scholarly journals Recombinant short TNF-BD protein from smallpox virus is pharmacologically active in an experimental septic shock model

2020 ◽  
Vol 24 (3) ◽  
pp. 239-243
Author(s):  
I. P. Gileva ◽  
S. N. Yakubitskiy ◽  
I. V. Kolosova ◽  
S. N. Shchelkunov
Keyword(s):  
Septic Shock ◽  
Shock Model ◽  
Smallpox Virus ◽  
Experimental Septic Shock ◽  
Pharmacologically Active

The effects of milrinone on hemodynamics in an experimental septic shock model

2005 ◽  
Vol 6 (2) ◽  
pp. 195-199 ◽  
Author(s):  
Jean-Michel Liet ◽  
C??dric Jacqueline ◽  
Jean-Luc Orsonneau ◽  
Christ??le Gras-LeGuen ◽  
Gilles Potel ◽  
...  
Keyword(s):  
Septic Shock ◽  
Shock Model ◽  
Experimental Septic Shock

Alteration of macrophage activity in experimental septic shock in the rabbit

1991 ◽  
Vol 99 (1) ◽  
pp. 61-65
Author(s):  
S. Schneebaum ◽  
E. Klein ◽  
J. H. Passwell ◽  
M. Modan ◽  
N. Kariv ◽  
...  
Keyword(s):  
Septic Shock ◽  
Macrophage Activity ◽  
Experimental Septic Shock

scholarly journals Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Heng Zhang ◽  
Yini Sun ◽  
Xin An ◽  
Xiaochun Ma
Keyword(s):  
Septic Shock ◽  
Unfractionated Heparin ◽  
Flow Index ◽  
Shock Model ◽  
Microcirculatory Perfusion ◽  
Basic Therapy ◽  
E Coli ◽  
Intestinal Microcirculation ◽  
Hemodynamic Variables ◽  
Lactate Levels

Background. Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfusion and systemic circulation in a septic shock model. Methods. Twenty-four beagle dogs were randomly allocated into four groups: (a) sham group: healthy controls, (b) shock group: septic shock induced by Escherichia coli, (c) basic therapy group: septic shock animals treated with antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals treated with basic therapy plus UFH. Hemodynamic variables were measured within 24 h after E. coli administration. The intestinal microcirculation was simultaneously investigated with a sidestream dark-field imaging technique. Additionally, the function of vital organs was evaluated at 12 h postadministration (T12). Results. E. coli induced a progressive septic shock in which the mean arterial pressure (MAP) decreased and lactate levels sharply increased, accompanied by deteriorated microvessel perfusion. While basic therapy partially improved the microvascular flow index and the perfused microvessel density in the jejunal villi, UFH significantly restored major microcirculation variables at T12. Physiological variables, including MAP, urine output, and lactate levels, were improved by UFH, whereas some hemodynamic indices were not affected by UFH. With respect to organ function, UFH increased the platelet count and decreased the creatinine level. Conclusions. UFH improves microcirculatory perfusion of the small intestine independently of the changes in systemic hemodynamic variables in a canine model of septic shock, thereby improving coagulation and renal function.

Benefits Of Ethyl -Gallate Vs Norepinephrine On Hemodynamics In Experimental Septic Shock In Dogs

2011 ◽  
Author(s):  
Jose Gotes Palazuelos ◽  
Hans Jacobs ◽  
Krika Kasian ◽  
Zhao-Qin Cheng ◽  
Steven N. Mink
Keyword(s):  
Septic Shock ◽  
Ethyl Gallate ◽  
Experimental Septic Shock

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock

2014 ◽  
Vol 460 (2) ◽  
pp. 309-316 ◽  
Author(s):  
Zhen Wang ◽  
Simon Lambden ◽  
Valerie Taylor ◽  
Elizabeth Sujkovic ◽  
Manasi Nandi ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cell Function ◽  
Immune Cell ◽  
Cardiovascular Function ◽  
Rodent Model ◽  
Morbidity And Mortality ◽  
Immune Cell Function ◽  
Organ Function ◽  
Experimental Septic Shock ◽  
First Time

The present study shows for the first time in the most relevant possible rodent model of shock that the DDAH1 inhibitor L-257 improves morbidity and mortality in septic shock by improving cardiovascular function without impairing the immune cell function.

A New Approach to the Treatment of Experimental Septic Shock

1996 ◽  
Vol 61 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Robert M. Hardaway ◽  
Charles H. Williams ◽  
Yang Sun
Keyword(s):  
Septic Shock ◽  
New Approach ◽  
Experimental Septic Shock

Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model

2006 ◽  
Vol 34 (5) ◽  
pp. 1483-1488 ◽  
Author(s):  
Gernot Marx ◽  
Tobias Schuerholz ◽  
Samantha Pedder ◽  
Tim Simon ◽  
Stephen Grime ◽  
...  
Keyword(s):  
Septic Shock ◽  
Monitoring System ◽  
Blood Volume ◽  
Shock Model ◽  
Volume Measurements

Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model

1994 ◽  
Vol 424 (6) ◽  
Author(s):  
S. Hauptmann ◽  
B. Klosterhalfen ◽  
J. Weis ◽  
C. Mittermayer ◽  
C.J. Kirkpatrick
Keyword(s):  
Skeletal Muscle ◽  
Septic Shock ◽  
Muscle Fibre ◽  
Shock Model
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