scholarly journals TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5

Oncotarget ◽  
2013 ◽  
Vol 4 (2) ◽  
pp. 206-217 ◽  
Author(s):  
Jun-Jie Chen ◽  
Constantinos M. Mikelis ◽  
Yaqin Zhang ◽  
J. Silvio Gutkind ◽  
Baolin Zhang
Keyword(s):  
Cell Surface ◽  
Death Receptor ◽  
Squamous Carcinoma ◽  
Surface Expression ◽  
Carcinoma Cells ◽  
Cell Surface Expression ◽  
Death Receptor 5 ◽  
Oncogenic Ras ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

scholarly journals Hypoxia Enhances Fusion of Oral Squamous Carcinoma Cells and Epithelial Cells Partly via the Epithelial–Mesenchymal Transition of Epithelial Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Chun-ming Huang ◽  
Ting-lin Yan ◽  
Zhi Xu ◽  
Meng Wang ◽  
Xiao-cheng Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Epithelial Cells ◽  
Cell Surface ◽  
Cell Fusion ◽  
Squamous Carcinoma ◽  
Fusion Rate ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

Increasing evidence and indications showed that cell fusion is crucial in tumor development and metastasis, and hypoxia, a closely linked factor to tumor microenvironment, which can lead to EMT, induces angiogenesis and metastasis in tumor growth. However, the relationship between hypoxia and fusion has not been reported yet. EMT will change some proteins in the epithelial cell surface and the changes of proteins in cell surface may increase cell fusion. This study found that hypoxia promotes the spontaneous cell fusion between Oral Squamous Carcinoma Cells (OSCCs) and Human Immortalized Oral Epithelial Cells (HIOECs). At the same time, Hypoxia can lead to EMT, and hypoxia-pretreated HIOECs increased fusion rate with OSCC, while the fusion rate was significantly reduced by DAPT, a kind of EMT blocker. Therefore, epithelial cells can increase spontaneously cell fusion with OSCC by EMT. Our study may provide a new insight to link among tumor microenvironment, cell fusion, and cancer.

B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis

Immunobiology ◽  
2011 ◽  
Vol 216 (12) ◽  
pp. 1302-1310 ◽  
Author(s):  
Sabine Groeger ◽  
Eugen Domann ◽  
Jose R. Gonzales ◽  
Trinad Chakraborty ◽  
Joerg Meyle
Keyword(s):  
Porphyromonas Gingivalis ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

scholarly journals The Migration and Invasion of Oral Squamous Carcinoma Cells: Matrix, Growth Factor and Signalling Involvement

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2633
Author(s):  
Ian R. Ellis
Keyword(s):  
Growth Factor ◽  
Cancer Cells ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

The link between the migration of cancer cells and the spread of cancers has been established for many years [...]

scholarly journals Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Wen-Hung Wang ◽  
Kuo-Yu Hsuan ◽  
Ling-Ya Chu ◽  
Chia-Ying Lee ◽  
Yu-Chang Tyan ◽  
...  
Keyword(s):  
Salvia Miltiorrhiza ◽  
Squamous Carcinoma ◽  
Mitochondrial Pathway ◽  
Carcinoma Cells ◽  
Tumor Xenograft ◽  
Alcohol Extract ◽  
Squamous Carcinoma Cells ◽  
Anticancer Effects ◽  
Oral Squamous Carcinoma

Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100 mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.

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