scholarly journals shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (20) ◽  
pp. 28989-28997 ◽  
Author(s):  
Jianfa Li ◽  
Chengle Zhuang ◽  
Yuchen Liu ◽  
Mingwei Chen ◽  
Qing Zhou ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Non Coding Rna ◽  
Bladder Cancer Cells ◽  
Long Non Coding Rna ◽  
Tetracycline Inducible System

scholarly journals The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

2017 ◽  
Vol 43 (1) ◽  
pp. 405-418 ◽  
Author(s):  
Yaoyao Xiong ◽  
Long Wang ◽  
Yuan Li ◽  
Minfeng Chen ◽  
Wei He ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Cancer Growth ◽  
Invasion And Migration ◽  
Non Coding Rna ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Backgrounds/Aims: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. Results: XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells’ proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3’UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. Conclusion: These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation.

scholarly journals Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Yonghao Zhan ◽  
Zhicong Chen ◽  
Shiming He ◽  
Yanqing Gong ◽  
Anbang He ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Non Coding Rna ◽  
Bladder Cancer Cells ◽  
Long Non Coding Rna

scholarly journals Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells

Oncotarget ◽  
2015 ◽  
Vol 6 (38) ◽  
pp. 41194-41203 ◽  
Author(s):  
Chengle Zhuang ◽  
Jianfa Li ◽  
Yuchen Liu ◽  
Mingwei Chen ◽  
Jiancheng Yuan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Non Coding Rna ◽  
Bladder Cancer Cells ◽  
Long Non Coding Rna
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