scholarly journals Clinical Study of Urinary Kallidinogenase in the Treatment of Progressive Cerebral Infarction

2013 ◽  
Vol 2 ◽  
pp. 13
Author(s):  
Binghui Fan ◽  
Weidong Li
Keyword(s):  
Treatment Group ◽  
Cerebral Infarction ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Neurological Impairment ◽  
Effective Rate ◽  
Control Group ◽  
Before And After ◽  
And Control ◽  
Better Than

<p><strong>Objective: </strong>To evaluate the efficacy and safety of Urinary kallidinogenase in the treatment of progressive cerebral infarction. <strong>Method: </strong>104 cases of patients with acute cerebral infarction were randomly divided into treatment group and control group; where control group (52 cases) patients on with only basic medicine, while treatment group (52 cases), besides the basic medicine, patients will on urinary kallidinogenase 0.15 PNAU + 0.9% normal saline 100 mL intravenous injection, 1 times per day, and continuous for 14 days. The degree of neurological impairment (NIHSS) was assessed before and after treatment, and the changes of blood pressure were monitored. The liver, renal function, fibrinogen, platelet, and the adverse reactions were recorded and followed up in three month. <strong>Results</strong><strong>: </strong>After treatment, NIHSS scores of the both groups were decreased (<em>p</em> &lt; 0.05), however, total effective rate for treatment group were better than control group (<em>p</em> &lt; 0.05). <strong>Conclusion: </strong>Urinary kallidinogenase is safe and effective in the treatment of progressive cerebral infarction.</p>

scholarly journals Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

2013 ◽  
Vol 2 ◽  
pp. 7
Author(s):  
Li Liu
Keyword(s):  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
And Control ◽  
Group Observation

<p><strong>Objective: </strong>To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. <strong>Method: </strong>From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. <strong>Results: </strong>The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, <em>p</em> &lt; 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. <strong>Conclusion: </strong>Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.</p>

scholarly journals Apatinib, S-1 Combined with Paclitaxel Perfusion in the Treatment of Malignant Seroperitoneum of Gastric Cancer

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Zhiyu Wang ◽  
Dan Hong ◽  
Zhuoqi Zhang ◽  
Shenyong Su ◽  
Yan Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Treatment Effect ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Good Prognosis ◽  
Control Group ◽  
Observation Group ◽  
And Control

Objective: To analyze the effect of apatinib, S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer. Methods: From December 2019 to May 2020, 172 patients with gastric cancer treated in our hospital were randomly divided into two groups: observation group and control group, 86 cases each. The control group adopted the method of S-1 combined with paclitaxel perfusion therapy in the treatment of malignant seroperitoneum of gastric cancer. The observation group was given oral apatinib on the basis of S-1 combined with paclitaxel perfusion therapy, and the dosage was 500 mg/d. Results: The total effective rate of treatment in the control group was 43.02%, while the total effective rate in the observation group was 69.77%; the drug resistance of the two groups of patients increased and the adverse reactions were low. Conclusion: Apatinib and S-1 combined with paclitaxel perfusion therapy can effectively improve the treatment effect, stabilize the patient's condition, increase the patient's drug resistance to adverse reactions, and have a good prognosis.

scholarly journals Treatment of Non-erosive Effect of Clinical Study of Gastroesophageal Reflux Disease

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Qian Liu
Keyword(s):  
Treatment Group ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
And Control

<p class="18">Abstract: Objective: To observe the clinical effect of “Chaihu Shugan Powder Zuojin Pill” in the treatment of non-erosive gastroesophageal reflux disease. Methods: Sixty patients with non-erosive gastroesophageal reflux disease were randomly divided into treatment group and control group (30 cases in each group). The patients were treated with “Zaohu Shugan Powder” and “Zangjin Pills” and omeprazole respectively. For 8 weeks, the clinical efficacy and changes in clinical symptoms were observed. Results: The total effective rate was 93.3% in the treatment group and 80.0% in the control group. There was significant difference between the two groups before and after treatment (P &lt;0.05). Conclusion: “Chaihu Shugan Powder Zuojin Pill” can effectively improve the clinical symptoms of non-erosive gastroesophageal reflux disease.</p>

Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings

2021 ◽  
pp. 1-5
Author(s):  
Pan Huang ◽  
Xiao-ying He ◽  
Min Xu
Keyword(s):  
Treatment Group ◽  
Cerebral Infarction ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
National Institutes Of Health ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Scale Scores ◽  
The Difference ◽  
And Control

<b><i>Objective:</i></b> The aim is to observe the effects of argatroban injection and butylphthalide injection on blood flow rheology, clinical efficacy, and safety in patients with acute cerebral infarction. <b><i>Methods:</i></b> 344 patients with acute cerebral infarction within 48 h after admission were divided into treatment group and control group, with 172 cases in each group. The control group received routine treatment. The treatment group received argatroban injection 60 mg on the basis of the control group, intravenously guttae (ivgtt) was used for 2 days and then changed to argatroban injection 10 mg, ivgtt bid for 5 days, and the total course of treatment was 7 days. The neurological changes, activities of daily living, and the rheology indicators (fibrinogen [Fib], platelet aggregation rate [Pag], whole blood high shear viscosity [Whsv], hematocrit [Hct]) were compared between the 2 groups, clinical efficacy and adverse drug reactions. <b><i>Results:</i></b> After treatment, the total effective rates of the treatment group and the control group were 90.70% (156 /172 cases) and 74.41% (128 and 172 cases), respectively, and the difference was statistically significant (<i>p</i> &#x3c; 0.05). After treatment, the National Institutes of Health Stroke Scale scores of the treatment group and the control group were (7.05 ± 1.97) and (8.30 ± 1.79), respectively, and the Barthel index was (68.02 ± 11.07) and (62.32 ± 11.46), respectively. The difference was statistically significant (<i>p</i> &#x3c; 0.05). After treatment, the treatment group and the control group were (2.66 ± 0.22) g/L and (3.50 ± 0.22) g/L, respectively, and Pag were (0.68 ± 0.06)% and (0.81 ± 0.09)%, respectively, and Whsv was (6.44 ± 0.76) mPs/s and (6.87 ± 0.91) mPs/s, Hct were (8.19 ± 1.21)% and (10.44 ± 1.04)%, respectively, and the differences were statistically significant (<i>p</i> &#x3c; 0.05). The incidence of adverse reactions in the treatment group and the control group was 6.97 and 5.81%, respectively, and the difference was not statistically significant (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> Argatroban injection is effective in the treatment of acute cerebral infarction, which can significantly improve the hemorheology of patients with good safety.

scholarly journals Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Xuewen Wo ◽  
Jinyan Han ◽  
Jiajia Wang ◽  
Xinmin Wang ◽  
Xiaoying Liu ◽  
...  
Keyword(s):  
Plasma Level ◽  
Cerebral Infarction ◽  
Antiplatelet Therapy ◽  
Adverse Reactions ◽  
Dual Antiplatelet Therapy ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Observation Group ◽  
Significant Difference ◽  
Better Than

Objective: To observe the clinical efficacy of sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of elderly patients with acute cerebral infarction (ACI). Methods: One hundred and twenty-two elderly patients with ACI who were admitted to the department of neurology of our hospital at May 2016-August 2018 were selected grouped into a control group and an observation group by random number table method, 61 in each group. On the basis of conventional treatment, the patients in the control group were given dual antiplatelet therapy (aspirin enteric-coated tablets + clopidogrel bisulfate tablets), while the patients in the observation group were given sequential butylphthalide therapy on the basis of the control group. The clinical effects of the two groups were compared after four weeks of treatment, and the changes of National Institutes of Health Stroke Scale (NIHSS), ADL score, plasma 3-mercaptopyruvate sulphurtransferase (3-MST) and Amyloid β42 (Aβ42) levels and the occurrence of adverse reactions during treatment were recorded. Results: The clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no significant difference in NIHSS and ADL scores between the two groups before treatment (P>0.05). After treatment, the NIHSS and ADL scores of the observation group were better than those of the control group (P<0.05). There was no significant difference in plasma levels of 3-MST and AB42 between the two groups before treatment (P>0.05). The level of plasma 3-MST in the observation group was higher than that in the control group, and the level of plasma Aβ42 was lower than that in the control group (P<0.05). No serious adverse reactions occurred during the treatment period in both groups. Conclusion: Butylphthalide sequential therapy combined with dual antiplatelet therapy is effective in the treatment of elderly ACI. It can effectively improve the plasma level of 3-MST and decrease the plasma level of Aβ42, which is conducive to improving the living ability and neurological function of patients and has high safety. doi: https://doi.org/10.12669/pjms.36.4.1831 How to cite this:Wo X, Han J, Wang J, Wang X, Liu X, Wang Z. Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1831 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals PERBEDAAN PENURUNAN TEKANAN DARAH PRA LANSIA PRE HIPERTENSI YANG DIBERI JUS TOMAT (Lycopersicum grandifilum)

