scholarly journals E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells

Oncotarget ◽  
2016 ◽  
Vol 7 (28) ◽  
pp. 43363-43375 ◽  
Author(s):  
Katie Palen ◽  
James Weber ◽  
Michael B. Dwinell ◽  
Bryon D. Johnson ◽  
Ramani Ramchandran ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Breast Tumor Cells ◽  
Mesenchymal To Epithelial Transition ◽  
Metastatic Breast Tumor ◽  
E Cadherin

scholarly journals Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 442 ◽  
Author(s):  
Yu-Dong Zhou ◽  
Jun Li ◽  
Lin Du ◽  
Fakhri Mahdi ◽  
Thuy Le ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Breast Tumor ◽  
Triple Negative ◽  
Hdac Inhibitors ◽  
Metastatic Breast ◽  
Dependent Manner ◽  
Breast Tumor Cells ◽  
Metastatic Breast Tumor

Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast tumor cells often metastasize to the brain, bone, lung and liver. Massagué and colleagues isolated organotropic subclones and established organ-specific gene signatures associated with lung-, bone-, and brain-specific metastatic triple-negative breast cancer (TNBC) MDA-MB-231 cells. Using these genetically characterized metastatic subclones specific to lung (LM4175), bone (BoM1833), and brain (BrM-2a), we evaluated marine natural products for the ability to differentially suppress metastatic breast cancer cells in a target organ-dependent manner. Psammaplin-based histone deacetylase (HDAC) inhibitors were found to differentially inhibit HDAC activity, induce activation of hypoxia-inducible factor-1 (HIF-1), and disrupt organotropic metastatic TNBC subclone growth. Further, psammaplins distinctly suppressed the outgrowth of BoM1833 tumor spheroids in 3D-culture systems. Similar results were observed with the prototypical HDAC inhibitor trichostatin A (TSA). These organotropic tumor cell-based studies suggest the potential application of HDAC inhibitors that may yield new directions for anti-metastatic breast tumor research and drug discovery.

scholarly journals Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Lubna H Tahtamouni ◽  
Alisa E Shaw ◽  
Maram H Hasan ◽  
Salem R Yasin ◽  
James R Bamburg
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Breast Tumor Cells ◽  
Metastatic Breast Tumor

Bone-derived soluble factors and laminin-511 cooperate to promote migration, invasion and survival of bone-metastatic breast tumor cells

2014 ◽  
Vol 32 (2) ◽  
pp. 63-73 ◽  
Author(s):  
Delphine Denoyer ◽  
Nicole Kusuma ◽  
Allan Burrows ◽  
Xiawei Ling ◽  
Lara Jupp ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Soluble Factors ◽  
Breast Tumor Cells ◽  
Metastatic Breast Tumor

scholarly journals TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells

2011 ◽  
Vol 308 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Gengyun Wen ◽  
Michael A. Partridge ◽  
Bingyan Li ◽  
Mei Hong ◽  
Wupeng Liao ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Metastatic Potential ◽  
Breast Tumor Cells

scholarly journals Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e67278 ◽  
Author(s):  
Parul Gupta ◽  
Chris Adkins ◽  
Paul Lockman ◽  
Sanjay K. Srivastava
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Phenethyl Isothiocyanate ◽  
Breast Tumor Cells ◽  
Metastasis Model
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