study ◽  
Upper Respiratory ◽  
Deep Vein

Abstract Twenty-five adults who harbored malignant gliomas received 72 courses of intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (100 mg/m2) and 67 courses of systemic vincristine (1.0 mg/m2) and procarbazine (100 mg/m2) as induction therapy (BVP) followed by 106 courses of systemic 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) (130 mg/m2), vincristine, and procarbazine as maintenance therapy (MVP). With a 6-week interval between each treatment, the median and range for the number of courses of BVP were 3 and 1 to 4 and those for MVP were 3 and 0 to 14, respectively. Fifteen patients (60%) responded to both BVP and MVP, and 10 (40%) did not. The overall median survival time was 12.7 months (range, 1.8 to 48.5+ months). Two of 3 patients who had recurrent gliomas responded and survived for 37+ to 45+ months. Seven of 10 who had nonirradiated glioblastomas responded and survived for 9 to 22 months. Four who had nonirradiated anaplastic astrocytomas all responded and survived for 38+ to 48.5+ months. Two who also received radiotherapy (1 glioblastoma and 1 primitive neuroectodermal tumor) benefited and survived for 16.9 and 28.5+ months. All who did not respond favorably died within 8 months. During the infusion of BCNU, complications included transient orbital and head pain, periorbital and scleral erythema in all patients, and a focal seizure in 1 (4%). During the 6-month induction periods, leukopenia and thrombocytopenia occurred in 1 (4%), deep vein thrombosis occurred in 9 (36%), pulmonary emboli occurred in 8 (32%), upper respiratory infections occurred in 6 (24%), pneumonia occurred in 9 (36%), and herpes zoster occurred in 1 (4%). During maintenance therapy, seizures occurred in 4 (16%) and leukopenia and/or thrombocytopenia occurred by the fifth course in 6 of 9 who received 5 to 14 treatments.

Follow-up Study of FK506 (Tacrolimus) Ointment in Patients with Atopic Dermatitis. What is Recommended as a Maintenance Therapy?

2002 ◽  
Vol 64 (6) ◽  
pp. 758-762
Author(s):  
Mitsuse INOUE ◽  
Shin’ichiro YASUMOTO ◽  
Takekuni NAKAMA ◽  
Osamu MORI ◽  
Takashi HASHIMOTO
Keyword(s):  
Atopic Dermatitis ◽  
Maintenance Therapy ◽  
Tacrolimus Ointment ◽  
Follow Up Study

scholarly journals Ten-Year Follow-Up of 100 Patients Admitted to a Mental Hospital

1972 ◽  
Vol 17 (6) ◽  
pp. 429-432
Author(s):  
Charles H. Cahn
Keyword(s):  
Drug Therapy ◽  
Maintenance Therapy ◽  
Mental Hospital ◽  
Government Support ◽  
Follow Up Study ◽  
Hospital Beds ◽  
Schizophrenic Patients ◽  
Organic Psychoses ◽  
One Year

A ten-year follow-up study of 100 patients admitted consecutively to a mental hospital revealed the following information. The patients used the hospital beds for an average of one year and two months of the ten years, that is, about. one-eighth of the time. The co-operative schizophrenic patients could be kept out of hospital with proper maintenance therapy. Patients admitted with organic psychoses died after an average of one and three-quarter years. Of the ‘functional’ cases nearly a half were alive after ten years, 8 were dead (2 or 3 suicides) and the rest could not be traced. The patients had an average of 23 physicians but this large number does not appear to have harmed them. Nearly all patients had some drug therapy, the two most frequently prescribed categories being neuroleptics and antidepressants. About half the patients had occupational and work therapy. The condition of the 68 survivors was considered to be: ‘recovered’ or ‘much improved’ in 55 per cent; ‘moderately or slightly improved’ in 40 per cent and ‘unimproved or worse’ in 3 per cent. Their last known vocational status was ‘working or self-sufficient’ in 34 per cent, ‘dependent’ upon relatives or government support in 43 per cent and not known in 23 per cent.