2018 ◽  
Vol 10 (2) ◽  
pp. 152-158
Author(s):  
Hari Yani Fadillah
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Block Design ◽  
Pressure Control ◽  
Tomato Juice ◽  
Control Group ◽  
Randomized Block Design ◽  
Before And After ◽  
Blood Pressure Treatment ◽  
And Control

The research aims to know the effect of tomato juice on blood pressure in pre-elderly pre hypertension at Posbindu Puskesmas Nusa Indah Bengkulu City.The design of research was a quasi experiment include pre test post test. This population was all patients posbindu aged 45-59 years. Sampling of this research randomized block design of one factorial were 6 samples divided into treatment and control group. The data which have been analyzed using univariate and bivariate. From this research were obtained the results such as the mean of sistole blood pressure before and after intervention in treatment group p = 0,273 and diastole p = 0,27. Mean systole blood pressure control group p = 0.060 and diastole p = 2.14. Distribution of tomato juice (Lycopersicum grandifilum) did not given affect the decrease in blood pressure of systole diastole before and after intervention in pre-elderly pre hypertension. Whereas the difference in mean systole of blood pressure treatment and control group p = 0.935 and diastolic of blood pressure p = 0.678. There ware not difference in mean of blood pressure in the tomato juice treatment group and control of Vitamin C. The result concluded there were not effect of tomato juice (Lycopersicum grandifilum) on systolic of blood pressure in pre-elderly pre hypertension at Posbindu Puskesmas Nusa Indah Bengkulu City.

scholarly journals Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Liao Wu ◽  
Ying Sun ◽  
Guihua Ni ◽  
Bo Sun ◽  
Xiaoyu Ni ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Neurological Deficit ◽  
Daily Living ◽  
Adverse Reactions ◽  
Neurological Impairment ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Nihss Score ◽  
Cerebral Hemodynamic ◽  
Life Function

Objective. This research aimed at investigating the efficacy of edaravone combined with clopidogrel on acute cerebral infarction (ACI) and its influence on the neurological deficit and life function. Methods. Totally, 154 ACI cases were included and then divided into the control group (CG) (n = 71) and research group (RG) (n = 83) according to the treatment methods. Patients in the CG were treated with clopidogrel alone, and those in the RG were under edaravone-clopidogrel combination therapy. The efficacy, adverse reactions, NIHSS score, cerebral hemodynamic indexes, and Fugl-Meyer scale (FMA) and Barthel index (BI) of activities of daily living (ADL) scores were observed. Results. Compared with before treatment, the symptoms of both groups were improved after treatment: the NIHSS scores decreased, FMA and ADL scores increased, and cerebral hemodynamic indexes were improved. Compared with the CG, the efficacy and cerebral hemodynamic indexes of the RG were better, the adverse reactions were equivalent, the NIHSS score was lower, and the ADL and FMA scores were higher. Conclusion. Edaravone combined with clopidogrel can effectively treat ACI and improve the neurological deficit and life function of patients.

scholarly journals The Effect of Occupatioal Therapy on Social Skill in Schizofrenia with Social Isolation

2014 ◽  
Vol 1 (2) ◽  
pp. 081-086
Author(s):  
Rendra Sukmana ◽  
Nawang Wulandari
Keyword(s):  
Social Skills ◽  
Treatment Group ◽  
Occupational Therapy ◽  
Social Isolation ◽  
Rank Test ◽  
Control Group ◽  
Before And After ◽  
Physical Disorders ◽  
Social Capability ◽  
And Control

