scholarly journals Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34988-35000 ◽  
Author(s):  
Yves-Paul Vandewynckel ◽  
Céline Coucke ◽  
Debby Laukens ◽  
Lindsey Devisscher ◽  
Annelies Paridaens ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Unfolded Protein Response ◽  
Proteasome Inhibitor ◽  
Next Generation ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4

Autophagy ◽  
2012 ◽  
Vol 8 (12) ◽  
pp. 1873-1874 ◽  
Author(s):  
Yan Zang ◽  
Sufi M. Thomas ◽  
Elena T. Chan ◽  
Christopher J. Kirk ◽  
Maria L. Freilino ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Proteasome Inhibitors ◽  
Next Generation ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Haematologica ◽  
2011 ◽  
Vol 97 (1) ◽  
pp. 64-72 ◽  
Author(s):  
S. C. W. Ling ◽  
E. K. K. Lau ◽  
A. Al-Shabeeb ◽  
A. Nikolic ◽  
A. Catalano ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Proteasome Inhibitor ◽  
Response Regulator ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

2014 ◽  
Vol 9 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Yves-Paul Vandewynckel ◽  
Debby Laukens ◽  
Eliene Bogaerts ◽  
Annelies Paridaens ◽  
Anja Van den Bussche ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cell ◽  
Unfolded Protein Response ◽  
Cell Adaptation ◽  
Unfolded Protein ◽  
Proteotoxic Stress ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The Unfolded Protein Response Is Associated with Cancer Proliferation and Worse Survival in Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4443
Author(s):  
Ankit Patel ◽  
Masanori Oshi ◽  
Li Yan ◽  
Ryusei Matsuyama ◽  
Itaru Endo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Unfolded Protein Response ◽  
Cancer Progression ◽  
Cancer Biology ◽  
Immune Cell ◽  
Histological Grade ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Hepatocellular carcinoma is a leading cause of cancer death worldwide. The unfolded protein response (UPR) has been revealed to confer tumorigenic capacity in cancer cells. We hypothesized that a quantifiable score representative of the UPR could be used as a biomarker for cancer progression in HCC. In this study, a total of 655 HCC patients from 4 independent HCC cohorts were studied to examine the relationships between enhancement of the UPR and cancer biology and patient survival in HCC utilizing an UPR score. The UPR correlated with carcinogenic sequence and progression of HCC consistently in two cohorts. Enhanced UPR was associated with the clinical parameters of HCC progression, such as cancer stage and multiple parameters of cell proliferation, including histological grade, mKI67 gene expression, and enrichment of cell proliferation-related gene sets. The UPR was significantly associated with increased mutational load, but not with immune cell infiltration or angiogeneis across independent cohorts. The UPR was consistently associated with worse survival across independent cohorts of HCC. In conclusion, the UPR score may be useful as a biomarker to predict prognosis and to better understand HCC.

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