scholarly journals Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density

Oncotarget ◽  
2016 ◽  
Vol 7 (21) ◽  
pp. 31429-31439 ◽  
Author(s):  
Jinsong Wei ◽  
Ming Li ◽  
Feng Gao ◽  
Rong Zeng ◽  
Guiyou Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Association Study ◽  
Bone Mineral ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Spine Bone Mineral Density ◽  
Genome Wide Association ◽  
Mineral Density ◽  
Genome Wide

scholarly journals Genome-wide association study of bone mineral density trait among three pig breeds

animal ◽  
2020 ◽  
Vol 14 (12) ◽  
pp. 2443-2451
Author(s):  
B. Jiang ◽  
M. Wang ◽  
Z. Tang ◽  
X. Du ◽  
S. Feng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Association Study ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Mineral Density ◽  
Pig Breeds ◽  
Genome Wide

scholarly journals Identification of Potential Novel Pleiotropic Susceptibility Variants Common To Lumbar Spine Bone Mineral Density And Birth Weight

2021 ◽  
Author(s):  
Yu-Qian Song ◽  
Shi-Di Hu ◽  
Xu Lin ◽  
Xiang-He Meng ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Birth Weight ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Epidemiological Studies ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Genome Wide ◽  
Genetic Mechanisms

Abstract An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes (NTAN1, PDXDC1, CACNA1G, JAG1, FAT1P1, CCDC170, ESR1), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1, supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development.

scholarly journals Genome-wide association study of lncRNA polymorphisms with bone mineral density

2018 ◽  
Vol 82 (5) ◽  
pp. 244-253 ◽  
Author(s):  
Qin Zeng ◽  
Ke-Hao Wu ◽  
Kun Liu ◽  
Yuan Hu ◽  
Xiang-Ding Chen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Association Study ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Mineral Density ◽  
Genome Wide

scholarly journals Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density

BMC Genomics ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Benjamin H. Mullin ◽  
John P. Walsh ◽  
Hou-Feng Zheng ◽  
Suzanne J. Brown ◽  
Gabriela L. Surdulescu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Association Study ◽  
Bone Mineral ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Mineral Density ◽  
Genome Wide ◽  
Family Based
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