Morphometric, Histomorphometric, and Microcomputed Tomographic Analysis of Periodontal Inflammatory Lesions in a Murine Model

2007 ◽  
Vol 78 (6) ◽  
pp. 1120-1128 ◽  
Author(s):  
Chung Hsing Li ◽  
Salomon Amar
Keyword(s):  
Murine Model ◽  
Inflammatory Lesions ◽  
Tomographic Analysis

Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

2019 ◽  
Vol 26 (1) ◽  
pp. 66-79 ◽  
Author(s):  
Iris Stolzer ◽  
Valentina Kaden-Volynets ◽  
Barbara Ruder ◽  
Marilena Letizia ◽  
Miriam Bittel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Murine Model ◽  
Immune Reaction ◽  
Mucosal Barrier ◽  
Bacterial Clearance ◽  
Compelling Evidence ◽  
Susceptible Host ◽  
Inflammatory Lesions ◽  
Mucosal Barrier Function

Here we provide compelling evidence that inflammation in a murine model of Crohn’s disease–like inflammation is characterized by an immune reaction presumably directed at a disease-relevant microflora in a genetically susceptible host with impaired mucosal barrier function and bacterial clearance.

scholarly journals Curing Mycobacterium ulcerans Infection in Mice with a Combination of Rifampin-Streptomycin or Rifampin-Amikacin

2006 ◽  
Vol 51 (2) ◽  
pp. 645-650 ◽  
Author(s):  
Sébastien Lefrançois ◽  
Jérôme Robert ◽  
Aurélie Chauffour ◽  
Baohong Ji ◽  
Vincent Jarlier
Keyword(s):  
Murine Model ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Cure Rate ◽  
Duration Of Treatment ◽  
Inflammatory Lesions ◽  
Optimal Duration ◽  
Bactericidal Activities ◽  
The Difference ◽  
Cure Rates

ABSTRACT The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments. In the first experiment, treatment was begun 1 week after infection, when the inflammatory footpad lesion had not yet occurred (preventive model), and in the second experiment, treatment was begun 6 weeks after infection, when inflammatory footpad lesions were established (curative model). In the first experiment, 4 weeks of treatment with daily RIF-STR or RIF-AMK was able to postpone the occurrence of footpad lesion by 12 weeks (RIF-STR) or 17 weeks (RIF-AMK), thus demonstrating their promising bactericidal activities, but neither treatment was able to prevent the late occurrence of footpad lesions. In the second experiment, the overall cure rates, as assessed by the lack of rebound of inflammatory lesions or remultiplication of M. ulcerans, were only 62% after 2 weeks of treatment with RIF and an aminoglycoside and 85% after 4 weeks; but the cure rate reached 100% after 8 or 12 weeks of treatment. The cure rates were slightly higher with the AMK-containing combination than with the STR-containing combination, but the difference was at the limit of significance (P = 0.07). These results show that in the murine model of Buruli ulcer, 8 weeks is the optimal duration of treatment with a combination of RIF and an aminoglycoside.

Effect of Azithromycin on Acute Inflammatory Lesions and Colonic Bacterial Load in a Murine Model of Experimental Colitis

2009 ◽  
Vol 55 (8) ◽  
pp. 2211-2218 ◽  
Author(s):  
Sanja Pleško ◽  
Marko Banić ◽  
Vanda Plečko ◽  
Branimir Anić ◽  
Tomislav Brkić ◽  
...  
Keyword(s):  
Murine Model ◽  
Bacterial Load ◽  
Experimental Colitis ◽  
Inflammatory Lesions

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Anti-OX40ligand treatment as a novel therapeutic strategy in a murine model of colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A685-A685
Author(s):  
B SINGH ◽  
V MALMSTROM ◽  
F POWRIE
Keyword(s):  
Murine Model ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

404: Immune Mediated Survival Advantage and Primary Tumor Control of Cryoablation Compared to Nephrectomy in a Murine Model of Advanced Renal Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132 ◽  
Author(s):  
Sean P. Hedican ◽  
Eric R. Wilkinson ◽  
Thomas F. Warner ◽  
Fred T. Lee ◽  
Stephen Y. Nakada
Keyword(s):  
Renal Cancer ◽  
Murine Model ◽  
Primary Tumor ◽  
Survival Advantage ◽  
Tumor Control ◽  
Advanced Renal Cancer ◽  
Immune Mediated
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