scholarly journals In dogs with atopic dermatitis, are antihistamines as effective as glucocorticoids at reducing the severity of clinical signs?

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Sarah Long
Keyword(s):  
Atopic Dermatitis ◽  
Statistical Analysis ◽  
Controlled Trial ◽  
Clinical Signs ◽  
Small Pilot Study ◽  
Quality Of Evidence ◽  
The Third ◽  
Trial Testing ◽  
Randomised Control Trials

There is little evidence in the veterinary literature to determine if antihistamines are as effective as glucocorticoids in the management of atopic dermatitis in dogs. Two randomised control trials directly compared an antihistamine, fexofenadine, to methylprednisolone although one was a small pilot study and only used four dogs in each treatment group. The third study was a cross-over placebo-controlled trial testing a variety of antihistamines and prednisone with limited reporting of statistical analysis of the data. None provide sufficient quality of evidence to recommend the use of antihistamines over glucocorticoids and further comparative study is needed.

scholarly journals Efektivitas Suplementasi Filtrat Jambu Biji dalam Pengencer AirKelapa-Kuning Telur terhadap Kualitas Semen Cair Sapi Bali (THE EFFECTIVENESS OF GUAVA FILTRATE SUPPLEMENTATION IN COCONUT WATER-EGG YOLK DILUTION ON QUALITY OF LIQUID SEMEN OF BALI CATTLE)

2019 ◽  
Vol 20 (1) ◽  
pp. 20 ◽  
Author(s):  
ALoysius Marawali ◽  
Muhammad S. Abdullah ◽  
Jalaludin Jalaludin
Keyword(s):  
Statistical Analysis ◽  
Cold Shock ◽  
Egg Yolk ◽  
Coconut Water ◽  
The Third ◽  
Bali Cattle ◽  
Artificial Vagina