Long-Term Outcome of Six Months Maintenance Chemotherapy for ALL in Children: An Extended Follow up Study of TCCSG L92-13

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2262-2262
Author(s):  
Motohiro Kato ◽  
Atsushi Manabe ◽  
Sae Ishimaru ◽  
Daisuke Tomizawa ◽  
Daisuke Hasegawa ◽  
...  
Keyword(s):  
High Risk ◽  
Maintenance Therapy ◽  
Malignant Neoplasms ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Follow Up Study ◽  
Standard Risk ◽  
All Treatment

Abstract Maintenance therapy is a key component of ALL treatment. Although maintenance with 6-mercaptopurine (6-MP) and methotrexate (MTX) is generally less hemato-toxic, it occasionally causes severe complications such as infections, and too long maintenance is possibly associated with lower adherence. Thus, the duration of maintenance should be as short as possible, but excess shortening of maintenance therapy leads to high relapse incidence, as shown in our previous clinical trial, the Tokyo Children's Cancer Study Group (TCCSG) L92-13 (1992 - 1995, n = 347). In this study, the shortened maintenance therapy to 6 months resulted in EFS of 59.5% at 5.5 years although OS was as good as 81.5%. Especially, higher relapse rate in standard-risk (SR) resulted in EFS of as low as 60.2% (Toyoda Y, et al. J Clin Oncol 2000). However, it should be noted that about 60% of ALL achieved continuous complete remission (CCR) with short maintenance therapy. Thus, to confirm long-term outcome of ALL with this short maintenance therapy, we conducted an extended follow up study of patients enrolled on the TCCSG L92-13. In the L92-13 trial, previously untreated children (15 years or younger) with ALL were enrolled, and were assigned to three risk groups, standard-risk (SR), high-risk (HR) and extremely high-risk (HEX), according to age at diagnosis, immunephenotype, sentinel cytogenetics and initial leukocyte count. All patients received four-drug induction, followed by consolidation therapy including re-induction. Maintenance therapy with daily 6-MP and weekly MTX was shortened to 6 months, and all treatment was discontinued at 12 months after diagnosis. The data was analyzed as of 2014 July. A median of follow up period of this extended study was 14.8 years, and the survival curve is shown in Figure 1A. Relapse was reported in 128 patients, with a median time of relapse was 1.8 years from diagnosis. EFS at 12 years for all patients was 58.7 +- 2.7% (59.2% for SR [n = 127], 57.8% for intermediate-risk [IR, n = 122], and 59.2% for high-risk [HR, n = 101]) and OS was 78.7 +- 2.2% (85.4% for SR, 80.0% for IR, and 69.0% for HR). Incidences of relapse and non-relapse mortality were 37.2 +- 2.6% and 3.2 +- 0.9%, respectively. Five patients (0 in SR group, 3 in HR group, and 2 in HEX group) developed secondary malignant neoplasms before relapse, which resulted in cumulative incidence of secondary malignancy of 0.9 +- 0.5% at 12 years. Patient gender was associated with the outcome, and female had better EFS (65.3 +- 3.7%) compared to male (52.2 +- 3.8%) (p = 0.04, Figure 1B). High-hyperdiploid (HHD) patients had relatively worse prognosis, with EFS of 50.0 +- 11.8%, although it is generally considered as good prognostic factor, and most of the relapsed HHD patients were salvaged and OS was 94.4 +- 5.4%. It is confirmed that 6 months maintenance therapy is insufficient for male, HHD, and standard risk patients. In contrast, most of patients who had been in first CR at previous analysis maintained CCR status. Our results demonstrate that short maintenance therapy can cure a substantial portion of ALL with extremely low non-relapse mortality, and that it may be possible to shorten the duration of maintenance therapy for female and non-HHD patients. This study provides precise information of leukemia biology and highlights the role of maintenance therapy. Ongoing molecular characterization of the cured patients will clarify the subset of patients who can be cured with short maintenance therapy. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

The Role of Maintenance Therapy and Relatives' Expressed Emotion in Relapse of Schizophrenia: A Two-Year Follow-up

1981 ◽  
Vol 139 (2) ◽  
pp. 102-104 ◽  
Author(s):  
Julian Leff ◽  
Christine Vaughn
Keyword(s):  
Maintenance Therapy ◽  
Protective Effect ◽  
Expressed Emotion ◽  
Prophylactic Effect ◽  
Follow Up Study ◽  
Hospital Patients ◽  
Discharge From Hospital ◽  
Significant Protective Effect

SummaryA two-year follow-up study was conducted, mainly from case notes, of patients who had originally taken part in a study of the influence of relatives' expressed emotion on schizophrenic relapse. It was found that in the two years following discharge from hospital patients from high expressed emotion homes had a significantly greater relapse rate than those from low expressed emotion homes.The prophylactic effect of maintenance drugs was no longer evident for patients from high expressed emotion homes at the two-year follow-up. By contrast, a significant protective effect of maintenance therapy emerged for patients from low expressed emotion homes.The interpretation of these findings is discussed.

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