8.4: Contrast-Enhanced High-Speed Polarization Modulator for Active-Retarder 3D Displays

2011 ◽  
Vol 42 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Jesper Osterman ◽  
Terry Scheffer
Keyword(s):  
High Speed ◽  
Polarization Modulator ◽  
Contrast Enhanced ◽  
3D Displays

Abstract 5763: Dynamic Contrast-Enhanced MRI Detects Early Plaque Progression in a Rabbit Model of Atherosclerosis

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
William S Kerwin ◽  
Jerry Ricks ◽  
Michael Rosenfeld
Keyword(s):  
Vessel Wall ◽  
High Speed ◽  
Rabbit Model ◽  
Atherosclerotic Lesion ◽  
Intraplaque Hemorrhage ◽  
Slice Thickness ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Plaque Inflammation

Recent studies have used dynamic contrast-enhanced (DCE) MRI to quantify the rate of uptake of gadolinium contrast agents in atherosclerotic plaque. The transfer constant K trans , that quantifies the blood supply and permeability of the plaque, shows strong association with plaque inflammation. The purpose of this study was to explore the link between K trans and plaque inflammation in a model of early atherosclerotic lesion development. Twelve NZW rabbits were placed on a 0.2% cholesterol diet and underwent balloon injury of the descending aorta. After 12 weeks, all rabbits underwent a DCE-MRI exam, after which 6 were euthanized and perfusion fixed to harvest the atherosclerotic aortas. The remaining 6 were imaged again at 24 weeks and their aortas were harvested. The DCE-MRI procedure utilized a unique, high-speed, small field-of-view imaging technique with quadruple inversion recovery blood suppression (turbo spin echo, TR=800 ms, TE=9ms, 3mm slice thickness, 0.5mm in-plane resolution). This allowed us to observe enhancement of the vessel wall without contamination from enhancement of the adjacent lumen. The DCE-MRI results were analyzed to determine the average, relative K trans in the vessel wall and compared to histological assessments of the aortas. K trans was significantly higher at 6 months compared to 3 months within the same animals (p<0.005) and compared to those euthanized at 3 months (p<0.001). No difference was observed between the two groups at 3 months (p=0.4). Histologically, aorta cross sections at 6 months had lesions that were no thicker than those at 3 months (0.49 vs. 0.45mm, p=0.6), but complex lesion features including necrotic cores, intraplaque hemorrhage, neovessels, and deep clusters of macrophages were significantly more common at 6 months (82% vs. 18%, p<0.001). The transformation of the lesions from simple to complex morphologies from 12 weeks to 24 coincided with a significant rise in K trans . We attribute this rise to the development of neovessels in response to pro-inflammatory stimuli. We conclude that K trans can be used to probe lesion characteristics and complexity in early atherosclerosis, with applications in early diagnosis and treatment monitoring. This research has received full or partial funding support from the American Heart Association, AHA Pacific/Mountain Affiliate (Alaska, Arizona, Colorado, Hawaii, Idaho, Montana, Oregon, Washington & Wyoming).

High-speed waveguide electro-optic polarization modulator

1982 ◽  
Vol 7 (10) ◽  
pp. 500 ◽  
Author(s):  
R. C. Alferness ◽  
L. L. Buhl
Keyword(s):  
High Speed ◽  
Polarization Modulator ◽  
Electro Optic

High-speed imaging and tracking of very small single nanoparticles by contrast enhanced microscopy

Nanoscale ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 568-577 ◽  
Author(s):  
Ching-Ya Cheng ◽  
Yi-Hung Liao ◽  
Chia-Lung Hsieh
Keyword(s):  
High Speed ◽  
Direct Visualization ◽  
High Speed Imaging ◽  
Contrast Enhanced

Direct visualization of single 10 nm nanoparticles at 1000 frames per second is achieved by using coherent brightfield (COBRI) microscopy.

scholarly journals A high speed 2×2 electro-optic switch using a polarization modulator

2007 ◽  
Vol 15 (25) ◽  
pp. 16500 ◽  
Author(s):  
Qing Wang ◽  
Jianping Yao
Keyword(s):  
High Speed ◽  
Polarization Modulator ◽  
Electro Optic

scholarly journals Contrast Enhanced Subsurface Fingerprint Detection Using High-Speed Optical Coherence Tomography

2017 ◽  
Vol 29 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Xiaojun Yu ◽  
Qiaozhou Xiong ◽  
Yuemei Luo ◽  
Nanshuo Wang ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Optical Coherence ◽  
Contrast Enhanced ◽  
Fingerprint Detection

scholarly journals Nomarski serial time-encoded amplified microscopy for high-speed contrast-enhanced imaging of transparent media

2011 ◽  
Vol 2 (12) ◽  
pp. 3387 ◽  
Author(s):  
Ali M. Fard ◽  
Ata Mahjoubfar ◽  
Keisuke Goda ◽  
Daniel R. Gossett ◽  
Dino Di Carlo ◽  
...  
Keyword(s):  
High Speed ◽  
Contrast Enhanced ◽  
Transparent Media ◽  
Enhanced Imaging

scholarly journals High-Speed MR Imaging of Ischemic Brain Injury following Stenosis of the Middle Cerebral Artery

1993 ◽  
Vol 13 (6) ◽  
pp. 940-946 ◽  
Author(s):  
T. P. L. Roberts ◽  
Z. Vexler ◽  
N. Derugin ◽  
M. E. Moseley ◽  
J. Kucharczyk
Keyword(s):  
Magnetic Susceptibility ◽  
Cerebral Ischemia ◽  
Mr Imaging ◽  
Middle Cerebral Artery ◽  
Contrast Enhancement ◽  
High Speed ◽  
Ischemic Brain ◽  
Contrast Enhanced ◽  
Susceptibility Contrast ◽  
Echo Planar

Magnetic susceptibility contrast-enhanced and diffusion-weighted echo planar magnetic resonance (MR) imaging was performed using a cat model of acute regional cerebral ischemia induced by partial stenosis of the right middle cerebral artery (MCA). The imaging data were correlated with triphenyltetrazolium chloride (TTC)-stained histopathologic coronal brain sections to determine the prognostic efficacy of high-speed MR imaging techniques in differentiating mild, moderate, and severe cerebral hypoperfusion. Brains of animals without cortical injury on TTC staining were found to have a reduction in peak contrast enhancement of 32 ± 6% (mean ± SD) below control values with no significant change in the apparent diffusion coefficient (ADC), determined from the diffusion-weighted MR images. In cases where moderate ischemic injury was observed in the TTC-stained sections, a 10–20% drop in the ADC was found over the 6-h study period, accompanied by a much wider variation in peak contrast enhancement. Finally, where TTC staining showed severe ischemic brain damage, a 40–50% drop in ADC and a reduction in peak contrast enhancement effect of >95% were observed as early as 1 h following MCA stenosis. The significant correlation between imaging observations and histologically confirmed cerebral ischemia indicates that magnetic susceptibility contrast-enhanced echo planar MR imaging is sensitive to slight reductions in cerebral perfusion that fall below the threshold for reliably detectable ischemia-induced alterations in ADC. First-pass perfusion-sensitive imaging may thus be diagnostically useful in differentiating severely hypoperfused permanently injured tissue from the mildly hypoperfused ischemic penumbra.

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