The aim of this research was to know the effectiveness of guava filtrate supplementation in coconut water- egg yolk dilution on quality of liquid semen stored at 5oC of Bali cattle. Semen collected from a five year old Bali cattle using artificial vagina. Semen of good quality were kept in six tubes based on treatment then stored at 5oC. Treatments of the research were P0 : coconut water 80% + egg yolk 20% without guava filtrate; P1 : coconut water 80% + egg yolk 20% + 0.8% guava filtrate; P2 : coconut water 80% + egg yolk 20% + 0.9% guava filtrate; P3 : coconut water 80% + egg yolk 20% + 1.0 % guava filtrate; P4 : coconut water 80% + egg yolk 20% + 1.1 % guava filtrate and P5 : coconut water 80% + egg yolk 20% + 1.2 % guava filtrate. Each treatment was replicated 8 times making 48 experimental units. Results of the study showed that percentage mean of motility, viability, MPU, and TAU of spermatozoa after three days storage for P0 were : 42.20%, 41.85%, 39.08% and 40.90%; P1 : 50.40%, 53.89%, 52.99% and 54.67%; P2 : 54.67%, 56.97%, 54.51% and 54.36%; P3 : 17.00%, 29.96%, 29.64% and 29.64%; P4 : 23.38%, 24.64%, 21.06% and 24.45%Jurnal Veteriner Maret 2019 Vol. 20 No. 1 : 20 -29 pISSN: 1411-8327; eISSN: 2477-5665 DOI: 10.19087/jveteriner.2019.20.1.20 Terakreditasi Nasional, Dirjen Penguatan Riset dan Pengembangan, online pada http://ojs.unud.ac.id/index.php/jvet Kemenristek Dikti RI S.K. No. 36a/E/KPT/201621PENDAHULUAN Salah satu solusi yang dapat digunakan untuk pengembangan program Inseminasi buatan (IB) secara cepat dan mudah pada sapi bali adalah penggunaan semen cair. Penggunaan semen cair dapat meningkatkan kinerja IB pada sapi bali di Nusa Tenggara Timur (NTT). Keunggulan lain semen cair dapat diproduksi menggunakan bahan pengencer herbal berbasis bahan lokal dan peralatan yang sederhana serta mudah diperoleh dan tidak tergantung dengan persediaan nitrogen cair. Hasil akhir dari metabolisme spermatozoa adalah terbentuknya radikal bebas berupa derivat oksigen di antaranya adalah single1 oksigen (1O2), tripel1 oksigen (3O2), superokside anion (O2-), hidroksil radikal (OH) dan nitrit oxide (NO-) yang semuanya disebut radical oksigen species (ROS). Single1 oksigen dapat merusak ikatan rangkap pada asam lemak sehingga dapat menyebabkan kerusakan Deoxyribo Nuclead Acid (DNA) dan protein. Single1 oksigen bila bereaksi dengan asam amino histidin akan membentuk enzim yang dapat menyebabkan denaturasi protein. Kerusakan spermatozoa pada penyimpanan suhu 5%C akibat radikal bebas dan cold shock inilah merupakan penyebab utama disfungsi semen (Sharma et al., 2000). Oksidasi fosforilasi yang terganggu menyebabkan peningkatan radikal bebas dalam semen. Kadar radikal bebas yang terganggu menyebabkan peningkatan radikal bebas dalam semen. Kadar radikal bebas yang tinggi dalam sel dapat mengoksidasi lipid, protein dan DNA. Lipid membran plasma semen memiliki fosfolipid dengan kadar yang tinggi menyebabkan semen rentan terhadap radikal bebas (Sanoeka dan Kurpisz, 2004). Antioksidan bertindak mengikat asam lemak tak jenuh dan mencegah terjadinyareaksi berantai. Pada proses penyimpanan semen akan terjadi kerusakan membran plasma spermatozoa akibat terbentuknya perioksidasi lipid. Antioksidan-pemutus rantai seperti yang terkandung dalam jambu biji dapat menghambat perioksidasi lipid dalam membran melalui radical peroxyl (RO) dan alkoxyl (ROO) pengurai. Pengunaan jambu biji yang difilter dalam pengencer air kelapa kuning telur dapat menjaga kualitas spermatozoa (motilitas, keutuhan akrosom, viabilitas dan morfologi spermatozoa) semen cair sapi bali selama penyimpanan pada suhu 5%C. Dosis jambu biji yang difilter yang terbaik dalam pengencer air kelapa kuning telur, akan terbaik pula dalam mempertahankan kualitas spermatozoa sampai tujuan IB. Adapun tujuan penelitian ini adalah menguji berbagai level pemberian filtrat jambu biji (FJB) dalam pengencer air kelapa kuning telur terhadap motilitas, viabilitas, membran plasma utuh (MPU) dan tudung akrosom utuh (TAU) spermatozoa sapi bali yang disimpan pada suhu 5%C.METODE PENELITIAN Penelitian ini telah dilakukan di Laboratorium Reproduksi milik Yayasan Wiliams dan Laura yang berlokasi di Tilong, Desa Oelnasi, Kec. Kupang Tengah, Kab. Kupang, Nusa Tenggara Timur, dan berlangsung selama delapan bulan. Materi yang digunakan dalam penelitian ini adalah semen sapi bali yang ditampung dari satu ekor sapi bali jantan berumur lima tahun milik Yayasan Williams dan Laura yang telah dilatih, memiliki performans yang baik, dan organ reproduksi normal. Pakan yang diberikan adalah hijauan berupa rumput dan legum dan pemberian konsentrat secukupnya (dedak padi dan jagung giling).and P5 : 9%, 21.25%, 17.56% and 19.30%. Result of statistical analysis showed that there were a significant effect (P<0.05) between treatment on motility, viability, MPU and TAU of spermatozoa of Bali cattle till the third day of storage. It can be concluded that the supplementation of guava filtrate 0.9% in dilution of coconut water 80% - egg yolk 20% had been able to maintain motility, viability, MPU and TAU of spermatozoa of Bali cattle till the third day of storage at 5oC.

scholarly journals Dupilumab Provides Rapid and Sustained Clinically Meaningful Responses in Adults with Moderate-to-severe Atopic Dermatitis

2021 ◽  
Author(s):  
Jonathan I. Silverberg ◽  
Eric L. Simpson ◽  
Mark Boguniewicz ◽  
Marjolein S. De Bruin-Weller ◽  
Peter Foley ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Controlled Trial ◽  
Life Quality ◽  
Composite Endpoint ◽  
Response To Treatment ◽  
Severe Atopic Dermatitis ◽  
Meaningful Improvement ◽  
Therapeutic Decisions

Optimal management of atopic dermatitis requires a comprehensive assessment of response to treatment in order to inform therapeutic decisions. In a real-world setting, successful response to atopic dermatitis treatment is measured by sustained improvements in signs, symptoms, and quality of life. Post-hoc analyses of a 1-year, randomized, double-blinded, placebo-controlled trial (NCT02260986) of dupilumab with concomitant topical corticosteroid in 421 adults with moderate-to-severe atopic dermatitis (of whom 315/106 received placebo/dupilumab) was performed to assess the proportion of responders to dupilumab through a multidimensional composite endpoint. At 6-months, 80.2% of dupilumab-treated vs 40.0% placebo patients (p < 0.0001) achieved improvement in signs (Eczema Area and Severity ≤ 7), symptoms (worst itch score ≤ 4) or quality of life (Dermatology Life Quality Index ≤5), representative of minimal/clear atopic dermatitis. All 3 endpoints, indicative of no/minimal atopic dermatitis, were achieved by 44.3% of dupilumab-treated vs 10.2% placebo patients (p < 0.0001) and sustained through one year. Dupilumab treatment provided sustained clinically meaningful improvement in signs, symptoms and quality of life in adults with moderate-to-severe atopic dermatitis.

