Histologic Evaluation of Periodontal Healing in Humans Following Regenerative Therapy With Enamel Matrix Derivative. A 10-Case Series

2000 ◽  
Vol 71 (5) ◽  
pp. 752-759 ◽  
Author(s):  
Raymond A. Yukna ◽  
James T. Mellonig
Keyword(s):  
Case Series ◽  
Enamel Matrix Derivative ◽  
Regenerative Therapy ◽  
Enamel Matrix ◽  
Histologic Evaluation ◽  
Periodontal Healing ◽  
Matrix Derivative

scholarly journals Guided bone regeneration using enamel matrix derivative for implant treatments: Case series

2019 ◽  
Vol 39 (1-2) ◽  
pp. 53-61
Author(s):  
Yoshiyuki Wada ◽  
Masazumi Yoshitani ◽  
Motomasa Itabashi ◽  
Harunori Yoshimura ◽  
Itaru Mikami
Keyword(s):  
Bone Regeneration ◽  
Case Series ◽  
Guided Bone Regeneration ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3045
Author(s):  
Alice Alberti ◽  
Luca Francetti ◽  
Silvio Taschieri ◽  
Stefano Corbella
Keyword(s):  
Clinical Trials ◽  
Bone Regeneration ◽  
Randomized Clinical Trials ◽  
Periodontal Regeneration ◽  
Case Series ◽  
Titanium Implants ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Implant Placement ◽  
Matrix Derivative

Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy.

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