Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation

Introduction: Peripheral and central nervous system inflammation have been linked to the classic symptoms of Parkinson’s disease (PD) and Alzheimer’s disease (AD). However, it remains unclear whether the analysis of routine systemic inflammatory markers could represent a useful prediction tool to identify clinical subtypes in patients with Parkinson’s and Alzheimer’s at higher risk of dementia-associated symptoms, such as behavioral and psychological symptoms of dementia (BPSD). Methods: We performed a multivariate logistic regression using the 2016 and 2017 National Inpatient Sample with International Classification of Diseases 10th edition codes to assess if pro-inflammatory white blood cells (WBCs) anomalies correlate with dementia and BPSD in patients with these disorders. Results: We found that leukocytosis was the most common WBC inflammatory marker identified in 3.9% of Alzheimer’s and 3.3% Parkinson’s patients. Leukocytosis was also found to be an independent risk factor for Parkinson’s dementia. Multivariate analysis of both cohorts showed that leukocytosis is significantly decreased in patients with BPSD compared to patients without BPSD. Conclusions: These results suggest a link between leukocytosis and the pathophysiology of cognitive dysfunction in both PD and AD. A better understanding of the role of systemic neuroinflammation on these devastating neurodegenerative disorders may facilitate the development of cost-effective blood biomarkers for patient’s early diagnosis and more accurate prognosis.

Download Full-text

The Role of Flexibility in the Realization of Inclusive Education

Sustainability ◽

10.3390/su13084452 ◽

2021 ◽

Vol 13 (8) ◽

pp. 4452

Author(s):

Laura Lübke ◽

Martin Pinquart ◽

Malte Schwinger

Keyword(s):

Social Skills ◽

Inclusive Education ◽

Learning Difficulties ◽

Social Benefits ◽

Direct Effects ◽

Behavioral Disturbances ◽

Teachers Attitudes ◽

And Behavior ◽

Mainstream Students

This study focused on associations between teachers’ flexibility and their use of evidence-based strategies in inclusive education in a sample of N = 119 teachers. Flexibility showed direct effects on teachers’ attitudes towards the achievement of mainstream students and students with learning difficulties, attitudes towards social benefits of inclusion for students with emotional and behavioral disturbances, and on teachers’ self-efficacy regarding the support of students’ social skills. Furthermore, indirect effects of flexibility on intentions and behavior regarding the support of social skills were found. The findings emphasize the importance of teachers’ flexibility in the realization of inclusive education.

Download Full-text

Non-random associations in group housed rats (Rattus norvegicus)

Scientific Reports ◽

10.1038/s41598-021-94608-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Leanne Proops ◽

Camille A. Troisi ◽

Tanja K. Kleinhappel ◽

Teresa Romero

Keyword(s):

Network Analysis ◽

Empirical Evidence ◽

Rattus Norvegicus ◽

Dominance Hierarchy ◽

Group Living ◽

Ecological Factors ◽

Limited Evidence ◽

Rat Strains ◽

Social Species ◽

Over Time

AbstractEcological factors, such as predation, have traditionally been used to explain sociability. However, it is increasingly recognised that individuals within a group do not associate randomly, and that these non-random associations can generate fitness advantages. The majority of the empirical evidence on differentiated associations in group-living mammals, however, comes from a limited number of taxa and we still know very little about their occurrence and characteristics in some highly social species, such as rats (Rattus spp.). Here, using network analysis, we quantified association patterns in four groups of male fancy rats. We found that the associations between rats were not randomly distributed and that most individuals had significantly more preferred/avoided associates than expected by random. We also found that these preferences can be stable over time, and that they were not influenced by individuals’ rank position in the dominance hierarchy. Our findings are consistent with work in other mammals, but contrast with the limited evidence available for other rat strains. While further studies in groups with different demographic composition are warranted to confirm our findings, the occurrence of differentiated associations in all male groups of rats have important implications for the management and welfare of captive rat populations.

Download Full-text

THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽

10.1093/genetics/100.1.79 ◽

1982 ◽

Vol 100 (1) ◽

pp. 79-87

Author(s):

Daniel W Nebert ◽

Nancy M Jensen ◽

Hisashi Shinozuka ◽

Heinz W Kunz ◽

Thomas J Gill

Keyword(s):

Specific Activity ◽

Inbred Mouse ◽

Inbred Mouse Strain ◽

Mouse Strains ◽

Ah Receptor ◽

Inbred Mouse Strains ◽

Sprague Dawley ◽

Rat Strains ◽

Specific Activities ◽

Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

Download Full-text