scholarly journals Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 22245-22256 ◽  
Author(s):  
Erik Hedrick ◽  
Yating Cheng ◽  
Un-Ho Jin ◽  
Kyounghyun Kim ◽  
Stephen Safe
Keyword(s):  
Transcription Factors ◽  
Cancer Cells ◽  
Oncogene Addiction ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

2011 ◽  
Vol 63 (7) ◽  
pp. 1133-1142 ◽  
Author(s):  
Satya S. Pathi ◽  
Ping Lei ◽  
Sandeep Sreevalsan ◽  
Gayathri Chadalapaka ◽  
Indira Jutooru ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Ascorbic Acid ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

2010 ◽  
Vol 316 (13) ◽  
pp. 2174-2188 ◽  
Author(s):  
Indira Jutooru ◽  
Gayathri Chadalapaka ◽  
Sandeep Sreevalsan ◽  
Ping Lei ◽  
Rola Barhoumi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Arsenic Trioxide ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48208 ◽  
Author(s):  
Satya Pathi ◽  
Indira Jutooru ◽  
Gayathri Chadalapaka ◽  
Vijayalekshmi Nair ◽  
Syng-Ook Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies

2008 ◽  
Vol 42 (1) ◽  
pp. 19-33 ◽  
Author(s):  
Fei Wu ◽  
Ivan Ivanov ◽  
Rui Xu ◽  
Stephen Safe
Keyword(s):  
Transcription Factors ◽  
Rna Interference ◽  
Estrogen Receptor Α ◽  
Independent Analysis ◽  
17Β Estradiol ◽  
Specificity Protein ◽  
Interference Studies ◽  
Sp Transcription Factors ◽  
Mcf 7

17β-Estradiol (E2) binds estrogen receptor α (ESR1) in MCF-7 cells and increases cell proliferation and survival through induction or repression of multiple genes. ESR1 interactions with DNA-bound specificity protein (SP) transcription factors is a nonclassical genomic estrogenic pathway and the role of SP transcription factors in mediating hormone-dependent activation or repression of genes in MCF-7 cells was investigated by microarrays and RNA interference. MCF-7 cells were transfected with a nonspecific oligonucleotide or a cocktail of small inhibitory RNAs (iSP), which knockdown SP1, SP3, and SP4 proteins, and treated with dimethylsulfoxide or 10 nM E2 for 6 h. E2 induced 62 and repressed 134 genes and the induction or repression was reversed in ∼62% of the genes in cells transfected with iSP (ESR1/SP dependent), whereas hormonal activation or repression of the remaining genes was unaffected by iSP (SP independent). Analysis of the ESR1/SP-dependent and SP-independent genes showed minimal overlap with respect to the GO terms (functional processes) in genes induced or repressed, suggesting that the different genomic pathways may contribute independently to the hormone-induced phenotype in MCF-7 cells.

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