scholarly journals Expression of genes of cytokines, transcription factors and differentiation antigens in human dendritic cells activated by double-stranded DNA

2017 ◽  
Vol 21 (6) ◽  
pp. 717-727 ◽  
Author(s):  
A. S. Proskurina ◽  
K. E. Orishchenko ◽  
E. A. Potter ◽  
E. V. Dolgova ◽  
A. V. Spaselnikova ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Transcription Factors ◽  
Differentiation Antigens ◽  
Double Stranded Dna ◽  
Expression Of Genes ◽  
Human Dendritic Cells

Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity

2010 ◽  
Vol 262 (2) ◽  
pp. 120-126 ◽  
Author(s):  
Ekaterina A. Alyamkina ◽  
Evgenia V. Dolgova ◽  
Anastasia S. Likhacheva ◽  
Vladimir A. Rogachev ◽  
Tamara E. Sebeleva ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Double Stranded Dna ◽  
Human Dendritic Cells

The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review

2021 ◽  
Vol 20 ◽  
Author(s):  
Rabih Roufayel ◽  
Rabih Mezher ◽  
Kenneth B. Storey
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Cell Cycle Control ◽  
Expression Of Genes ◽  
E2f Transcription Factor ◽  
Cellular Energetics ◽  
Development And Differentiation ◽  
E2f Transcription Factors ◽  
Rb Phosphorylation

: Selected transcription factors have critical roles to play in organism survival by regulating the expression of genes that control the adaptations needed to handle stress conditions. The retinoblastoma (Rb) protein coupled with the E2F transcription factor family was demonstrated to have roles in controlling the cell cycle during freezing and associated environmental stresses (anoxia, dehydration). Rb phosphorylation or acetylation at different sites provide a mechanism for repressing cell proliferation that is under the control of E2F transcription factors in animals facing stresses that disrupt cellular energetics or cell volume controls. Other central regulators of the cell cycle including Cyclins, Cyclin dependent kinases (Cdks), and checkpoint proteins detect DNA damage or any improper replication, blocking further progression of cell cycle and interrupting cell proliferation. This review provides an insight into the molecular regulatory mechanisms of cell cycle control, focusing on Rb-E2F along with Cyclin-Cdk complexes typically involved in development and differentiation that need to be regulated in order to survive extreme cellular stress.

scholarly journals Development and function of human dendritic cells in humanized mice models

2020 ◽  
Vol 125 ◽  
pp. 151-161
Author(s):  
Giorgio Anselmi ◽  
Julie Helft ◽  
Pierre Guermonprez
Keyword(s):  
Dendritic Cells ◽  
Humanized Mice ◽  
And Function ◽  
Human Dendritic Cells
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