Five-Year Follow-Up of Regenerative Periodontal Therapy With Enamel Matrix Derivative at Sites With Angular Bone Defects

2006 ◽  
Vol 77 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Gunnar Heden ◽  
Jan L. Wennström
Keyword(s):  
Bone Defects ◽  
Periodontal Therapy ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Regenerative Periodontal Therapy ◽  
Matrix Derivative

Effect of Enamel Matrix Derivative (Emdogain) on Bone Defects in Rabbit Tibias

2004 ◽  
Vol 30 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Roberto Cornelini ◽  
Antonio Scarano ◽  
Maurizio Piattelli ◽  
Sebastiano Andreana ◽  
Ugo Covani ◽  
...  
Keyword(s):  
Test Group ◽  
Inflammatory Cells ◽  
Bone Defects ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
The Right ◽  
Observation Times ◽  
Microscopy Examination ◽  
Observation Period ◽  
Matrix Derivative

Abstract The aim of this study was to assess the effect of an enamel matrix derivative (Emdogain, Biora, AB, Malmö, Sweden) on bone healing. Ten New Zealand rabbits, weighing about 2.5 kg, were used. One 8-mm bone defect was created in each tibia. The defect on the right leg was filled with Emdogain, whereas the defect on the opposite leg was left unfilled as control. A total of 20 defects were created. Five rabbits each were killed at 4 and 8 weeks with an overdose of Tanax. Block sections containing the defects were retrieved and the specimens processed for light microscopy examination. The slides were stained with acid and basic fuchsin and toluidine blue. Histologically, no differences were noted in both groups at each observation period; in the test group, remnants of the implanted Emdogain were not present at 4 weeks. Newly formed bone was detectable in both groups at all observation times. At 8 weeks, both groups showed mature bone, and in the test group the material implanted was not visible. No inflammatory cells were visible in both groups. In conclusion, our results indicate that Emdogain implanted in bone defects is fully resorbed after 4 to 8 weeks and does not adversely affect bone formation.

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