scholarly journals Reciproc Blue x V-File: a study on the performance of two reciprocant instruments after third use

2021 ◽  
Vol 10 (15) ◽  
pp. e174101522849
Author(s):  
Anna Elisa Souza Simeão ◽  
Maria Clara Santos Silva ◽  
Edeilton Santana de Oliveira Júnior e Bezerra ◽  
Caio Cesar Souza ◽  
Adolfo de Matos de Carvalho ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Nickel Titanium ◽  
Endodontic Treatment ◽  
Root Canals ◽  
The Third ◽  
Significant Difference ◽  
Experienced Operator

Objective: The cleaning and shaping of root canals is undeniably a step of great importance for the success of endodontic treatment. With the aim of optimizing the time and quality of this step, numerous instruments of different materials and shapes have been developed over the years. One of these instruments was nickel-titanium files, which have greater flexibility and resistance, allowing a better prognosis for endodontic treatment. In this study, two endodontic files, Reciproc Blue and V-File, were compared with the aim of evaluating their performance after the third use. Materials and methods: 60 acrylic blocks wrapped with laminated paper and filled with Nankin ink were used. Instrumentation was performed with an endodontic engine, by an experienced operator. After instrumentation, the blocks were photographed so that the photographs were superimposed. Results: After statistical analysis, it was found that there was no significant difference in the performance of the two groups after the third use. Conclusion: There was no significant difference between the two studied groups, and both are safe for the preparation of curved canals, but it is necessary that the manufacturer's recommendation is followed, regarding the number of canals instrumented with the same file.

scholarly journals 3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

2013 ◽  
Vol 50 (2) ◽  
pp. 81-96 ◽  
Author(s):  
Luiz Gonzaga Coelho ◽  
Ismael Maguinilk ◽  
Schlioma Zaterka ◽  
José Miguel Parente ◽  
Maria do Carmo Friche Passos ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Consensus Conference ◽  
Significant Progress ◽  
Current Management ◽  
Quality Of Evidence ◽  
The Third ◽  
Evidence Strength ◽  
H Pylori

Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

scholarly journals Effectiveness of expiratory technique and induced sputum in obtaining good quality sputum from patients acutely hospitalized with suspected lower respiratory tract infection: a statistical analysis plan for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mariana Bichuette Cartuliares ◽  
Helene Skjøt-Arkil ◽  
Flemming Schønning Rosenvinge ◽  
Christian Backer Mogensen ◽  
Thor Aage Skovsted ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Statistical Analysis ◽  
Adverse Effects ◽  
Lower Respiratory Tract ◽  
Controlled Trial ◽  
Sputum Sample ◽  
Statistical Analysis Plan ◽  
Sputum Induction ◽  
Randomized Controlled

Abstract Background Targeted antimicrobial treatment is essential to avoid unnecessary use of broad-spectrum antibiotics and antimicrobial resistance. Targeted treatment relies on a precise microbiological diagnosis — in pneumonia, this poses a challenge as the usefulness of Gram stains and cultures is highly dependent on the quality of the sputum sample. This study aims to examine adverse effects and quality of sputum samples obtained by expiratory techniques (forced expiratory technique and sputum induction) compared with tracheal suction. The hypothesis is that expiratory techniques are non-inferior to tracheal suction in obtaining samples from the lower respiratory tract. This statistical analysis plan (SAP) describes the study design, method, and data analysis of the trial to increase transparency, avoid reporting bias or data-driven analysis and increase the study’s reproducibility. Method The design is a pragmatic, non-inferiority, parallel-arm randomized controlled trial including 280 patients admitted with suspected lower respiratory infection to two emergency departments. Patients are randomized to a usual care group, where sputum samples are collected by tracheal suction or to an intervention group where sputum samples are collected by forced expiratory technique and sputum induction. The statistical analysis will follow an intention-to-treat protocol. This SAP is developed and submitted before the end of recruitment, database closure, and statistical analyses. Discussion The results of this study will provide valuable knowledge to clinical practice by comparing adverse effects and sputum sample quality associated with different sample methods. Trial registration Clinicaltrials.gov, NCT04595526. Submitted on October 19, 2020

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