Occupational therapy is a healing effort against someone who is experiencing mental and physical disorders by giving liveliness job. The purpose of the study to determine the effect of Occupational Therapy on social skills in schizophrenia with social isolation, using Quasy Control Group Pre-test Posttest Design. Sampel used in this experiments were 10 respondents that are divided into 2 groups: treatment and control. The treatment group was given occupational therapy 2 times a week for 3 weeks. Observations by 12 questions was conducted to determine the level of social skills of respondents. The results of this study showed no increase on the level of social skills before and after given granted Occupational Therapy. The level of social capability of 5 respondents in the treatment group before given an Occupational Therapy were 7 and while after given an occupational therapy were 10.2. This result have contrast to the control group which showed level of social capability were 7 . Statistic Analized using Wilcoxon Sign Rank Test showed significant is 0.0205 in the group between pre and post treatment, while the treatment and control group comparisons with Mann Whitney U test showed 0.029 ≤ 0.05. With these results Occupational Therapy can improve social skills clients with social isolation.

Arthroscopic Debridement Combined with Rehabilitation Training in the Treatment of Knee Osteoarthritis

2021 ◽  
Vol 7 (5) ◽  
pp. 3384-3388
Author(s):  
Wei Sun ◽  
Wenjie Yu ◽  
Yanhua Wang ◽  
Guangliang Hu
Keyword(s):  
Knee Osteoarthritis ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Arthroscopic Debridement ◽  
Rehabilitation Training ◽  
The Difference ◽  
Score Result ◽  
Better Than

Objective: The clinical effect of arthroscopic debridement combined with rehabilitation training in the treatment of knee arthritis was studied and analyzed. Methods: A total of 90 patients with knee osteoarthritis treated in our hospital from August 2017 to August 2018 were selected as the research objects. All patients were divided into the observation group and the control group by using the random number method. The control group was treated by arthroscopic cleaning operation, and the observation group was treated by combined rehabilitation training on the basis of the treatment in the control group. The total effective rate and simple McGill pain of the two groups were compared Score and lyshoim score. Result: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the difference was statistically significant; after treatment, the simple McGill pain score of the observation group was significantly lower than that of the control group (P < 0.05), the difference was statistically significant, the lyshoim score of the observation group was significantly better than that of the control group (P < 0.05), the difference was statistically significant. Conclusion: In the treatment of knee osteoarthritis, arthroscopic debridement combined with rehabilitation training has a significant effect, which can significantly reduce the pain and improve the prognosis of patients. It is worth popularizing in clinical treatment.

scholarly journals Pengaruh suplementasi Zn terhadap perubahan indeks TB/U anak stunted usia 24-36 bulan

2017 ◽  
Vol 5 (2) ◽  
pp. 98-104
Author(s):  
Dewi Pertiwi Dyah Kusudaryati ◽  
Siti Fatimah Muis ◽  
Laksmi Widajanti
Keyword(s):  
Treatment Group ◽  
Dietary Intake ◽  
Child Growth ◽  
Control Group ◽  
Control Group Design ◽  
Dietary Allowance ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
Height For Age

Background : Zn supplementation on stunted children in multiple research get the result inconsistent concerning the effect of Zn on children’s growth.Objective : To examine the effect of Zn supplementation to the change in height for index among stunted children age between 24-36 months.Methods: The research design is randomized pretest posttest control group design. The total of thirty six stunted children are divided into two groups. The treatment group is received syrup with 20 mg ZnSO4 twice a week for three months. The control group received placebo without Zn. Height for age z score (HAZ) on WHO Child Growth 2006 is used to measure height for age index while dietary intake and infection diseases are used as confounding variables.Result : There is significant difference in HAZ before and after supplementation at treatment group (p<0.001) and control group (p<0.001). There is a significant difference of the change in HAZ between the treatment group and control group (p=0.006). Percentage Achievement of Energy, Protein, and Zn Dietary Allowance have significant difference between the treatment group and control group (p=0.009; p<0.001; p<0.001, respectively). The change in HAZ, Percentage Achievement of Energy, Protein, and Zn Dietary Allowance are higher in treatment group than control group. Duration of diarrhea (p=0.045) and morbidity (p=0.019) are lower in treatment group than control group. Conclusion : Zn Supplementation among stunted children have significant effect on the change in HAZ, dietary intake, and infection.

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