Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans

2007 ◽  
Vol 78 (12) ◽  
pp. 2277-2283 ◽  
Author(s):  
Ana L. Eto ◽  
Julio C. Joly ◽  
Marjorie Jeffcoat ◽  
Ney S. de Araújo ◽  
Vera C. de Araújo ◽  
...  
Keyword(s):  
Class Ii ◽  
Radiographic Study ◽  
Cell Binding ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Furcation Defects

A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study

2007 ◽  
Vol 8 (6) ◽  
pp. 25-34 ◽  
Author(s):  
Manohar L. Bhongade ◽  
Ishan R. Tiwari
Keyword(s):  
Comparative Evaluation ◽  
Bone Matrix ◽  
Radiographic Study ◽  
Cell Binding ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Defect Sites ◽  
Synthetic Cell ◽  
Infrabony Defects ◽  
Open Flap Debridement

Abstract Aim The development of biologic modalities designed to enhance bone regeneration and wound healing of specific periodontal sites continues to unfold. This is accomplished through the cell binding activity of Type-I collagen provided by a synthetic cell binding peptide (P-15) which is incorporated in a scaffold of anorganic bovine matrix (ABM). This combination is designed to facilitate the attachment, migration, and differentiation of cells. The objective of this study is to clinically and radiographically evaluate the effectiveness of the combination of ABM and P-15 (ABM/P-15) ‘putty’ during regenerative periodontal procedures. Methods and Materials A total of 20 interproximal intraosseous defects in 16 patients, (8 males, 8 females), age 22-48 years (mean 34.45) were recruited and divided equally into two experimental groups. Following open flap debridement (OFD), the defect sites in a test group were grafted with a bovine-derived xenograft enriched with a cell binding peptide. The defect sites in a control group were treated with only OFD. Appropriate periodontal maintenance schedules were followed; at six months, clinical and radiographic assessments for soft tissue and hard tissue were performed for documentation and finalization of results. Results Statistical analysis using student paired ‘t’ test analyses of the patient mean value from the 16 patients revealed the ABM/P-15 ‘putty’ graft group demonstrated significantly better mean defect fill of 3.4 + 0.7 mm (70.5%) versus mean defect fill of 0.9 mm (17.33%) for defects treated with only OFD. Soft tissue findings showed significant differences among treatment with ABM/P-15 compared to OFD. Conclusions These results indicate the use of P-15 synthetic cell binding peptide combined with ABM yields better clinical results in conjunction with OFD than with OFD alone. Citation Bhongade ML, Tiwari IR. A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/ Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study. J Contemp Dent Pract 2007 September; (8)6:025-034.

Ridge Preservation With Acellular Dermal Matrix and Anorganic Bone Matrix Cell-Binding Peptide P-15 After Tooth Extraction in Humans

2011 ◽  
Vol 82 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Patricia Garani Fernandes ◽  
Arthur B. Novaes ◽  
Adriana Correa de Queiroz ◽  
Sergio Luis Scombatti de Souza ◽  
Mario Taba ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Bone Matrix ◽  
Acellular Dermal Matrix ◽  
Ridge Preservation ◽  
Cell Binding ◽  
Dermal Matrix ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Acellular Dermal

Clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide grafts for regeneration of periodontal defects: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Muhammad S Shaikh ◽  
Shehriar Husain ◽  
Mohid A Lone ◽  
Muneeb A Lone ◽  
Humera Akhlaq ◽  
...  
Keyword(s):  
Periodontal Regeneration ◽  
Clinical Effectiveness ◽  
Gingival Recession ◽  
Cochrane Library ◽  
Cell Binding ◽  
Intrabony Defects ◽  
Binding Peptide ◽  
Probing Depth ◽  
Matrix Cell ◽  
Significant Difference

Aim: To ascertain clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (ABM/P-15) for regeneration of periodontal defects. Materials & methods: Electronic databases (National Library of Medicine [Medline by PubMed], Cochrane Library [Wiley], CINAHL [EBSCO] and Medline [EBSCO]) were systematically searched up to December 2019. Randomized controlled clinical trials comparing ABM/P-15 grafts to conventional surgery for intrabony and gingival recession defects were included and evaluated intrabony defects including clinical attachment level (CAL), probing depth and gingival recession. Results: A significant gain in CAL (1.37 mm), and reduction in probing depth (1.22 mm) were shown by ABM/P-15 grafts than open flap debridement (p < 0.00001). The subgroup analysis also showed better results for ABM/P-15 grafts in CAL gain for intrabony defects. For furcation and gingival recession defects, no significant difference was seen. Conclusion: The adjunct use of ABM/P-15 grafts in conventional periodontal surgery is useful for periodontal regeneration of intrabony defects.

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