A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor

Carina Lotz-Jenne; Urs Lüthi; Sabine Ackerknecht; François Lehembre; Tobias Fink; Manuel Stritt; Matthias Wirth; Simona Pavan; Ruben Bill; Urs Regenass; Gerhard Christofori; Nathalie Meyer-Schaller

doi:10.18632/oncotarget.8418

A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor

Oncotarget ◽

10.18632/oncotarget.8418 ◽

2016 ◽

Vol 7 (18) ◽

pp. 25983-26002 ◽

Cited By ~ 12

Author(s):

Carina Lotz-Jenne ◽

Urs Lüthi ◽

Sabine Ackerknecht ◽

François Lehembre ◽

Tobias Fink ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Tgfβ Receptor ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.04.019 ◽

2008 ◽

Vol 16 (10) ◽

pp. 5514-5528 ◽

Cited By ~ 22

Author(s):

Aleem Gangjee ◽

Ojas A. Namjoshi ◽

Jianming Yu ◽

Michael A. Ihnat ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Antiangiogenic Agents ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.01.029 ◽

2012 ◽

Vol 20 (7) ◽

pp. 2444-2454 ◽

Cited By ~ 11

Author(s):

Aleem Gangjee ◽

Nilesh Zaware ◽

Sudhir Raghavan ◽

Jie Yang ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

In Vivo Evaluation ◽

Design Synthesis ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

RETROSPECTIVE REAL-WORLD OUTCOMES FOR ALK-REARRANGED LUNG CANCER PATIENTS RECEIVING ALK-RECEPTOR TYROSINE KINASE INHIBITORS

JTO Clinical and Research Reports ◽

10.1016/j.jtocrr.2021.100157 ◽

2021 ◽

pp. 100157

Author(s):

Amanda J.W. Gibson ◽

Adrian Box ◽

Michelle L. Dean ◽

Anifat A. Elegbede ◽

Desiree Hao ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Patients ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Real World ◽

Kinase Inhibitors ◽

Lung Cancer Patients ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review)

Pharmaceutical Chemistry Journal ◽

10.1007/s11094-021-02419-8 ◽

2021 ◽

Author(s):

M. T. Kozinova ◽

G. A. Abalakov ◽

D. V. Sharipova ◽

N. L. Shimanovsky

Keyword(s):

Tyrosine Kinase ◽

Gastrointestinal Stromal Tumor ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Genetic Basis ◽

Kinase Inhibitors ◽

Molecular Genetic ◽

Personalized Therapy ◽

Molecular Genetic Basis ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Natural Product Derived Receptor Tyrosine Kinase Inhibitors: Identification of IGF1R, Tie-2, and VEGFR-3 Inhibitors

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v ◽

2002 ◽

Vol 41 (7) ◽

pp. 1174-1178 ◽

Cited By ~ 52

Author(s):

Petra Stahl ◽

Lars Kissau ◽

Ralph Mazitschek ◽

Athanassios Giannis ◽

Herbert Waldmann

Keyword(s):

Tyrosine Kinase ◽

Natural Product ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.08.025 ◽

2010 ◽

Vol 20 (20) ◽

pp. 6129-6132 ◽

Cited By ~ 13

Author(s):

Chih-Hung Chen ◽

On Lee ◽

Chung-Niang Yao ◽

Meng-Yun Chuang ◽

Yow-Lone Chang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy

Veterinary and Comparative Oncology ◽

10.1111/j.1476-5829.2012.00342.x ◽

2012 ◽

Vol 10 (3) ◽

pp. 163-173 ◽

Cited By ~ 15

Author(s):

S. Bavcar ◽

D. J. Argyle

Keyword(s):

Cancer Therapy ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Targeted Drugs ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.02.025 ◽

2006 ◽

Vol 16 (10) ◽

pp. 2672-2676 ◽

Cited By ~ 20

Author(s):

Laurent F.A. Hennequin ◽

Peter Ballard ◽

F. Tom Boyle ◽

Bénédicte Delouvrié ◽

Rebecca P.A. Ellston ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Egf Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm980398y ◽

1998 ◽

Vol 41 (22) ◽

pp. 4365-4377 ◽

Cited By ~ 55

Author(s):

Diane H. Boschelli ◽

Zhipei Wu ◽

Sylvester R. Klutchko ◽

H. D. Hollis Showalter ◽

James M. Hamby ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Inhibitory Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Kinase Inhibitory Activity ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2017.04.001 ◽

2017 ◽

Vol 72 ◽

pp. 116-122 ◽

Cited By ~ 9

Author(s):

Weijie Gu ◽

Yuxuan Dai ◽

Hao Qiang ◽

Wei Shi ◽

Chen Liao ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Pyridine Derivatives ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text