Perceived Health and Functional Status and Work Environmental Factors as Determinants of Psychological Stress Among Employed People With Multiple Sclerosis

2020 ◽  
Vol 34 (3) ◽  
pp. 145-158 ◽  
Author(s):  
Jian Li ◽  
Phillip Rumrill ◽  
Malachy Bishop ◽  
Mykal Leslie
Keyword(s):  
Multiple Sclerosis ◽  
Environmental Factors ◽  
Psychological Stress ◽  
Perceived Stress ◽  
Career Decision Making ◽  
Lower Stress ◽  
Hierarchical Multiple Regression ◽  
Final Model ◽  
And Function

PurposeThis correlational study examined relationships among (a) health and function factors, (b) work environmental factors, and (c) perceived psychological stress among employed people with multiple sclerosis (MS).MethodBased on responses to a national survey by 523 employed people with MS, this study used a hierarchical multiple regression analysis.ResultsThe final model explained 30% of the variability in participants' perceived stress scores. Participants who perceived better overall health, who experienced less severe cognitive impairment, who expressed higher levels of job satisfaction, and who did not receive accommodations at work reported lower stress scores than did other participants.ImplicationsThe important role of stress in employment and career decision-making underscores the value of tailored psychosocial, medical, and vocational interventions for employed people with MS.

scholarly journals Paramyxoviruses and Multiple Sclerosis

2012 ◽  
Vol 9 (3) ◽  
pp. 500-503
Author(s):  
Baghdad Science Journal
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Neurological Disease ◽  
Epidemiological Data ◽  
Igg Antibodies ◽  
Significant Difference ◽  
Elisa Technique

Multiple Sclerosis (MS) is a progressive neurological disease characterized by periods of quiescence and exacerbation, epidemiological data suggest the notion that MS is an acquired autoimmune disease caused by environmental factors, probably infectious, in genetically susceptible individuals.The submitted research was attempted to study the possible viral (Paramyxoviruses) role in MS, the sera of 57 MS patients were assayed for anti-measles and anti-mumps IgG antibodies using ELISA technique, the results were compared in order to establish the presence or absence of a significant difference regarding both number of positive cases and antibodies titer between the two groups, the results revealed that there is no in number of measles positive cases in both MS patients and controls while a significant difference in number of positive cases of mumps and measles anti-measles IgG titer and a highly significant difference regarding mumps IgG Abs titer between the two studied groups, this may be considered as a preliminary indicator to the role of those two paramyxoviruses in MS.

scholarly journals 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Nathalie Deckx ◽  
Inez Wens ◽  
Amber H. Nuyts ◽  
Niel Hens ◽  
Benedicte Y. De Winter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Inflammatory Mediators ◽  
Exercise Program ◽  
Underlying Disease ◽  
Peripheral Tolerance ◽  
Controlled Clinical Trial ◽  
Tissue Mass ◽  
Markers Of Inflammation ◽  
And Function

Previously, we reported that patients with multiple sclerosis (MS) demonstrate improved muscle strength, exercise tolerance, and lean tissue mass following a combined endurance and resistance exercise program. However, the effect of exercise on the underlying disease pathogenesis remains elusive. Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. We demonstrate an increased number of plasmacytoid DC (pDC) following the exercise program. These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L+and CD80+pDC. Interestingly, the number of CD80+pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. In addition, decreased production of the inflammatory mediators, TNF-αand MMP-9, upon Toll-like receptor (TLR) stimulation was found at the end of the exercise program. Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the immunoregulatory function of circulating pDC, suggestive for a favorable impact of exercise on the underlying immunopathogenesis of MS.

scholarly journals Mediating Role of Sense of Coherence in the Relationship of Perceived Stress with Fatigue and Pain in Multiple Sclerosis Patients

2021 ◽  
Vol 14 (11) ◽  
pp. 38-47
Author(s):  
Samira Zarrabi-Ajami ◽  
Hadi Zamanian ◽  
Adis Kraskian Mujembari ◽  
Sara Pashang ◽  
◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Perceived Stress ◽  
Sense Of Coherence ◽  
Mediating Role ◽  
Multiple Sclerosis Patients ◽  
Relationship Of ◽  
The Relationship

Psychological Stress and Cytokine Production in Multiple Sclerosis

2011 ◽  
Vol 15 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Matthew Sorenson ◽  
Linda Janusek ◽  
Herbert Mathews
Keyword(s):  
Multiple Sclerosis ◽  
Psychological Stress ◽  
Perceived Stress ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Mood Disturbance ◽  
Peripheral Blood Mononuclear ◽  
Disease Symptoms ◽  
Tnf Α

