scholarly journals Prostate cancer and the unfolded protein response

Oncotarget ◽  
2016 ◽  
Vol 7 (33) ◽  
pp. 54051-54066 ◽  
Author(s):  
Margrethe Storm ◽  
Xia Sheng ◽  
Yke Jildouw Arnoldussen ◽  
Fahri Saatcioglu
Keyword(s):  
Prostate Cancer ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals A Peptidic Unconjugated GRP78/BiP Ligand Modulates the Unfolded Protein Response and Induces Prostate Cancer Cell Death

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e45690 ◽  
Author(s):  
Danilo Maddalo ◽  
Antje Neeb ◽  
Katja Jehle ◽  
Katja Schmitz ◽  
Claudia Muhle-Goll ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Unfolded Protein Response ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Unfolded Protein ◽  
Cancer Cell Death ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The unfolded protein response during prostate cancer development

2009 ◽  
Vol 28 (1-2) ◽  
pp. 219-223 ◽  
Author(s):  
Alex Yick-Lun So ◽  
Erwin de la Fuente ◽  
Peter Walter ◽  
Marc Shuman ◽  
Sebastián Bernales
Keyword(s):  
Prostate Cancer ◽  
Unfolded Protein Response ◽  
Cancer Development ◽  
Unfolded Protein ◽  
Prostate Cancer Development ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer

Oncogene ◽  
2019 ◽  
Vol 38 (35) ◽  
pp. 6301-6318 ◽  
Author(s):  
Nora Pällmann ◽  
Marte Livgård ◽  
Martina Tesikova ◽  
Hatice Zeynep Nenseth ◽  
Erman Akkus ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Francesca Amoroso ◽  
Kimberley Glass ◽  
Reema Singh ◽  
Francisco Liberal ◽  
Rebecca E. Steele ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Unfolded Protein Response ◽  
Cancer Cells ◽  
Radiation Response ◽  
Prostate Cancer Cells ◽  
Short Term Treatment ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

AbstractProstate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can lead to cell death. In this study, we sought to enhance the acute activation of the UPR using radiation and ONC201, an UPR activator. Treating PCa cells with ONC201 quickly increased the expression of all the key regulators of the UPR and reduced the oxidative phosphorylation, with cell death occurring 72 h later. We exploited this time lag to sensitize prostate cancer cells to radiation through short-term treatment with ONC201. To understand how priming occurred, we performed RNA-Seq analysis and found that ONC201 suppressed the expression of cell cycle and DNA repair factors. In conclusion, we have shown that ONC201 can prime enhanced radiation response.

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