scholarly journals The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 13106-13121 ◽  
Author(s):  
Jonathan H. Shepherd ◽  
Ivan P. Uray ◽  
Abhijit Mazumdar ◽  
Anna Tsimelzon ◽  
Michelle Savage ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Transcription Factor ◽  
Cancer Growth ◽  
Basal Like Breast Cancer ◽  
Breast Cancer Growth

scholarly journals 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

2007 ◽  
Vol 9 (4) ◽  
Author(s):  
Yunpeng Su ◽  
Kathryn Vanderlaag ◽  
Courtney Ireland ◽  
Janelle Ortiz ◽  
Henry Grage ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nude Mice ◽  
Cancer Growth ◽  
Athymic Nude Mice ◽  
Basal Like Breast Cancer ◽  
Breast Cancer Growth

318 Control of Breast Cancer Growth and Initiation by the Stem Cell-associated Transcription Factor TCF3

2012 ◽  
Vol 48 ◽  
pp. S78
Author(s):  
I. Ben-Porath ◽  
M. Slyper ◽  
A. Shahar ◽  
A. Bar-Ziv ◽  
R.Z. Granit ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Stem Cell ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

Oncogene ◽  
2002 ◽  
Vol 21 (50) ◽  
pp. 7680-7689 ◽  
Author(s):  
Yongmin Liu ◽  
John Ludes-Meyers ◽  
Yun Zhang ◽  
Debbie Munoz-Medellin ◽  
Hee-Tae Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Transcription Factor ◽  
Cancer Growth ◽  
Signal Transduction Pathways ◽  
Multiple Signal ◽  
Breast Cancer Growth

Control of Breast Cancer Growth and Initiation by the Stem Cell–Associated Transcription Factor TCF3

2012 ◽  
Vol 72 (21) ◽  
pp. 5613-5624 ◽  
Author(s):  
Michal Slyper ◽  
Amit Shahar ◽  
Anat Bar-Ziv ◽  
Roy Z. Granit ◽  
Tamar Hamburger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Stem Cell ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Periostin Short Fragment with Exon 17 via Aberrant Alternative Splicing Is Required for Breast Cancer Growth and Metastasis

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 892
Author(s):  
Yuka Ikeda-Iwabu ◽  
Yoshiaki Taniyama ◽  
Naruto Katsuragi ◽  
Fumihiro Sanada ◽  
Nobutaka Koibuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Matrix Protein ◽  
Interaction Analysis ◽  
Terminal Region ◽  
Cancer Growth ◽  
Collagen Gene ◽  
Short Fragment ◽  
Breast Cancer Growth

Background: Periostin (POSTN) is a 93 kDa matrix protein that helps to regulate collagen gene expression in the extracellular matrix. POSTN overexpression is a prognostic factor in malignant cancers; however, some researchers have observed it in the stroma, whereas others have reported it on tumors. Objective: This study aimed to investigate the function of POSTN on tumors. Methods and Results: We found that POSTN in cancer cells can be detected by using an antibody against the POSTN C-terminal region exon 17 (Ex17 antibody), but not with an antibody against the POSTN N-terminal region exon 12 (Ex12 antibody) in patients with breast cancer. In a fraction secreted from fibroblasts, LC–MS/MS analysis revealed a short fragment of POSTN of approximately 40 kDa with exon 17. In addition, molecular interaction analysis showed that POSTN with exon 17, but not POSTN without exon 17, bound specifically to wnt3a, and the Ex17 antibody inhibited the binding. Conclusion: A short fragment of POSTN with exon 17, which originates in the fibroblasts, is transported to cancer cells, whereas POSTN fragments without exon 17 are retained in the stroma. The Ex17 antibody inhibits the binding between POSTN exon 17 and wnt3a.

Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition

2014 ◽  
Vol 90 (3) ◽  
pp. 226-234 ◽  
Author(s):  
Cristina Kalogris ◽  
Chiara Garulli ◽  
Lucia Pietrella ◽  
Valentina Gambini ◽  
Stefania Pucciarelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dihydrofolate Reductase ◽  
Cancer Growth ◽  
Basal Like Breast Cancer ◽  
Breast Cancer Growth
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