The Bone Formation Capabilities of the Anorganic Bone Matrix–Synthetic Cell-Binding Peptide 15 Grafts in an Animal Periodontal Model: A Histologic and Histomorphometric Study in Dogs

2010 ◽  
Vol 81 (4) ◽  
pp. 594-603 ◽  
Author(s):  
Flávia A. Suaid ◽  
Guilherme O. Macedo ◽  
Arthur B. Novaes ◽  
Germana J. Borges ◽  
Sérgio L.S. Souza ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Matrix ◽  
Cell Binding ◽  
Binding Peptide ◽  
Histomorphometric Study ◽  
Synthetic Cell

A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study

2007 ◽  
Vol 8 (6) ◽  
pp. 25-34 ◽  
Author(s):  
Manohar L. Bhongade ◽  
Ishan R. Tiwari
Keyword(s):  
Comparative Evaluation ◽  
Bone Matrix ◽  
Radiographic Study ◽  
Cell Binding ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Defect Sites ◽  
Synthetic Cell ◽  
Infrabony Defects ◽  
Open Flap Debridement

Abstract Aim The development of biologic modalities designed to enhance bone regeneration and wound healing of specific periodontal sites continues to unfold. This is accomplished through the cell binding activity of Type-I collagen provided by a synthetic cell binding peptide (P-15) which is incorporated in a scaffold of anorganic bovine matrix (ABM). This combination is designed to facilitate the attachment, migration, and differentiation of cells. The objective of this study is to clinically and radiographically evaluate the effectiveness of the combination of ABM and P-15 (ABM/P-15) ‘putty’ during regenerative periodontal procedures. Methods and Materials A total of 20 interproximal intraosseous defects in 16 patients, (8 males, 8 females), age 22-48 years (mean 34.45) were recruited and divided equally into two experimental groups. Following open flap debridement (OFD), the defect sites in a test group were grafted with a bovine-derived xenograft enriched with a cell binding peptide. The defect sites in a control group were treated with only OFD. Appropriate periodontal maintenance schedules were followed; at six months, clinical and radiographic assessments for soft tissue and hard tissue were performed for documentation and finalization of results. Results Statistical analysis using student paired ‘t’ test analyses of the patient mean value from the 16 patients revealed the ABM/P-15 ‘putty’ graft group demonstrated significantly better mean defect fill of 3.4 + 0.7 mm (70.5%) versus mean defect fill of 0.9 mm (17.33%) for defects treated with only OFD. Soft tissue findings showed significant differences among treatment with ABM/P-15 compared to OFD. Conclusions These results indicate the use of P-15 synthetic cell binding peptide combined with ABM yields better clinical results in conjunction with OFD than with OFD alone. Citation Bhongade ML, Tiwari IR. A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/ Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study. J Contemp Dent Pract 2007 September; (8)6:025-034.

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

2014 ◽  
Vol 103 (4) ◽  
pp. 1357-1365 ◽  
Author(s):  
Ming Ding ◽  
Christina M. Andreasen ◽  
Mads L. Dencker ◽  
Anders E. Jensen ◽  
Naseem Theilgaard ◽  
...  
Keyword(s):  
Bone Formation ◽  
Small Cell ◽  
Cell Binding ◽  
Implant Fixation ◽  
Binding Peptide

scholarly journals Effects of a Putty-Form Hydroxyapatite Matrix Combined With the Synthetic Cell-Binding Peptide P-15 on Alveolar Ridge Preservation

2008 ◽  
Vol 79 (2) ◽  
pp. 291-299 ◽  
Author(s):  
Rodrigo F. Neiva ◽  
Yi-Pin Tsao ◽  
Robert Eber ◽  
Jeffrey Shotwell ◽  
Edward Billy ◽  
...  
Keyword(s):  
Ridge Preservation ◽  
Alveolar Ridge ◽  
Cell Binding ◽  
Binding Peptide ◽  
Alveolar Ridge Preservation ◽  
Synthetic Cell

Ridge Preservation With Acellular Dermal Matrix and Anorganic Bone Matrix Cell-Binding Peptide P-15 After Tooth Extraction in Humans

2011 ◽  
Vol 82 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Patricia Garani Fernandes ◽  
Arthur B. Novaes ◽  
Adriana Correa de Queiroz ◽  
Sergio Luis Scombatti de Souza ◽  
Mario Taba ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Bone Matrix ◽  
Acellular Dermal Matrix ◽  
Ridge Preservation ◽  
Cell Binding ◽  
Dermal Matrix ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Acellular Dermal

Enhanced bone regeneration with a synthetic cell-binding peptide—in vivo results

2005 ◽  
Vol 329 (2) ◽  
pp. 789-795 ◽  
Author(s):  
Michael Thorwarth ◽  
Stefan Schultze-Mosgau ◽  
Falk Wehrhan ◽  
Safwan Srour ◽  
Joerg Wiltfang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Cell Binding ◽  
Binding Peptide ◽  
Synthetic Cell
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