scholarly journals In dogs with chronic enteropathy that have hypocobalaminaemia, can oral tablets be used instead of injectable protocols?

2019 ◽  
Vol 4 (3) ◽  
Author(s):  
Avril McGinn
Keyword(s):  
Clinical Trials ◽  
Gastrointestinal Disease ◽  
Controlled Clinical Trials ◽  
Bottom Line ◽  
Oral Dosing ◽  
Future Studies ◽  
Chronic Enteropathy ◽  
Randomised Controlled

PICO question In dogs with chronic enteropathy does treatment with oral cobalamin compared to parenteral cobalamin provide serum cobalamin levels greater than 270 ng/L? Clinical bottom line The evidence provided by block randomised controlled clinical trials indicates that oral dosing of cobalamin results in normocobalaminaemia, with levels similar to that achieved with parenteral dosing. These studies provide veterinary professionals with dosing schedules, and monitoring serum cobalamin levels is recommended to ensure normocobalaminaemia is achieved. It has been shown that supplementation with both oral and parenteral cobalamin correlates with increased intracellular cobalamin levels. Future studies are needed to investigate the outcome of oral cobalamin dosing in dogs with extra-gastrointestinal disease.  

scholarly journals Thrombolytic Therapy in the Acute Period of Aortic Thromboembolism in Cats

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Joshua Billy Hannabuss
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Open Access ◽  
Thrombolytic Therapy ◽  
Acute Phase ◽  
Large Scale ◽  
Supportive Therapy ◽  
Controlled Clinical Trials ◽  
Bottom Line ◽  
Adverse Side Effects

<strong>PICO question</strong><br /><p>Of cats that present with aortic thromboembolism, do patients that receive thrombolytic therapy in the acute phase have improved survival as compared to those who do not?</p><strong>Clinical bottom line</strong><br /><p>Based on the current available evidence, the use of thrombolytic therapy in the acute phase of aortic thromboembolism (ATE) does not appear to improve survival when compared to conventional supportive therapy. Frequently reported adverse side effects further questions its merits, and large scale controlled clinical trials would be required to further evaluate any benefit in the use of this therapy.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

Longitudinal stent deformation: quantitative coronary angiographic analysis from the PERSEUS and PLATINUM randomised controlled clinical trials

2012 ◽  
Vol 8 (2) ◽  
pp. 187-195 ◽  
Author(s):  
Dean J. Kereiakes ◽  
Jeffrey J. Popma ◽  
Louis A. Cannon ◽  
David E. Kandzari ◽  
Carey D. Kimmelstiel ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Controlled Clinical Trials ◽  
Stent Deformation ◽  
Randomised Controlled

Advances in Periodontology

2000 ◽  
Vol os7 (4) ◽  
pp. 149-152 ◽  
Author(s):  
Maurizio S Tonetti
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Periodontal Diseases ◽  
Evidence Based ◽  
Controlled Clinical Trials ◽  
Soft Tissue Management ◽  
Research Findings ◽  
Randomised Controlled ◽  
Periodontal Plastic Surgery ◽  
Implant Treatment

Advances in periodontal science and practice over the last decade have radically changed the understanding of periodontal diseases and have opened new, exciting prospects for both medical and surgical therapy of periodontal diseases. Establishment of the aetiology and pathogenesis of periodontitis, understanding of the unique genetic and environmental susceptibility profile of affected subjects, and recognition of the systemic implications of periodontal infections are the key research findings. The use of randomised, controlled, clinical trials has allowed the development of evidence-based periodontology. Adjunctive antimicrobial therapy, regenerative periodontal surgery, periodontal plastic surgery, bone regeneration surgery in the light of implant treatment, and advanced soft tissue management at implant sites have radically changed practice.

PP15 Consent as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review

2017 ◽  
Vol 34 (10) ◽  
pp. e5.2-e5
Author(s):  
Stephanie Armstrong ◽  
Adele Langlois ◽  
Despina Laparidou ◽  
Mark Dixon ◽  
Jason P Appleton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Ethical Consideration ◽  
Controlled Clinical Trials ◽  
Randomised Controlled
Sign in / Sign up

Export Citation Format

Share Document