scholarly journals HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (25) ◽  
pp. 37966-37978 ◽  
Author(s):  
Anqi Li ◽  
Zebing Liu ◽  
Ming Li ◽  
Shuling Zhou ◽  
Yan Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Therapeutic Target ◽  
Human Breast Cancer ◽  
Prognostic Biomarker ◽  
Human Breast ◽  
Potential Therapeutic Target ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Kai Fang ◽  
Hu Caixia ◽  
Zhang Xiufen ◽  
Guo Zijian ◽  
Lihua Li
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Human Breast ◽  
Free Survival ◽  
Invasion And Migration ◽  
Basal Like Breast Cancer ◽  
And Migration ◽  
Cancer Tissues

Understanding of prognostic factors and therapeutic targets for breast cancer is imperative for guidance of patient care. We studied 1203 tumour samples from the Gene Expression Omnibus (GEO) to evaluate potential genes related to breast cancer. R software was used to analyse differentially expressed long noncoding RNAs (lncRNAs) in the RNA microarray expression profiles GSE45827 and GSE65216 and to identify a series of differentially expressed lncRNAs associated with human breast cancer. Of these lncRNAs, A2M-AS1, a lncRNA that has not been previously reported, was significantly upregulated in human breast cancer tissues compared with adjacent nontumour tissues. Importantly, A2M-AS1 upregulation was significantly associated with ER-negative, HER2-positive, and basal-like breast cancer and with poor recurrence-free survival and metastasis-free survival in breast cancer patients. After validating these results in 96 collected human breast cancer tissues and 64 paired adjacent noncancerous tissues, we further investigated the roles of A2M-AS1 in human ER-negative and basal-like breast cancer cells. The results revealed that A2M-AS1 significantly promotes human breast cancer cell proliferation, invasion, and migration. Additionally, bioinformatics analysis of genes coexpressed with A2M-AS1 in the context of human breast cancer combined with qRT-PCR and Western blot assays revealed that A2M-AS1 exerts regulatory effects on downstream factors in the cell adhesion molecule pathway, including CD2 and SELL. These results imply that A2M-AS1 might be a promising candidate prognostic factor and therapeutic target for breast cancer.

Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer

2012 ◽  
Vol 113 (6) ◽  
pp. 1904-1914 ◽  
Author(s):  
Shuling Wang ◽  
Weidong Li ◽  
Ning Liu ◽  
Fei Zhang ◽  
Han Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Therapeutic Target ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Potential Therapeutic Target

RUNX3 is a prognostic marker and potential therapeutic target in human breast cancer

2013 ◽  
Vol 139 (11) ◽  
pp. 1813-1823 ◽  
Author(s):  
Jin Bai ◽  
Hong-Mei Yong ◽  
Fei-Fei Chen ◽  
Wen-Bo Song ◽  
Chen Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Potential Therapeutic Target

scholarly journals miR-518a-3p Suppresses Triple-Negative Breast Cancer Invasion and Migration Through Regulation of TMEM2

2020 ◽  
Vol 19 ◽  
pp. 153303382097752
Author(s):  
Lin Gan ◽  
Huachao Yang ◽  
Zhifeng Xiong ◽  
Zailiang Yang ◽  
Ting Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Cell Invasion ◽  
Therapeutic Target ◽  
Triple Negative ◽  
Janus Kinase ◽  
Potential Therapeutic Target ◽  
Invasion And Migration ◽  
Over Expression ◽  
And Migration

MicroRNAs (miRNAs) are emerging as critical mediators in tumors, including triple-negative breast cancer (TNBC). The role of miR-518a-3p in TNBC was investigated to identify potential therapeutic target. Data from KM Plotter database ( www.kmplot.com ) showed that high miR-518a-3p expression was significantly associated with overall survival of patients with TNBC ( p = 0.04). The expression of miR-518a-3p was dysregulated in TNBC cells. Functional assays revealed that over-expression of miR-518a-3p inhibited cell invasion and migration of TNBC. Additionally, miR-518a-3p could target TMEM2 (transmembrane protein 2), and decreased protein and mRNA expression of TMEM2 in TNBC cells. Knockdown of TMEM2 suppressed cell invasion and migration through inhibiting phospho (p)-JAK1 (Janus kinase 1) and p-STAT (signal transducer and activator of transcription protein) 1/2. Moreover, over-expression of TMEM2 counteracted the suppressive effect of miR-518a-3p on TNBC invasion and migration through promoting the levels of p-JAK1 and p-STAT1/2. In conclusion, miR-518a-3p negatively regulates the JAK/STAT pathway via targeting TMEM2 and suppresses invasion and migration in TNBC, suggesting that miR-518a-3p may be a potential therapeutic target in TNBC.

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