Evaluation of bone metabolism in obese men and women with metabolic syndrome

2016 ◽  
Vol 70 ◽  
pp. 133-142
Author(s):  
Magdalena Titz-Bober ◽  
Michał Holecki ◽  
Anna Hawrot-Kawecka ◽  
Magdalena Olszanecka-Glinianowicz ◽  
Jerzy Chudek ◽  
...  
2011 ◽  
Vol 9 (6) ◽  
pp. 647-657 ◽  
Author(s):  
Vassilios G. Athyros ◽  
Emmanouel Ganotakis ◽  
Genovefa D. Kolovou ◽  
Vassilios Nicolaou ◽  
Apostolos Achimastos ◽  
...  

2009 ◽  
Vol 31 (5) ◽  
pp. 602-613 ◽  
Author(s):  
A. Scuteri ◽  
S. S. Najjar ◽  
M. Orru' ◽  
G. Usala ◽  
M. G. Piras ◽  
...  

2009 ◽  
Vol 35 (2) ◽  
pp. 143-150 ◽  
Author(s):  
M.K. Salonen ◽  
E. Kajantie ◽  
C. Osmond ◽  
T. Forsén ◽  
H. Ylihärsilä ◽  
...  

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1663 ◽  
Author(s):  
Zhenni Zhu ◽  
Fan Wu ◽  
Ye Lu ◽  
Chunfeng Wu ◽  
Zhengyuan Wang ◽  
...  

The causal relationship between serum ferritin and metabolic syndrome (MetS) remains inconclusive. Dietary iron intake increases serum ferritin. The objective of this study was to evaluate associations of total, heme, and nonheme dietary iron intake with MetS and its components in men and women in metropolitan China. Data from 3099 participants in the Shanghai Diet and Health Survey (SDHS) obtained during 2012–2013 were included in this analysis. Dietary intake was assessed by 24-h diet records from 3 consecutive days. Multivariate generalized linear mixed models were used to evaluate the associations of dietary iron intake with MetS and its components. After adjustment for potential confounders as age, sex, income, physical exercise, smoking status, alcohol use, and energy intake, a positive trend was observed across quartiles of total iron intake and risk of MetS (p for trend = 0.022). Compared with the lowest quartile of total iron intake (<12.72 mg/day), the highest quartile (≥21.88 mg/day) had an odds ratio (95% confidence interval), OR (95% CI), of 1.59 (1.15,2.20). In addition, the highest quartile of nonheme iron intake (≥20.10 mg/day) had a 1.44-fold higher risk of MetS compared with the lowest quartile (<11.62 mg/day), and higher risks of MetS components were associated with the third quartiles of total and nonheme iron intake. There was no association between heme iron intake and risk of MetS (p for trend = 0.895). Associations for total and nonheme iron intake with MetS risk were found in men but not in women. Total and nonheme dietary iron intake was found to be positively associated with MetS and its components in the adult population in metropolitan China. This research also revealed a gender difference in the association between dietary iron intake and MetS.


2005 ◽  
Vol 98 (1) ◽  
pp. 168-179 ◽  
Author(s):  
Dustin S. Hittel ◽  
William E. Kraus ◽  
Chuck J. Tanner ◽  
Joseph A. Houmard ◽  
Eric P. Hoffman

Aerobic conditioned muscle shows increased oxidative metabolism or glucose relative to untrained muscle at a given absolute exercise intensity. The studies of a targeted risk reduction intervention through defined exercise (STRRIDE) study is an aerobic exercise intervention in men and women with features of metabolic syndrome (Kraus WE, Torgan CE, Duscha BD, Norris J, Brown SA, Cobb FR, Bales CW, Annex BH, Samsa GP, Houmard JA, and Slentz CA, Med Sci Sports Exerc 33: 1774–1784, 2001), with four muscle biopsies taken during training and detraining time points. Here, we expanded a previous study (Hittel DS, Kraus WE, and Hoffman EP, J Physiol 548: 401–410, 2003) and used mRNA profiling to investigate gene transcripts associated with energy and substrate metabolism in STRRIDE participants. We found coordinate regulation of key metabolic enzymes with aerobic training in metabolic syndrome (aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1). All were also quickly downregulated by detraining, although the induction was not an acute response to activity. Protein and enzymatic assays were used to validate mRNA induction with aerobic training and loss with detraining (96 h to 2 wk) in 10 male and 10 female STRRIDE subjects. We propose that training coordinately increases the levels of aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1 subunit, increasing glucose metabolism in muscle by liberating pyruvate for oxidative metabolism and, therefore, limiting lactate efflux. Serial measurement of fasting plasma lactate from 62 subjects from the same exercise group demonstrated a significant decrease of circulating lactate with training. We also found evidence for sex-specific molecular remodeling of muscle with ubiquinol-cytochrome c reductase core protein II, a component of mitochondrial respiratory complex III, which showed an increase after training that was specific to women. These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals.


2019 ◽  
Vol 34 (3) ◽  
pp. 463-471
Author(s):  
Anouk E. Wit ◽  
Erik J. Giltay ◽  
Marrit K. Boer ◽  
Fokko J. Bosker ◽  
Roos C. Mast ◽  
...  

2019 ◽  
Vol 1 (9) ◽  
pp. 535-541 ◽  
Author(s):  
B. Kuriya ◽  
O. Schieir ◽  
M. F. Valois ◽  
J. E. Pope ◽  
G. Boire ◽  
...  

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Catherine J Andersen ◽  
Christopher N Blesso ◽  
Youngki Park ◽  
Jacqueline Barona ◽  
Tho Pham ◽  
...  

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