scholarly journals Adult Pancreatic Alpha-Cells: A New Source of Cells for Beta-Cell Regeneration

2010 ◽  
Vol 7 (2) ◽  
pp. 124-131 ◽  
Author(s):  
Cheng-Ho Chung ◽  
Fred Levine
Keyword(s):  
Beta Cell ◽  
Cell Regeneration ◽  
Alpha Cells ◽  
Beta Cell Regeneration ◽  
Pancreatic Alpha Cells

Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan

Diabetes ◽  
1997 ◽  
Vol 46 (8) ◽  
pp. 1281-1290 ◽  
Author(s):  
M. Waguri ◽  
K. Yamamoto ◽  
J. I. Miyagawa ◽  
Y. Tochino ◽  
K. Yamamori ◽  
...  
Keyword(s):  
Mouse Model ◽  
Beta Cell ◽  
Diabetic Mouse ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Selective Perfusion

Ultrasound‐Targeted Microbubble Destruction Mediates Gene Transfection for Beta‐Cell Regeneration and Glucose Regulation

Small ◽  
2021 ◽  
pp. 2008177
Author(s):  
Chao Zhang ◽  
Shuyuan Chen ◽  
Qunying Li ◽  
Jiao Wu ◽  
Fuqiang Qiu ◽  
...  
Keyword(s):  
Beta Cell ◽  
Gene Transfection ◽  
Glucose Regulation ◽  
Cell Regeneration ◽  
Beta Cell Regeneration

Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients

2004 ◽  
Vol 34 (11) ◽  
pp. 752-758 ◽  
Author(s):  
N. J. Shervani ◽  
S. Takasawa ◽  
Y. Uchigata ◽  
T. Akiyama ◽  
K. Nakagawa ◽  
...  
Keyword(s):  
Beta Cell ◽  
Diabetic Patients ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Regeneration Factor

scholarly journals In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats

Diabetologia ◽  
2015 ◽  
Vol 58 (5) ◽  
pp. 1036-1044 ◽  
Author(s):  
Jiaxi Chen ◽  
Shuyuan Chen ◽  
Pintong Huang ◽  
Xing-Li Meng ◽  
Sandra Clayton ◽  
...  
Keyword(s):  
Beta Cell ◽  
Targeted Delivery ◽  
Cell Regeneration ◽  
Beta Cell Regeneration

The HGF/cMet Signaling Pathway Is Essential for Pancreatic Beta-Cell Regeneration.

2010 ◽  
pp. OR32-3-OR32-3
Author(s):  
SJ Ernst ◽  
C Demirci ◽  
JM Mellado-Gil ◽  
TC Rosa ◽  
SR Valle ◽  
...  
Keyword(s):  
Beta Cell ◽  
Signaling Pathway ◽  
Pancreatic Beta Cell ◽  
Cell Regeneration ◽  
Beta Cell Regeneration

scholarly journals Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells

2015 ◽  
Vol 36 (5) ◽  
pp. 1735-1742 ◽  
Author(s):  
Ling Chen ◽  
Jing Zhang ◽  
Zhuo Zhang ◽  
Yaping Chu ◽  
Bing Song ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Beta Cells ◽  
Cell Number ◽  
Diabetic Patients ◽  
Alpha Cells ◽  
Diabetic Mice ◽  
Glucose Response ◽  
Pancreatic Alpha Cells

Background/Aims: The lack of available beta cells greatly limits the use of beta cell transplantation as a therapy for diabetes. Thus, generation of beta cells from other sources is substantially required. Pax4 has been shown to induce reprograming of alpha cells into beta cells during embryogenesis. Nevertheless, whether expression of Pax4 in adult alpha cells could trigger this alpha-to-beta cell reprogramming is unknown. Methods: Here we generated an adeno-associated virus carrying Pax4 and GFP under a CMV promoter (AAV-Pax4). We used AAV-Pax4 to transduce a mouse alpha cell line in vitro, and to transduce primary alpha cells in diabetic mice. Reprogramming was examined by double immunostaining and by changes in beta cell number. The effects on blood glucose were evaluated by fasting blood glucose and glucose response. Results: In vitro, Pax4 overexpression neither induced insulin expression, nor suppressed glucagon expression in alpha cells. In vivo, Pax4 overexpression failed to increase beta cell number, and did not alter hyperglycemia and glucose response in diabetic mice. Conclusion: Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients.

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