scholarly journals β-casein nanovehicles for oral delivery of chemotherapeutic drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 23322-23334 ◽  
Author(s):  
Maya Bar-Zeev ◽  
Yehuda G. Assaraf ◽  
Yoav D. Livney
Keyword(s):  
Gastric Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Oral Delivery ◽  
Drug Combinations ◽  
Human Gastric Cancer ◽  
Chemotherapeutic Drug ◽  
Gastric Cancer Cells ◽  
P Glycoprotein

Glucosamine Reverses P-Glycoprotein-Mediated Multidrug Resistance in the Daunorubicin-Resistant Human Gastric Cancer Cells

2019 ◽  
Vol 72 (3) ◽  
pp. 522-527
Author(s):  
Fatemeh Valinezhad Sani ◽  
Fatemeh Mosaffa ◽  
Khadijeh Jamialahmadi ◽  
Abbasali Palizban
Keyword(s):  
Gastric Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
P Glycoprotein

DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway

2020 ◽  
Vol 52 (11) ◽  
pp. 1202-1214
Author(s):  
Lejia Qiu ◽  
Zhaoxia Ma ◽  
Xiaoran Li ◽  
Yizhang Deng ◽  
Guangling Duan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Glycoprotein P ◽  
Nrf2 Pathway ◽  
P Glycoprotein ◽  
New Findings ◽  
Nrf2 Signaling Pathway ◽  
Common Malignancy

Abstract Gastric cancer is a common malignancy worldwide. The occurrence of multidrug resistance (MDR) is the major obstacle for effective gastric cancer chemotherapy. In this study, the in-depth molecular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated. The results showed that DJ-1 expression level was higher in MDR variant SGC7901/VCR cells than that in its parental SGC7901 cells. Moreover, DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells, while DJ-1 knockdown in SGC7901/VCR cells induced re-sensitization to adriamycin, vincristine, cisplatin, and 5-fluorouracil. These results suggested that DJ-1 mediated the development of MDR in SGC7901 gastric cancer cells. Importantly, further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells. Meanwhile, we found that PI3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN, consequently resulting in Nrf2 phosphorylation and activation, and thereby inducing Nrf2-dependent P-glycoprotein (P-gp) and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells. Overall, these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells. The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells, prompting its further investigation as a molecular target to overcome MDR.

scholarly journals Special AT-rich sequence binding protein 1 regulates the multidrug resistance and invasion of human gastric cancer cells

2012 ◽  
Vol 4 (1) ◽  
pp. 156-162 ◽  
Author(s):  
FUQIANG SUN ◽  
XIAOMING LU ◽  
HANG LI ◽  
ZHAO PENG ◽  
KE WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Binding Protein ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

2008 ◽  
Vol 123 (2) ◽  
pp. 372-379 ◽  
Author(s):  
Lin Xia ◽  
Dexin Zhang ◽  
Rui Du ◽  
Yanglin Pan ◽  
Lina Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document