Objective:Psychological variables such as perceived stress appear to play a role in symptom onset or disease exacerbation in multiple sclerosis (MS). The authors sought to determine if perceived stress is indeed associated with the expression of pro-inflammatory cytokines and disease symptoms in individuals with MS. To do so, the authors examined the relationships among disease symptomatology, perceived stress, and cytokine production from peripheral blood mononuclear cells in 42 outpatients with MS and 36 normative controls.Method:The authors drew peripheral blood from all subjects prior to the completion of a series of psychological instruments. The authors measured stress using the Perceived Stress scale and negative mood with the Profile of Mood States. Disease symptoms were measured using the Multiple Sclerosis Symptom Checklist. Cytokine production was induced separately by lipopolysaccharide and a combination of phytohemagglutinin and phorbol-12-myristate-13-acetate.Results:In MS subjects, the induced production of interleukin (IL)-6 and IL-10 positively correlated with psychological stress, mood disturbance, and disease symptomatology. In contrast, psychological stress in control subjects significantly correlated with level of tumor necrosis factor-alpha (TNF-α), and mood disturbance correlated with levels of TNF-α and interferon-gamma. As well, compared to controls, MS subjects exhibited a significant fourfold increase in the production of IL-12.Conclusion:There is, in those with MS, a pattern of IL-6 and IL-10 production that correlates significantly with perceived stress and disease symptomatology.

scholarly journals Synaptic Dysfunction in Multiple Sclerosis: A Red Thread from Inflammation to Network Disconnection

2021 ◽  
Vol 22 (18) ◽  
pp. 9753
Author(s):  
Laura Bellingacci ◽  
Andrea Mancini ◽  
Lorenzo Gaetani ◽  
Alessandro Tozzi ◽  
Lucilla Parnetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Networks ◽  
Chronic Inflammatory Disease ◽  
Brain Network ◽  
Structure And Function ◽  
Synaptic Dysfunction ◽  
Synaptic Failure ◽  
And Function ◽  
Synaptic Structures

Multiple sclerosis (MS) has been clinically considered a chronic inflammatory disease of the white matter; however, in the last decade growing evidence supported an important role of gray matter pathology as a major contributor of MS-related disability and the involvement of synaptic structures assumed a key role in the pathophysiology of the disease. Synaptic contacts are considered central units in the information flow, involved in synaptic transmission and plasticity, critical processes for the shaping and functioning of brain networks. During the course of MS, the immune system and its diffusible mediators interact with synaptic structures leading to changes in their structure and function, influencing brain network dynamics. The purpose of this review is to provide an overview of the existing literature on synaptic involvement during experimental and human MS, in order to understand the mechanisms by which synaptic failure eventually leads to brain networks alterations and contributes to disabling MS symptoms and disease progression.

scholarly journals Impact of Andropause on Multiple Sclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria C. Ysrraelit ◽  
Jorge Correale
Keyword(s):  
Multiple Sclerosis ◽  
Age Of Onset ◽  
Adaptive Immune Response ◽  
Epidemiological Studies ◽  
Testosterone Levels ◽  
Adaptive Immune ◽  
Natural Decrease ◽  
And Function ◽  
Gonadal Failure

Andropause results from the natural decrease in testosterone levels that occurs with age. In contrast to menopause, which is a universal, well-characterized process associated with absolute gonadal failure, andropause ensues after gradual decline of both hypothalamic-pituitary-gonadal axis activity, as well as of testicular function, a process which usually develops over a period of many years. Increasing evidence on greater risk of Multiple sclerosis (MS) associated with lower testosterone levels is being reported. Likewise, epidemiological studies have shown a later age of onset of MS in men, relative to women, which could perhaps respond to the decline in protective testosterone levels. In this review, we will discuss the role of androgens in the development and function of the innate and adaptive immune response, as well as in neuroprotective mechanisms relevant to MS. Testosterone effects observed in different animal models and in epidemiological studies in humans will be discussed, as well as their correlation with physical disability and cognitive function levels. Finally, published and ongoing clinical trials exploring the role of androgens, particularly at key stages of sexual maturation, will be reviewed.

scholarly journals Multiple sclerosis: environmental risk factors

1998 ◽  
Vol XXX (1-2) ◽  
pp. 40-42
Author(s):  
Enrico Granieri ◽  
Ilaria Casetta
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Environmental Factors ◽  
Environmental Risk ◽  
Biological Significance ◽  
Unknown Etiology ◽  
Brain And Spinal Cord ◽  
The Brain

Multiple sclerosis is a disease of unknown etiology characterized by inflammory demyelination of the brain and spinal cord. Epidemiological investigations play important role in study of multiple sclerosis. Geographical distribution of the disease has been described in terms of prevalence and incidence. The possible role of environmental factors as a cause of multiple sclerosis had been hypothesized with observation of unequal geographic distribution of the disease. More interesting, in terms of their biological significance, are attempts to identify associations between multiple sclerosis and situations or events wich could cause blood-brain barrier damages, such as trauma or toxic exposures.

scholarly journals Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis

2018 ◽  
Vol 69 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Aylin Elkama ◽  
Bensu Karahalil
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Environmental Factors ◽  
Gene Polymorphisms ◽  
Neurological Impairment ◽  
Vitamin D Metabolism ◽  
Vitamin D Levels ◽  
The Central Nervous System ◽  
Genetic And Environmental Factors

Abstract Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) resulting in neurological impairment and disability. There is evidence that adequate vitamin D levels may lower the risk of MS development. The aetiology of MS is complex and involves both genetic and environmental factors. In fact, not one but several genes are believed to lead to the disease. As for environmental factors, one of the most important risk factors is vitamin D deficiency, which, in turn, is closely related to gene polymorphisms that play a role in vitamin D metabolism and regulation. However, information about these gene polymorphisms is quite contradictory. The aim of this review is to discuss the association between some of the vitamin D-related gene variants and MS.

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